A Randomized Clinical Trial of Cryotherapy, Laser Vaporization, and Loop Electrosurgical Excision for Treatment of Squamous Intraepithelial Lesions of the Cervix

Mitchell, Michele Follen; Tortolero‐Luna, Guillermo; Cook, Elise D.; Whittaker, Lori; Rhodes-Morris, Helen; Silva, Elvio

doi:10.1097/00006254-199902000-00012

Cited by 49 publications

(96 citation statements)

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“…It was unsatisfactory in the other four trials (Alvarez 1994;Duggan 1999;Jobson 1984;Mitchell 1998) as, in at least one of the outcomes, less than 80% of women were assessed at the end point.…”

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

“…to cryotherapy (Berget 1987;Jobson 1984;Kirwan 1985;Kwikkel 1985;Mitchell 1998;Townsend 1983), knife conisations (Bostofte 1986;Kristensen 1990;Larsson 1982;Mathevet 1994), LLETZ using either conisation techniques (Crompton 1994;Mathevet 1994;Oyesanya 1993;Paraskevaidis 1994;Santos 1996;Vejerslev 1999) or laser ablation (Alvarez 1994;Dey 2002;Mitchell 1998) and the different laser techniques (ablation versus conisation (Partington 1989).…”

Section: Description Of Studiesmentioning

confidence: 99%

“…These included comparisons of LLETZ with knife conisation (Duggan 1999;Giacalone 1999Mathevet 1994Takac 1999), cryotherapy (Chirenje 2001), laser conisation techniques (Crompton 1994;Mathevet 1994;Oyesanya 1993;Paraskevaidis 1994;Santos 1996;Vejerslev 1999) or laser ablative techniques (Alvarez 1994;Dey 2002;Mitchell 1998).…”

Section: Description Of Studiesmentioning

confidence: 99%

“…Eight trials included the use of cold coagulation as a technique, comparing this to LLETZ (Chirenje 2001) or laser surgical techniques (Berget 1987;Jobson 1984;Kirwan 1985;Kwikkel 1985;Mitchell 1998;Townsend 1983). A further trial compared differing types of cryotherapy, single versus double freeze techniques (Schantz 1984).…”

Section: Description Of Studiesmentioning

confidence: 99%

“…Sequence generation-Adequacy of randomisation was confirmed in 14 trials (Alvarez 1994;Cherchi 2002;Chirenje 2001;Crompton 1994;Dey 2002;Duggan 1999;Giacalone 1999;Healey 1996;Mathevet 1994;Mitchell 1998;Panoskaltsis 2004a;Santos 1996;Schantz 1984;Vejerslev 1999), where an appropriate method of sequence generation was used to assign women to treatment groups. The method of randomisation was not reported in the other 15 trials.…”

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

See 4 more Smart Citations

Surgery for cervical intraepithelial neoplasia

Martin-Hirsch

Paraskevaidis

Kitchener

1999

Cochrane Database of Systematic Reviews

155

171

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Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

Section: Description Of Studiesmentioning

confidence: 99%

Section: Description Of Studiesmentioning

confidence: 99%

Section: Description Of Studiesmentioning

confidence: 99%

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Surgery for cervical intraepithelial neoplasia

Martin-Hirsch

Paraskevaidis

Kitchener

1999

Cochrane Database of Systematic Reviews

155

171

View full text Add to dashboard Cite

De novo establishment and cost-effectiveness of Papanicolaou cytology screening services in the Socialist Republic of Vietnam

Suba

Hung

Duc

et al. 2001

Cancer

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BACKGROUND Cervical carcinoma is the leading cause of cancer‐related death among women in the developing world. The absence of cervical screening in Vietnam and other developing countries is due in large part to the perceived expense of implementing Papanicolaou cytology screening services, although, to the authors' knowledge, the cost‐effectiveness of establishing such services has never been studied in a developing country. METHODS Using decision analytic methods, the authors assessed cost‐effectiveness of Pap screening from a societal perspective in Vietnam, the world's 9th most populous developing country (estimated 1999 population, 79 million). Outcomes measured included life expectancy, cervical carcinoma incidence, cost per woman, and cost‐effectiveness. RESULTS Total costs to establish a nationwide 5‐year interval Pap screening program in Vietnam will average less than $148,400 annually during the 10‐year time period assumed necessary to develop the program and may be considerably lower if only high risk geographic areas are targeted. Maintenance costs will average less than $0.092 annually per woman in the target screening population. Assuming 70% program participation, cervical carcinoma incidence will decrease from 26 in 100,000 to 14.8 in 100,000, and cost‐effectiveness will be $725 per discounted life‐year. Several assumptions used in this analysis constitute biases against the effectiveness of Pap screening, which in reality may be significantly more cost‐effective than reported here. CONCLUSIONS Contrary to widespread belief, Pap screening in developing countries such as Vietnam is extraordinarily inexpensive and appears to be cost‐effective. Because prospects are uncertain regarding useful alternatives to the Pap test, the evidence‐based argument for establishing conventional Pap screening services in developing countries such as Vietnam is compelling. Population‐based conventional Pap screening services have been established de novo in Vietnam and are now operational. Cancer 2001;91:928–39. © 2001 American Cancer Society.

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De novo establishment and cost‐effectiveness of Papanicolaou cytology screening services in the Socialist Republic of Vietnam

Suba

Hung

Duc

et al. 2001

Cancer

View full text Add to dashboard Cite

Contrary to widespread belief, Pap screening in developing countries such as Vietnam is extraordinarily inexpensive and appears to be cost-effective. Because prospects are uncertain regarding useful alternatives to the Pap test, the evidence-based argument for establishing conventional Pap screening services in developing countries such as Vietnam is compelling. Population-based conventional Pap screening services have been established de novo in Vietnam and are now operational.

show abstract

A Randomized Clinical Trial of Cryotherapy, Laser Vaporization, and Loop Electrosurgical Excision for Treatment of Squamous Intraepithelial Lesions of the Cervix

Cited by 49 publications

References 0 publications

Surgery for cervical intraepithelial neoplasia

Surgery for cervical intraepithelial neoplasia

De novo establishment and cost-effectiveness of Papanicolaou cytology screening services in the Socialist Republic of Vietnam

De novo establishment and cost‐effectiveness of Papanicolaou cytology screening services in the Socialist Republic of Vietnam

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