A Randomized, Controlled, Molecular Study of Condylomata Acuminata Clearance during Treatment with Imiquimod

Tyring, Stephen K.; Arany, István; Stanley, Margaret; Tomai, Mark A.; Miller, Richard L.; Smith, M. Hamblin; McDermott, Daniel; Slade, Herbert B.

doi:10.1086/517472

Cited by 241 publications

(166 citation statements)

References 13 publications

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“…Imiquimod, used as a 5% cream formulation under the trade name Aldara (3M Pharmaceuticals), has been recently approved for the treatment of external genital and perianal warts in humans (23,24). In murine studies, Imiquimod given by topical or intravaginal routes exhibits antiviral (25,26) and antitumor activity (27).…”

Section: Immature DC Injected Into Adjuvant-treated Skin Acquire Migrmentioning

confidence: 99%

Injection of Immature Dendritic Cells into Adjuvant-Treated Skin Obviates the Need for Ex Vivo Maturation

Nair¹,

McLaughlin²,

Weizer

et al. 2003

The Journal of Immunology

154

115

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A key and limiting step in the process of generating human monocyte-derived dendritic cells (DC) for clinical applications is maturation. In the setting of immunotherapy, DC are matured ex vivo by culturing them with various agents that mimic the conditions encountered at a site of inflammation. This study examined whether the ex vivo DC maturation step could be replaced by maturing DC in situ by injecting immature DC into sites pre-exposed to agents that induce a microenvironment conducive to in situ maturation of the injected DC. The hypothesis was that recapitulation of the physiological conditions occurring during pathogen infection would lead to optimal conditions for DC maturation, migration, and function. Murine immature DC injected into adjuvant (Adjuprime, poly-arginine, or Imiquimod)-pretreated skin exhibited lymph node migratory capacity comparable to and immunostimulatory capacity equal to or exceeding that of ex vivo matured DC. Acquisition of migratory capacity did not always correlate with enhanced immunostimulatory capacity. Immunostimulatory capacity was not enhanced when mature DC were injected into adjuvant-pretreated sites and remained below that seen with immature DC matured in situ. Immature DC injected into adjuvant-pretreated sites were more effective than mature DC in stimulating antitumor immunity in mice. 111Indium-labeled human monocyte-derived immature DC injected into adjuvant (Imiquimod)-pretreated sites in cancer patients acquired lymph node migratory capacity comparable to ex vivo matured DC. This study shows that in situ maturation offers a simpler and potentially superior method to generate potent immunostimulatory DC for clinical immunotherapy.

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Section: Immature DC Injected Into Adjuvant-treated Skin Acquire Migrmentioning

confidence: 99%

Injection of Immature Dendritic Cells into Adjuvant-Treated Skin Obviates the Need for Ex Vivo Maturation

Nair¹,

McLaughlin²,

Weizer

et al. 2003

The Journal of Immunology

154

115

View full text Add to dashboard Cite

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“…Tyring and Maymon proposed the first-line use of podophyllin solution or gel [23] [24]. Open Journal of Obstetrics and Gynecology tissues and thus remains effective on young GACs [24].…”

Section: Discussionmentioning

confidence: 99%

Management of Giant Ano-Vulvar Condyloma in a Structure with Limited Resources

Boston¹,

Marc²,

Lydie³

et al. 2017

OJOG

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Buschke-Lowenstein Tumor (BLT) or Giant Acuminate Condyloma (GAC) is an uncommon clinical entity rarely published in Côte d'Ivoire and Africa. It is a viral infection with increasing sexual transmission due to the resurgence of HIV infection. This observation is the first case recorded in our service in three decades. The treatment is resolutely surgical, in our context of sub-medicalization, in the absence of other therapeutic means. Most of the time the progression is favorable, but the prognosis can be aggravated by the HIV coinfection. Through this observation, the authors insist on the prevention of all sexually transmitted infections, particularly, with HPV and HIV, by sexual education (abstinence, fidelity, port of condom) and the systematic vaccination before any sexual activity.

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“…can be used alone or in association to reduce the risk of recurrence [7]. Some authors prefers other treatment such as solution with podofilox solution [14]. Some authors do not prefer harvesting a stoma in these patients, but only prescribing low fibre diet, loperamide and bowel cleansing in post-operative period [15,16].…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Giant Genital Warts

et al. 2014

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Abstract. Giant genital warts (GGW) represent a rare form of sexually transmitted disease caused by the human papillomavirus, arising more frequently in the vulvar and perianal regions as large exophytic cauliflower-like mass. Estimated rate of recurrence is 60 to 66%, while malignant transformation is possible and it has been reported in 30 to 56% of cases. A 45-years-old woman was admitted to our Structure of Plastic and Reconstructive Surgery, Siena, Italy with an extensive cauliflower-like masses diffused on vulvar and perianal region. The patient was treated in general anaesthesia, with a wide en bloc excision up to free clinical edges and immediate reconstruction of the vulvar continuity. Buschke Lowenstein tumour or giant genital warts is a sporadic tumour with an elevate local recurrence rate. In some cases, surgery can be very difficult and it must be associated to other strategies. An accurate follow-up is always necessary.

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A Randomized, Controlled, Molecular Study of Condylomata Acuminata Clearance during Treatment with Imiquimod

Cited by 241 publications

References 13 publications

Injection of Immature Dendritic Cells into Adjuvant-Treated Skin Obviates the Need for Ex Vivo Maturation

Injection of Immature Dendritic Cells into Adjuvant-Treated Skin Obviates the Need for Ex Vivo Maturation

Management of Giant Ano-Vulvar Condyloma in a Structure with Limited Resources

A Case Report of Giant Genital Warts

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