A randomized, controlled trial comparing topical steroid application to wet versus dry skin in children with atopic dermatitis (AD)

Kohn, Lucinda L.; Kang, Yanna; Antaya, Richard J.

doi:10.1016/j.jaad.2016.04.060

Cited by 21 publications

(10 citation statements)

References 13 publications

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“…Wet‐wrap medications are highly effective in acute AE and improve tolerance. The use of wet‐wrap dressings with diluted corticosteroids for up to 14 days (usual is rather up to 3 days) may be a safe crisis intervention treatment of severe and/or refractory AE with temporary systemic bioactivity of the corticosteroids as the only reported serious side‐effects . However, this treatment approach is not standardized yet, and the evidence that it is more effective than conventional treatment with topical steroids in AE is not of high quality.…”

Section: Topical Anti‐inflammatory Therapymentioning

confidence: 99%

“…The use of wet-wrap dressings with diluted corticosteroids for up to 14 days (usual is rather up to 3 days) may be a safe crisis intervention treatment of severe and/or refractory AE with temporary systemic bioactivity of the corticosteroids as the only reported serious side-effects. [102][103][104][105] However, this treatment approach is not standardized yet, and the evidence that it is more effective than conventional treatment with topical steroids in AE is not of high quality. Simple or occlusive medications in less sensitive skin areas and for brief time periods may also increase efficacy and speed up lesion resolution.…”

Section: Topical Anti-inflammatory Therapymentioning

confidence: 99%

See 1 more Smart Citation

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I

Wollenberg

Barbarot

Bieber³

et al. 2018

Acad Dermatol Venereol

869

1,014

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This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This first part of the guideline covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy, whereas the second part covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions. Management of AE must consider the individual clinical variability of the disease; highly standardized treatment rules are not recommended. Basic therapy is focused on treatment of disturbed barrier function by hydrating and lubricating topical treatment, besides further avoidance of specific and unspecific provocation factors. Topical anti-inflammatory treatment based on glucocorticosteroids and calcineurin inhibitors is used for flare management and for proactive therapy for long-term control. Topical corticosteroids remain the mainstay of therapy, whereas tacrolimus and pimecrolimus are preferred in sensitive skin areas and for long-term use. Topical phosphodiesterase inhibitors may be a treatment alternative when available. Adjuvant therapy includes UV irradiation, preferably with UVB 311 nm or UVA1. Pruritus is targeted with the majority of the recommended therapies, but some patients may need additional antipruritic therapy. Antimicrobial therapy, systemic anti-inflammatory treatment, immunotherapy, complementary medicine and educational intervention will be addressed in part II of the guideline.

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Section: Topical Anti‐inflammatory Therapymentioning

confidence: 99%

Section: Topical Anti-inflammatory Therapymentioning

confidence: 99%

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I

Wollenberg

Barbarot

Bieber³

et al. 2018

Acad Dermatol Venereol

869

1,014

View full text Add to dashboard Cite

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“…25,26 Previous studies have shown good efficacy for soak and smears, 27e29 although a recent RCT found no greater efficacy than topical corticosteroid on dry skin. 30 Water baths alone or the soak and smear regimen can be effective without the addition of bleach. Bleach baths are commonly recommended because they are inexpensive, relatively safe, and easily accessible.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of bleach baths in reducing severity of atopic dermatitis: A systematic review and meta-analysis

Chopra

Vakharia

Sacotte

et al. 2017

Annals of Allergy, Asthma & Immunology

104

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“…As to therapy of (atopic) eczema, some controversy was stirred by a recent paper showing application of topical steroids on presoaked skin (wet-wrap technique) not achieving improved outcome than application of topical steroids on dry skin [40].…”

Section: Current Controversiesmentioning

confidence: 99%

Allergic contact dermatitis

Slavin

Ducomb²

2019

Pediatric Dermatology

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Allergic contact dermatitis (ACD) is a common skin disease caused by a T cell-mediated immune reaction to usually innocuous allergens. ACD can have grave medical and socioeconomic consequences. ACD and irritant contact dermatitis often occur together. A detailed history and clinical examination are crucial and guide patch testing, which is the gold standard to diagnose ACD. T-cell clones persisting in the skin may explain the tendency of ACD to relapse even after years of allergen avoidance. Traditional treatments for ACD are topical steroids, calcineurin inhibitors, phototherapy, retinoids (including the recent alitretinoin), and immunosuppressants. Targeted therapies are lacking.

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A randomized, controlled trial comparing topical steroid application to wet versus dry skin in children with atopic dermatitis (AD)

Cited by 21 publications

References 13 publications

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I

Efficacy of bleach baths in reducing severity of atopic dermatitis: A systematic review and meta-analysis

Allergic contact dermatitis

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