A randomized clinical study to assess ingestion of dentifrice by children

Strittholt, C.A.; McMillan, Donna A.; He, Tao; Baker, Robert A.; Barker, Matthew L

doi:10.1016/j.yrtph.2015.12.008

Cited by 12 publications

(8 citation statements)

References 10 publications

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“…In 2018, Bernard and colleagues produced a probabilistic evaluation of the exposure of oral cosmetics using recent data from French consumption across different age groups [310]. Finally, Strittholt and colleagues, in an RCT study, looked for whether there was a difference in the amount of toothpaste ingested by children using pea-size dosing instructions [311].…”

Section: Complementary Contentmentioning

confidence: 99%

Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation

et al. 2020

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Many investigations have pointed out widespread use of medical nanosystems in various domains of dentistry such as prevention, prognosis, care, tissue regeneration, and restoration. The progress of oral medicine nanosystems for individual prophylaxis is significant for ensuring bacterial symbiosis and high-quality oral health. Nanomaterials in oral cosmetics are used in toothpaste and other mouthwash to improve oral healthcare performance. These processes cover nanoparticles and nanoparticle-based materials, especially domains of application related to biofilm management in cariology and periodontology. Likewise, nanoparticles have been integrated in diverse cosmetic produces for the care of enamel remineralization and dental hypersensitivity. This review summarizes the indications and applications of several widely employed nanoparticles in oral cosmetics, and describes the potential clinical implementation of nanoparticles as anti-microbial, anti-inflammatory, and remineralizing agents in the prevention of dental caries, hypersensitivity, and periodontitis.

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Section: Complementary Contentmentioning

confidence: 99%

Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation

et al. 2020

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“…sodium monofluorophosphate (Na 2 PO 3 F), or stannous fluoride (SnF 2 ) are well-known for their caries preventing effect and consequently they are frequently used in many toothpaste formulations 6,14,[16][17][18] . However, it is known that infants and toddlers swallow a substantial proportion of the applied toothpaste during toothbrushing [19][20][21][22][23][24] , which can increase the systemic uptake of fluorides beyond a threshold associated with the occurrence of dental fluorosis and other unwanted side effects 19,25 . Therefore, in many countries toothpastes for children contain a reduced amount of fluorides compared to toothpastes for adults 17 .…”

mentioning

confidence: 99%

Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trial

Paszyńska

Pawińska

Gawriołek

et al. 2021

Sci Rep

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The aim of this trial was to determine whether a toothpaste with microcrystalline hydroxyapatite is not inferior to a fluoride toothpaste in prevention of caries in children. This double-blinded randomized control trial compared two toothpastes regarding the occurrence of caries lesions using International Caries Detection and Assessment System (ICDAS) ≥ code 1 on the primary dentition within 336 days. The test group used a fluoride-free hydroxyapatite toothpaste three times daily while control group used a toothpaste with fluoride. 207 children were included in the intention-to-treat analysis; 177 of them finished the study per protocol. An increase in caries ICDAS ≥ code 1 per tooth was observed in 72.7% of the hydroxyapatite-group (n = 88), compared with 74.2% of the fluoride-group (n = 89). The exact one-sided upper 95% confidence limit for the difference in proportion of participants with ICDAS increase ≥ 1 (-1.4%) was 9.8%, which is below the non-inferiority margin of 20% demonstrating non-inferiority of hydroxyapatite compared to the fluoride control toothpaste. This RCT showed for the first time, that in children, the impact of the daily use of a toothpaste with microcrystalline hydroxyapatite on enamel caries progression in the primary dentition is not inferior to a fluoride control toothpaste (Clinical Trials NCT03553966).

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“…Dietary fluoride supplements were a minor source of ingested fluoride, as supplement use from 6 to 17 years of age was minimal. In a previous study of the Iowa Fluoride Study cohort, Hamasha et al [25,26] reported that, at age 92 months, only 3.5% of the study participants were using dietary fluoride supplements. Hamasha et al [25,26] also found that, among participants who used dietary fluoride supplements, the estimated daily average fluoride ingested from supplements increased from 0.06 (birth‐12 months) to 0.07 mg (12–60 months) to 0.18 mg (60–96 months).…”

Section: Discussionmentioning

confidence: 99%

Patterns of fluoride intake from 6 to 17 years of age: The Iowa Fluoride Study

Bhagavatula

Comnick

Warren

et al. 2022

J Public Health Dent

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Objectives: This article reports on estimated daily fluoride intake from water, other beverages and selected foods, dentifrice, and dietary fluoride supplements by both individual sources, and all sources combined, among 787 children participating in the Iowa Fluoride Study (IFS) from 6 to 17 years of age. Methods: Total daily fluoride intake (mg F) and fluoride intake per kilogram bodyweight (mg F/kg bw) were estimated using responses to questionnaires sent every 3-6 months. Dietary assessments included frequencies and amounts of beverage intake for the previous week from water, milk, ready-to-drink beverages, beverages made by adding water to concentrate or powder, and selected foods with substantial water content. Descriptive statistics and bivariate and multivariable analyses with linear mixed models were used to assess associations with each of mg F and mg F/kg bw. Results: Mean combined dietary fluoride (mg F) from all sources examined in the study increased slightly with age, whereas the fluoride intake per kg bw decreased with age. Age, sex, and socioeconomic status were significantly associated with fluoride intake (mg F and mg F/kg bw). Each year increase in age was associated with a 0.02-mg increase in fluoride consumption, on average, after adjusting for the effects of covariates. Conclusions: Daily mean fluoride intakes from single and combined sources were relatively stable, while the intake of fluoride per kg bw decreased from 6 to 17 years of age. Fluoridated water was the major source of ingested fluoride, contributing over 50% of total daily intake at all ages.

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A randomized clinical study to assess ingestion of dentifrice by children

Cited by 12 publications

References 10 publications

Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation

Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation

Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trial

Patterns of fluoride intake from 6 to 17 years of age: The Iowa Fluoride Study

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