Treatment with oral vitamin D alone, topical minoxidil, or combination of both in patients with female pattern hair loss: A comparative clinical and dermoscopic study

Hassan, Arwa M.; Sadoma, Manar E. T.; Elbatsh, Manal Mohamed Ali; Ibrahim, Zainab A.

doi:10.1111/jocd.14743

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…Data is scarce regarding the efficacy of vitamin D supplementation or topical solution for patients with vitamin D deficiency and concomitant alopecia. However, animal model studies have found benefit with vitamin D supplementation [69], and oral vitamin D supplementation with minoxidil was found to be significantly more effective than minoxidil alone in the treatment of FPAnA [70]. Yet, oral vitamin D monotherapy did not result in significant improvement.…”

Section: Vitamin Dmentioning

confidence: 98%

Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

Natarelli

Gahoonia

Sivamani

2023

JCM

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The hair cycle is composed of four primary phases: anagen, catagen, telogen, and exogen. Anagen is a highly mitotic phase characterized by the production of a hair shaft from the hair follicle, whereas catagen and telogen describe regression and the resting phase of the follicle, respectively, ultimately resulting in hair shedding. While 9% of hair follicles reside in telogen at any time, a variety of factors promote anagen to telogen transition, including inflammation, hormones, stress, nutritional deficiency, poor sleep quality, and cellular division inhibiting medication. Conversely, increased blood flow, direct stimulation of the hair follicle, and growth factors promote telogen to anagen transition and subsequent hair growth. This review seeks to comprehensively describe the hair cycle, anagen and telogen balance, factors that promote anagen to telogen transition and vice versa, and the clinical utility of a variety of lab testing and evaluations. Ultimately, a variety of factors impact the hair cycle, necessitating a holistic approach to hair loss.

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Section: Vitamin Dmentioning

confidence: 98%

Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

Natarelli

Gahoonia

Sivamani

2023

JCM

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“…Research data showed a link between a poor serum vitamin D levels and telogen effluvium (28). Recent studies report that for female pattern baldness, the use of oral vitamin D together with topical minoxidil has better results than applying minoxidil alone (29). Biotin Although it has become popular among consumers, biotin has not been shown to be effective in healthy individuals for nail and hair growth.…”

Section: Supplementation and Treatment Strategies Multivitaminsmentioning

confidence: 99%

Hair loss following COVID-19 infection - the state of current knowledge and treatment approaches.

RUDZIŃSKI

KUSAK

Brzuszkiewicz

et al. 2022

J Educ Health Sport

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Introduction: Telogen effluvium is a non-scarring hair loss that can occur after COVID-19 infection. It usually occurs after about 3 months, causes diffused hair loss and lasts up to 6 months. The purpose of this narrative review is to collect and summarize the effects of potential methods to promote hair regrowth in patients after COVID-19 infection. Material and method: The article reviews available in PubMed and ResearchGate databases, studies on telogen effluvium and SARS-CoV-2. Due to the limited literature, articles on telogenetic hair loss progressing independently of COVID-19 were also included in the review. Results: Hair loss after COVID-19 infection occurs in almost 30% of patients. This is likely related to pro-inflammatory cytokines released during infection and the pro-thrombotic effect of the virus. Telogen effluvium is the most common type of alopecia occurring after COIVD-19 infection - about 86% of all cases. It affects women more often than men. It seems that its severity may correlate with the severity of the infection. Other than female gender and a history of chronic disease, it is unlikely to find any other contributing factors. Effective treatments seem to include the use of oral supplements such as vitamin D, polyunsaturated fatty acids and zinc. In addition, topical application of minoxidil and high-platelet plasma treatments have shown good outcomes. Conclusions: Given the fairly common occurrence of hair loss after COVID-19 infection, it seems reasonable to seek the most effective strategies for its treatment. At present, it appears that the best results are obtained by combining different treatment approaches.

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Serum 25 hydroxyvitamin D in non‐scarring alopecia: A systematic review and meta‐analysis

Chen,

Dong,

Wang

et al. 2023

J of Cosmetic Dermatology

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IntroductionNon‐scarring alopecia mainly includes androgenetic alopecia (AGA), female pattern hair loss (FPHL), alopecia areata (AA), telogen effluvium (TE), anagen effluvium (AE) and so on. Many studies had investigated the serum 25‐hydroxyvitamin D level and vitamin D deficiency of patients with these diseases, but opinions varied, and no conclusion was reached.MethodsRelevant articles were retrieved through PubMed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and other databases. Serum 25‐hydroxyvitamin D [25(OH) D] levels and vitamin D deficiency were used as our primary outcome. The odds ratio (OR) and the standardized mean difference (SMD) with 95% confidence interval were both examined for vitamin D deficiency and levels.ResultsOur meta‐analysis had included a total of 3374 non‐scarring alopecia patients and 7296 healthy controls from 23 studies through the inclusion criteria and exclusion criteria. We found non‐scarring alopecia had decreased serum 25(OH)D level (WMD −7.29; 95% CI −9.21, −5.38) and increased vitamin D deficiency incidence (OR 3.11 95% CI 2.29, 4.22), compared with healthy controls. This meta‐analysis chose to conduct random‐effect model and subgroup analysis, because of the high heterogeneity (serum 25(OH)D level: I2 = 95%, vitamin D deficiency: I2 = 0%).ConclusionPatients with non‐scarring alopecia (including AA, FPHL, AGA and TE) have insufficient serum level of 25(OH)D and increased incidence of vitamin D deficiency. Vitamin D supplementation and monitoring for vitamin D deficiency may be helpful in treating non‐scarring alopecia.

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Treatment with oral vitamin D alone, topical minoxidil, or combination of both in patients with female pattern hair loss: A comparative clinical and dermoscopic study

Cited by 5 publications

References 23 publications

Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

Hair loss following COVID-19 infection - the state of current knowledge and treatment approaches.

Serum 25 hydroxyvitamin D in non‐scarring alopecia: A systematic review and meta‐analysis

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