A randomized control trial comparing the efficacy of 3Mixtatin and Modified 3Mix-MP paste using lesion sterilization and tissue repair technique to conventional root canal treatment in primary molars of children aged 4–8 years

Abstract

Background: The aim of this study was to evaluate clinical and radiographic success rates of 3Mixtatin and Modified 3Mix-MP paste and compare it with conventional root canal treatment procedure in primary molars requiring pulpectomy. Materials and Methods: In this in vivo study, 66 primary molars in 52 children aged between 4 and 8 years with primary molars having chronic periapical abscess were treated randomly with 3Mixtatin, Modified 3Mix-MP paste, and Metapex. The subjects were reviewed at 6 and 12 months both clinically and radiographically after pulpal therapy to evaluate and compare the healing process. The data obtained were subjected to statistical analysis at a significance level of 0.05. Results: By the end of 12-month follow-up among the three groups, Group I seemed to be performing consistently better as compared to the other two groups when evaluated clinically and radiographically. However, Group III resulted in the greatest number of failures, with success rate being mere 42.9% at the end of follow-up period. Conclusion: Radiographic and clinical healing occurred in all the three groups; however, based on our results, Group I seemed to be performing consistently better among the three groups at 12-month follow-up. Hence, it can be inferred that 3Mixtatin used as a localized agent is effective and comparable to both Modified 3Mix-MP paste and conventional pulpectomy procedure involving calcium hydroxide and iodoform paste in primary teeth.

Evaluation of the modified 3Mix‐Simvastatin combination in non‐instrumental endodontic therapy of necrotic primary molars: A two‐arm randomized controlled trial

“…In the current study, the modified 3Mix paste was used as the antibacterial agent, while simvastatin played the role of the anti-inflammatory agent, as well as a bone regenerative drug. Simvastatin was added to the paste in the current study to potentially improve the radiographic success rate and promote inter-radicular lesion healing (Aminabadi et al, 2016;Thakur et al, 2021). In dentistry, simvastatin has regenerative effects and improves bone formation by activating osteoblasts while suppressing T A B L E 3 Descriptive statistics of changing in lesion size of necrotic molars in the two groups for both treatment techniques and the p-values of significance testing.…”

“…In the literature, the irrigation protocol varied from no irrigation (Daher et al, 2015) to using copious irrigation with saline (Thakur et al, 2021), NaOCl 2.5% (Zacharczuk et al, 2019), or chlorhexidine 2% (Moura et al, 2021). In the current study, all previous irrigation T A B L E 2 Descriptive statistics of presence or absence the clinical signs and symptoms in the two groups for the two treatment techniques and the p-values of significance testing.…”

“…In the literature, the irrigation protocol varied from no irrigation (Daher et al, 2015 ) to using copious irrigation with saline (Thakur et al, 2021 ), NaOCl 2.5% (Zacharczuk et al, 2019 ), or chlorhexidine 2% (Moura et al, 2021 ). In the current study, all previous irrigation solutions were used to achieve maximal sterilization of the pulp chamber.…”

“…Thakur and colleagues ( 2021 ) conducted a study similar to this one, in which they evaluated the efficacy of a similar mixture to treat chronic necrotic primary molars and compared it with modified mixture of (cefix‐ornidazole‐ciprofloxacin) and Metapex pulpectomy. At the last follow‐up after 1 year, the pulpectomy group showed the greatest number of failures, with a success rate of 42.9%.…”

“…When compared to this study, pulpectomy with ZOE has proved its efficacy with an overall success rate of 85% at the end of the follow‐up period, versus 3Mixtatin, which had a lower success rate of 75% at the 12‐month interval, but this was not statistically significant. Thakur and colleagues ( 2021 ) explained the decreased success rate with Metapex pulpectomy by stating that the use of calcium hydroxide in poor prognosis molars enhanced the inflammatory response, leading to increased root resorption.…”