A randomized controlled study of the efficacy of 4 weeks of supplementation with ω-3 polyunsaturated fatty acids in cases of unexplained oligohydramnios

Ismail, Alaa M.; Ramadan, M F; Ali, Mohammed Khairy; Abbas, Ahmed M.; Saman, A M El; Makarem, M.H.

doi:10.1038/jp.2016.134

Cited by 8 publications

(5 citation statements)

References 20 publications

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“…According to a study conducted in Egypt in 2016, omega has successfully increased the amount of amniotic fluid in patients presenting unexplained oligohydramnios. The aforementioned study has also found reduced uterine artery resistance and pulsatility indices; this outcome suggested that the increased amniotic fluid was associated with improved uterine flow [21]. Other studies have also proved that omega improved uterine artery perfusion in non-pregnant patients [22].…”

Section: Discussionmentioning

confidence: 77%

“…This outcome is encouraging and interesting because it allows reasoning about the role played by omega as antioxidant and in reducing inflammatory processes to facilitate placentation and to enable good placental flow for proper fetal growth [1,20]. Such omega performance has been investigated and cited in several studies [21][22][23]. According to a study conducted in Egypt in 2016, omega has successfully increased the amount of amniotic fluid in patients presenting unexplained oligohydramnios.…”

Section: Discussionmentioning

confidence: 93%

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The Effect of Omega/Heparin Association on the Obstetric Outcome of Pregnant Women with Thrombophilia: A Pilot Study

Mendes¹,

Amaral²,

Dornelas³

et al. 2019

Clinics Mother Child Health

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Introduction: It is possible assuming that thrombophilias can change the optimal placental function, as well as lead to infarctions, impaired maternal-fetal exchange mechanisms and even to fetal death. Placental hypoxia determines a vicious cycle comprising oxidative stress, vasoconstriction and impaired fetal oxygenation. Prophylactic heparin use throughout pregnancy has been recommended in some thrombophilia cases because it acts on the coagulation cascade. However, although heparin does not cross the placental barrier and is safe for the fetus, not all patients can use it. Its administration route (parenteral) is not practical and even its prophylactic use is not necessarily harmless, as seen in different thrombocytopenia, gastrointestinal and cerebral bleeding reports. Thus, finding clinical alternatives for these pregnant women would help significantly improving the current medical practice. The use of essential fatty acids (EFAs) is a new perspective that appears to be applicable in daily medical practice, because it facilitates the blood flow and tissue oxygenation, since they reduce vascular resistance and platelet aggregation. Methods: This study is a randomized, controlled, unblind, parallel, three-arm, open-label prevention trial conducted with pregnant women diagnosed with thrombophilia, who were treated in the Obstetrics Services of University Hospitals belonging to UFJF and to Medical School of Barbacena. All the patients were divided in two groups: Group 1=Hereditary thrombophilia patients who used 40 mg of heparin/day (enoxaparin) from the 6th pregnancy week on; Group 2 Patients with acquired or hereditary thrombophilias associated with risk factors for preeclampsia, according to ACOG19 (chronic kidney disease, previous diabetes mellitus, chronic arterial hypertension and collagenoses). Results: The current study assessed 38 pregnant women. Patients' mean age was 32.9 ± 5.0 years. The pulsatility index in the second gestational trimester (24 to 28 weeks) was compared based on treatments. Patients treated with the H+ASA+omega association recorded the lowest pulsatility index; however, there was not statistically significant difference between groups (p>0.05). Uterine artery resistance index in the second gestational trimester (24 to 28 weeks) was also compared based on treatments. Patients treated with the H+ASA+omega association recorded the best resistance index, however, there was not statistically significant difference between groups (p>0.05). The group treated only with heparin recorded the lowest fetal weight, although there was not statistically significant difference between groups. Conclusion: Our results are preliminary, and a crude evaluation of the data shows a decrease in the pulsatility and resistance indices of the uterine art. With the increase of patients in the analysis, we hope that the statistical results can demonstrate this improvement of placental flow.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 93%

The Effect of Omega/Heparin Association on the Obstetric Outcome of Pregnant Women with Thrombophilia: A Pilot Study

Mendes¹,

Amaral²,

Dornelas³

et al. 2019

Clinics Mother Child Health

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“…ОБЗОРЫ эффекты, связанные с приемом омега-3 ПНЖК во время беременности: увеличение объема околоплодных вод при маловодии [18]; эффективная профилактика депрессии во время беременности и после родов [19]; профилактика сниженной массы тела при рождении (в частности, крупномасштабное исследование 12 373 беременных показало, что низкие концентрации омега-3 ПНЖК в плазме крови были связаны с более низкой массой тела новорожденных (отношение шансов 1:4) [4]); снижение риска развития аллергий у детей [20] (например, пищевая аллергия на яйца встречалась только у 9% детей, рожденных от матерей, получавших 900 мг/сут омега-3 ПНЖК во время беременности, а в контроле -у 15% детей). Дети от матерей, получавших дотации омега-3 ПНЖК во время беременности, имели более высокую степень восприятия и воспроизведения речи по шкалам МакАртура и Бейли на 12, 14 и 18-й месяцы жизни [21].…”

