A Randomized Clinical Trial of a Single Dose of Ramosetron for the Prevention of Vomiting After Strabismus Surgery in Children

Fujii, Yoshitaka; Tanaka, Hiroyoshi; Ito, Mutsuko

doi:10.1001/archopht.123.1.25

Cited by 12 publications

(16 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of PONV in our palonosetron groups was similar to that reported in previous 5-HT 3 inhibitor studies. [21,24,25] The elimination half-life of palonosetron (reported to be approximately 40 hours [13] ) is longer than that of other 5-HT 3 receptor antagonists (e.g. granisetron 5-8 hours, ondansetron 3-5 hours, ramosetron 4.3-9 hours, tropisetron 8 hours).…”

Section: Discussionmentioning

confidence: 99%

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

et al. 2011

View full text Add to dashboard Cite

Background: Postoperative vomiting is a common complication after strabismus surgery in children. The serotonin 5-HT 3 receptor antagonists have proven to be a particularly valuable addition to the armamentarium against postoperative nausea and vomiting (PONV). Palonosetron is a secondgeneration 5-HT 3 receptor antagonist that has recently been approved for prophylaxis against PONV. Objective: The aim of this study was to evaluate the efficacy of different doses of palonosetron for the prevention of PONV in children undergoing strabismus surgery. Patients and Method: A total of 150 children who were classified with an American Society of Anesthesiologists physical status of I, were aged between 2 and 12 years, and were undergoing strabismus surgery under general anesthesia were enrolled in the study. A random numbers table was used to assign each child to receive palonosetron 0.5, 1.0, or 1.5 mg/kg (n = 50 in each group). All episodes of PONV at the intervals of 0-2, 2-6, 6-24, and 24-48 hours were evaluated using a numeric scoring system for PONV. A p-value of <0.05 was considered statistically significant. Results: The percentage of children with PONV during 0-48 hours after anesthesia was 24% with palonosetron 0.5 or 1.0 mg/kg, and 20% with palonosetron 1.5 mg/kg. There was no statistically significant difference between the study groups with respect to the number of children with PONV scores of 1, 2, or 3 during 0-48 hours after anesthesia. There was no statistically significant difference between the study groups with respect to the number of children with postoperative vomiting during all time periods after anesthesia. The percentage of children aged >6 years with postoperative nausea during 0-48 hours after anesthesia was 8.6%, 18.2%, and 15.4% with palonosetron 0.5, 1.0, or 1.5 mg/kg, respectively, but there was no statistically significant difference between the study groups.

show abstract

Section: Discussionmentioning

confidence: 99%

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Also, women are more susceptible to PONV, especially menstruating women, because of a higher level of sexual hormones (e.g., gonadotropin, and mainly progesterone) than in men [2,7,13,16,18]. It is also noteworthy that athletic patients and younger patients, especially children 11 to 16 years of age, are more susceptible to PONV, and the risk decreases with the patientÕs age [4,6,9,15]. In our study, the average age of the patients who underwent surgery was 52.1 years, so age did not constitute a significant risk factor.…”

Section: Discussionmentioning

confidence: 99%

“…These effects may prolong recovery time, delay patient discharge, and increase hospital costs. The incidences of PONV are observed in increased frequency after laparoscopic surgery [3,9].…”

mentioning

confidence: 99%

Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study

2006

View full text Add to dashboard Cite

show abstract

“…The incidence of POV during 0-24 h after anesthesia was 10% with ramosetron 12 mcg kg -1 (P < 0.05), 10% with ramosetron 6 mcg kg -1 (P < 0.05), and 65% with ramosetron 3 mcg kg -1 (P = NS), compared with placebo (75%). They concluded that a 6 mcg kg -1 dose of ramosetron was sufficient [30]. Similarly, prophylactic …”

Section: Prevention Of Pov With Ramosetron In Children (Table 2)mentioning

confidence: 99%

“…A number of clinical studies have shown that prophylactic ramosetron administered IV at the end of surgical procedure reduces the incidence of POV after strabismus surgery and tonsillectomy in children [30][31][32][33]. In a randomized, double-blind, placebo-controlled study, Fujii et al evaluated the efficacy of ramosetron at 3 different doses (3 mcg kg 1 , 6 mcg kg 1 , and 12 mcg kg 1 ) for preventing POV in 80 children (38 boys and 42 girls) undergoing strabismus surgery.…”

Section: Prevention Of Pov With Ramosetron In Children (Table 2)mentioning

confidence: 99%

Current Review of Ramosetron in the Prevention of Postoperative Nausea and Vomiting

Fujii

2011

CDS

Self Cite

View full text Add to dashboard Cite

Formal retraction notice of article entitled Current Review of Ramosetron in the Prevention Of Postoperative Nausea and Vomiting (Curr Drug Saf. 2011 Apr;6(2):122-7) by Dr Y. Fujii. This article is being retracted as a result of: Failure of Dr. Fijii's institution as well as of himself to rationalize the legitimacy of the study and/or its data as stipulated in request by the Editors-in-Chief of the journals extended on April 9, 2012.

show abstract

A Randomized Clinical Trial of a Single Dose of Ramosetron for the Prevention of Vomiting After Strabismus Surgery in Children

Cited by 12 publications

References 10 publications

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

Different Doses of Palonosetron for the Prevention of Postoperative Nausea and Vomiting in Children Undergoing Strabismus Surgery

Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study

Current Review of Ramosetron in the Prevention of Postoperative Nausea and Vomiting

Contact Info

Product

Resources

About