A randomized clinical study for comparative evaluation of Aloe Vera and 0.2% chlorhexidine gluconate mouthwash efficacy on de-novo plaque formation

Abstract

Objective:To comparatively assess the antiplaque efficacy of Aloe vera mouthwash and 0.2% chlorhexidine gluconate mouthwash on de novo plaque formation.Materials and Methods:This was a randomized, single blind, parallel, controlled clinical study with 90 healthy participants, with mean age of 27.19 ± 12.08 years. After thorough oral prophylaxis, participants were instructed to discontinue mechanical plaque control. Participants were divided randomly into three groups; pure Aloe vera mouthwash was dispensed to the test group; control group received 0.2% chlorhexidine gluconate mouthwash; in Placebo group, flavored distilled water was used as oral rinse twice daily. Effect on 4-day de novo plaque formation was assessed by comparing pre-rinsing Quigley Hein Modified Plaque Scores were analyzed statistically using analysis of variance and Student's t-test.Results:Post-rinsing control group showed the least plaque score which was comparable to the test group. Both the control group and test group showed significant difference with the placebo group.Conclusions:Herbal mouthwash containing Aloe vera mouthwash has comparable antiplaque efficacy as the gold standard 0.2% chlorhexidine gluconate with fewer side effects and can be considered as an alternative.

Antifungal Effects of Aloe Vera Irrigant on Candida Albicans Biofilm

“…Further, the hyphae were only found in C. albicans biofilm. In this study, biofilm was formed in a 96-well plate to allow its growth on standardized surfaces and incubated for 24 h because it has been estimated that C. albicans biofilms are formed within 24 h, thus providing a more accurate assessment of the effectiveness of antifungal agents [17]. It was important to standardize the age of biofilms when comparing the effectiveness of antifungal agents [15].…”

Effect of Aloe Vera mouthwash on moderate gingivitis: Clinical and microbiological study

“…Participants with probing pocket depth > 3 mm, patients receiving periodontal therapy three months prior to the study, pregnant or lactating women, smokers and patients with crowned teeth were excluded from the study. 8 The practical part was carried out during the period between 15 th of February and 1 st of June 2018. Study Design.…”

“…Ingestion of liquids or solids was permitted only after 30 minutes of rinsing. 8 Dark glass bottles of identical appearance with a volume of 300 ml of solution were dispensed to each participant, a measure of 10 ml scale to ensure dosage accuracy was dispensed for the patients, a low ingredients tooth paste was provided for the patients during the study period in order to minimize its effects on the study results, identical soft tooth brushes were provided for the patients.…”

“…7 The bactericidal activity of Aloe Vera against plaque bacteria is attributed to a number of pharmacologically active compounds including anthraquinones, aloin, aloe-emodin, aloetic acid, anthracine, aloe mannan, aloeride, antranol, acemannan, chrysophanic acid, resistanol, dihydroxyanthraquinones and saponins. 8,9 Aloin and aloe-emodin have polyphenolic structures, which can inhibit protein synthesis by bacterial cells, thus explaining their antimicrobial activity. This characteristic may also explain the anti-inflammatory activity of Aloe Vera.…”

“…This characteristic may also explain the anti-inflammatory activity of Aloe Vera. 8,9 Saponins, contains glycoside, a soapy substance that have both cleansing and antiseptic properties. It is noteworthy that some compounds like anthraquinones and saponins present in Aloe Vera gel have a direct antibacterial activity while some other components, such as acemannan, have been considered to show indirect bactericidal activity through stimulation of phagocytosis.…”