A Randomized Controlled Study of Effects of Dietary Magnesium Oxide Supplementation on Bone Mineral Content in Healthy Girls

Carpenter, Thomas O.; DeLucia, Maria C.; Zhang, Jane Hongyuan; Bejnerowicz, Gina; Tartamella, L.; Dziura, James; Petersen, Kitt Falk; Befroy, Douglas E.; Cohen, Dorothy

doi:10.1210/jc.2006-1391

Cited by 74 publications

(37 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Aydin and colleagues (2010) reported the effects of Mg supplementation on bone turnover suppression in postmenopausal women [4]. Also, the positive effects of Mg supplementation on hip BMC in peri-adolescent girls has been previously documented [5]. Meanwhile, higher Mg intake from foods or supplements may parallel higher intake of nutrients thought to be beneficial to bone health [14,24,25].…”

Section: Discussionmentioning

confidence: 99%

“…Previous research has also shown the effects of Mg supplementation on bone turnover suppression in postmenopausal women [4]. It was reported that a positive effect of Mg supplementation on hip bone mineral content (BMC) was evident in periadolescent girls [5]. However, previous studies regarding Mg supplementation and bone health are mostly about postmenopausal women or OVX animal models, both of which have high risk for osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Magnesium Intake and Its Relation with Bone Quality in Healthy Young Korean Women

Kim

Yeon

Choi

et al. 2011

Biol Trace Elem Res

View full text Add to dashboard Cite

Many studies have reported magnesium's role in nutrition as a vital factor involved in bone health. However, not enough studies have evaluated magnesium (Mg) intakes in young women. In this study, we evaluated Mg intake in healthy adults and its relation with bone quality. A total of 484 healthy young women in their early 20s were enrolled into the study. Anthropometric measurements, dietary intake survey using 3-day dietary records, and the bone quality of the calcaneus using quantitative ultrasounds were obtained and analyzed. Average age, height, and weight of the subjects were respectively 20.20 years, 161.37 cm, and 54.09 kg, respectively. Also, the average broadband ultrasound attenuation, speed of sound (SOS), stiffness index (SI), and calcaneus T scores were 114.32 dB/MHz, 1,568.45 m/s, 95.23, and 0.36 g/cm(2), respectively. The subject's average intake of energy was 1,543.19 kcal, and the average Mg intake was 185.87 mg/day. Mg intake per 1,000 kcal of consumed energy in our subjects was 119.85 mg. Subjects consumed 63.11% of the recommended intake for Mg. Food groups consumed with high Mg content in our subjects included cereals (38.62 mg), vegetables (36.97 mg), milk (16.82 mg), legumes (16.72 mg), and fish (16.50 mg). The level of Mg intake per 1,000 kcal showed significant correlation to the SOS in the calcaneus (r = 0.110, p < 0.05) after adjustment for age, BMI, and percent body fat. In addition, the intakes of Mg from potatoes (p < 0.001), legumes (p < 0.05), and fungi and mushrooms (p < 0.05) positively correlated with the SOS of the calcaneus. In conclusion, the magnesium intake status of young Korean women aged 19-25 years is unsatisfactory. Improving dietary intake of Mg may positively impact bone quality in this population.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Magnesium Intake and Its Relation with Bone Quality in Healthy Young Korean Women

Kim

Yeon

Choi

et al. 2011

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Захисна дія підвищеного надходження Mg на якість КТ була задокументована у здорових жінок за допомогою методу ультразвукового вимірювання щільності п'яткової кістки [26]. Позитивний ефект додавання Mg на накопичення кісткової маси стегнової кістки показаний групою авторів на практично здорових дівчатах [27].…”

Section: зміни стану кісткової тканини за умов надмірного вмісту Mgunclassified

Effect of magnesium on bone tissue remodeling

Litovka¹,

Березовский²

2018

Fiziol Zh

View full text Add to dashboard Cite

“…Also in humans magnesium deficiency contributes to osteoporosis; in Framingham study magnesium intake was positively associated with bone mass density (25). Recently, the protective effect of high magnesium intake on bone quality was documented in healthy women using ultrasound measurement in calcaneus (26) and a trial shows a positive effect of magnesium supplementation on the accrual of bone mass in the hip of young women (27). Several direct and indirect mechanisms contribute to the effects of low magnesium on bone density: low magnesium can directly affect the bone by altering the structure of apatite crystals; magnesium deficiency is also associated with reduction of PTH and 1,25(OH 2 ) D levels and low grade inflammation and endothelial dysfunction, with a well-known relation between inflammation and bone loss (28).…”

Section: Magnesiummentioning

confidence: 99%

Microelements for bone boost: the last but not the least

Pepa

Brandi

2016

ccmbm

View full text Add to dashboard Cite

SummaryOsteoporosis is a major public health problem affects many millions of people around the world. It is a metabolic bone disease characterized by loss of bone mass and strength, resulting in increased risk of fractures. Several lifestyle factors are considered to be important determinants of it and nutrition can potentially have a positive impact on bone health, in the development and maintenance of bone mass and in the prevention of osteoporosis. There are potentially numerous nutrients and dietary components that can influence bone health, and these range from the macronutrients to micronutrients. In the last decade, epidemiological studies and clinical trials showed micronutrients can potentially have a positive impact on bone health, preventing bone loss and fractures, decreasing bone resorption and increasing bone formation. Consequently, optimizing micronutrients intake might represent an effective and low-cost preventive measure against osteoporosis.

show abstract

A Randomized Controlled Study of Effects of Dietary Magnesium Oxide Supplementation on Bone Mineral Content in Healthy Girls

Abstract: Oral Mg oxide capsules are safe and well tolerated. A positive effect of Mg supplementation on integrated hip BMC was evident in this small cohort.

Cited by 74 publications

References 27 publications

Evaluation of Magnesium Intake and Its Relation with Bone Quality in Healthy Young Korean Women

Evaluation of Magnesium Intake and Its Relation with Bone Quality in Healthy Young Korean Women

Effect of magnesium on bone tissue remodeling

Microelements for bone boost: the last but not the least

Contact Info

Product

Resources

About