Section: The Work Was Done Under Grant 16-07-01129 Of the Rfbrunclassified

New trends in nutritional support for pregnancy

Gromova¹,

Torshin²,

Tetruashvili³

et al. 2018

Akusherstvo i ginekologiia

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ФГБОУ ВО Ивановская государственная медицинская академия Минздрава России, г. Иваново 3 ФГБУ Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова Минздрава России Цель исследования. Провести анализ роли специализированных витаминно-минеральных комплексов (ВМК) в поддержке беременности на основе опубликованных мета-анализов и результатов клинических исследований. Материал и методы. Проведен отбор релевантных публикаций в научной базе цитирования PubMed и, дополнительно в Google Scholar за последние 10 лет. Результаты. Отмечается положительная тенденция отказа от менее усвояемых и, в ряде случаев, более токсических неорганических форм микронутриентов к формам с более высокой биодоступностью. Не менее важными особенностями являются использование биологически активных форм микронутриентов и все более широкое применение омега-3 полиненасыщенных жирных кислот в составе ВМК для беременных. Заключение. Применение ВМК у беременных с высокой биодоступностью позволяет осуществить первичную профилактику пороков развития плода. Наличие в составе ВМК омега-3 полиненасыщеных жирных кислот снижает риск развития нарушений функции зрения и перинатальной энцефалопати у плода. Ключевые слова: нутрициальная поддержка беременности, профилактика врожденных пороков, липофер, метилфолиевая кислота, докозагексаеновая кислота, прегнотон мама. Работа выполнена по гранту 16-07-01129 РФФИ. Авторы заявляют об отсутствии возможных конфликтов интересов.

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“…The free radicals release during pregnancy impairs vascular endothelial function and subsequent vasoconstriction will occur [11] . Omega-3 fatty acids, as antioxidants, inhibit free radicals release; this leads to an increase in the blood flow to the uterus and placenta which may improve pregnancy outcomes [12] . The effectiveness of omega-3 fatty acids on the birth weight of IUGR was studied before with promising results [9] .…”

Section: Introductionmentioning

confidence: 99%

The Effect of Adding Vaginal Progesterone to Oral Omega-3 Fatty Acids on the Birth Weight of Constitutionally Small for Gestational Age Fetuses: A Randomized Clinical Trial

Ali,

Hussein,

Ali

et al. 2024

Evidence Based Women's Health Journal

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Aim: To investigate the effectiveness of adding vaginal progesterone to oral omega-3 fatty acids on the birth weight of constitutionally small for gestational age fetuses (SGA). Materials and Methods:The study was a randomized clinical trial conducted from May 2020 to June 2022 at Assiut Woman's Health Hospital, Egypt including pregnant women in singleton fetuses (26-28 weeks) whose pregnancy was associated with constitutionally SGA fetuses. The eligible women were randomized to either group I (oral omega-3 fatty acids group) or group II (vaginal progesterone plus oral omega-3 fatty acids group); given daily till delivery. The primary outcome was the mean birth weight (gm) at the time of delivery. The data were analyzed using an unpaired t-test and the Chi-square test. Results: Eighty women were divided equally into two groups. There was a statistically significant increase in the mean birth weight (gm) at the time of delivery in group II in comparison to group I (1762.74 ± 80.06 vs. 1852.94 ± 71.71, receptively; p=0.000). The mean of uterine artery resistant index (RI) has a statistically significant decrease at 32 weeks and 36 weeks (p value=0.000) and the mean of umbilical artery RI has a statistically significant decrease at 36 weeks (p value=0.001) in group II. Conclusion: Adding vaginal progesterone to oral omega-3 fatty acids is superior to oral omega-3 fatty acids alone in increasing the birth weight of constitutionally SGA fetuses when given from 26-28 weeks gestation till delivery. The improvement of the feto-maternal blood flow may be behind the treatment result.

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A randomized controlled study of the efficacy of 4 weeks of supplementation with ω-3 polyunsaturated fatty acids in cases of unexplained oligohydramnios

Abstract: The results suggest that ω-3 fatty acids may have a role in the increase in AFI in cases of unexplained oligohydramnios. This effect may be secondary to the increase in uterine blood flow.

Cited by 8 publications

References 20 publications

The Effect of Omega/Heparin Association on the Obstetric Outcome of Pregnant Women with Thrombophilia: A Pilot Study

The Effect of Omega/Heparin Association on the Obstetric Outcome of Pregnant Women with Thrombophilia: A Pilot Study

New trends in nutritional support for pregnancy

The Effect of Adding Vaginal Progesterone to Oral Omega-3 Fatty Acids on the Birth Weight of Constitutionally Small for Gestational Age Fetuses: A Randomized Clinical Trial

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