A Randomized, Controlled Trial of Poractant Alfa versus Beractant in the Treatment of Preterm Infants with Respiratory Distress Syndrome

Dizdar, Evrim Alyamaç; Sarı, Fatma Nur; Aydemir, Cumhur; Oğuz, Şerife Suna; Erdeve, Ömer; Uraş, Nurdan; Dilmen, Uğur

doi:10.1055/s-0031-1295648

Cited by 52 publications

(62 citation statements)

References 18 publications

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“…Different surfactants might vary in their suitability for nebulization, which is reflected by the great quantity of different preparations of surfactant that have been tested in both animal and clinical studies (12). In our study, we used Poractant alfa, an animal-derived surfactant which proved to be advantageous compared to different surfactant preparations regarding rapid onset of action, less need for redosing, and higher survival free of BPD in preterm infants (28), and regarding mortality (29) after bolus administration. Recently, an artificial surfactant aerosolized in a piglet model of acute lung injury resulted in improved gas exchange (30).…”

Section: Surfactant Distribution Relative To Wholementioning

confidence: 99%

Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation

et al. 2015

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Section: Surfactant Distribution Relative To Wholementioning

confidence: 99%

Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation

et al. 2015

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“…2,4 Given that mobile phones are now an integral part of most hospitals, guidelines for decontamination of mobile phones should be developed.…”

Section: Referencesmentioning

confidence: 99%

“…1 As with other environmental surfaces, prior studies have suggested that mobile phones may serve as a reservoir for pathogenic bacteria. 2 Given the difference in bacterial epidemiology, it is of interest to evaluate the type of bacteria found on the mobile phones of healthcare workers in a paediatric ward.…”

Section: Dear Editor Mobile Phones As a Potential Vector Of Infectiomentioning

confidence: 99%

“…3 This pilot study adds to the growing body of evidence that suggests that phones act as a vector for pathogenic organisms. 2,4 Given that mobile phones are now an integral part of most hospitals, guidelines for decontamination of mobile phones should be developed.…”

Section: Dear Editor Mobile Phones As a Potential Vector Of Infectiomentioning

confidence: 99%

“…Recently, we have prospectively evaluated the differences in clinical responses and short-term outcomes in 126 preterm infants with respiratory distress syndrome (RDS) randomised to treatment with poractant (n = 61) or beractant (n = 65). 2 Patients were followed until 40 weeks of corrected gestational age or death. Significantly, more patients in the beractant group required two doses of surfactant compared with the poractant group (31% vs. 12%, P = 0.023).…”

Section: Poractant Alfa Versus Beractant In the Treatment Of Preterm mentioning

confidence: 99%

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Mobile phones as a potential vector of infection in a paediatric ward

Foong

Green

Ogden

2013

J Paediatrics Child Health

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References2 Given the difference in bacterial epidemiology, it is of interest to evaluate the type of bacteria found on the mobile phones of healthcare workers in a paediatric ward.Forty mobile phones were sampled over a 3-month period. These were taken from medical students (n = 18), resident medical officers (n = 10), registrars (n = 8) and consultants (n = 4). Self-reported frequency of mobile phone use averaged at once every 70.5 ± 57.0 (standard deviation) min. Out of these, 27 had phone covers, and the most common location our participants carried their phones was in their pockets (n = 28), followed by their hand bags (n = 10) and belt pouches (n = 2). Four reported cleaning their phones in the past 48 h, and 10 cleaned them regularly. None of our subjects cleaned their phones with alcohol wipes. Table 1 illustrates the bacterial organisms isolated from the samples. Out of 40 samples taken from mobile phones, 38 (95%) were contaminated with bacteria (Table 1). Twenty (50%) had one bacterial species, 17 (42.5%) had two and only 1 (2.5%) had three. The types of microorganisms isolated from mobile phones and dominant hands were similar.Those with >100 colonies were categorised as having 'heavy growth', and logistic regression was performed to explore the relationship between heavy growth and phone user characteristics. We found that medical students had greater odds of having heavy growth (odds ratio (OR) = 4.05, confidence interval (CI) 1.02-16.015, P value = 0.046). When frequency of use was taken into account, the strength of the association remained similar and approached significance (OR = 3.76, CI 0.93-15.17, P value = 0.063). Seniority, presence of a phone cover, phone location and phone cleaning showed no significant associations with the level of growth (data not shown).In this pilot study, the use of mobile phones by staff in the paediatric ward demonstrated a high contamination rate, mostly with skin flora. Currently, there are no evidence-based guidelines for the use of mobile phones in hospitals.3 This pilot study adds to the growing body of evidence that suggests that phones act as a vector for pathogenic organisms. 2,4 Given that mobile phones are now an integral part of most hospitals, guidelines for decontamination of mobile phones should be developed.We believe that our study is the first to suggest that there may be greater contamination of mobile phones used by medical students. This was not fully explained by the inclusion of phone use frequency in the model. Given the widespread use of mobile phones, these findings should be confirmed by a larger study. AcknowledgementThe authors would like to thank Mr Ahmad Zargari, Dr Terry Brain and Dr Mhisti Rele for their assistance. Role of Funding SourceThis work was supported by the School of Medicine, University of Tasmania. The study sponsor had no role in the design of the study; the collection, analysis and interpretation of the data; or the writing of the article and the decision to submit it for publication. The researchers work independen...

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Pulmonary-Respiratory Medicine

2001

JAMA

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A Randomized, Controlled Trial of Poractant Alfa versus Beractant in the Treatment of Preterm Infants with Respiratory Distress Syndrome

Cited by 52 publications

References 18 publications

Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation

Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation

Mobile phones as a potential vector of infection in a paediatric ward

Pulmonary-Respiratory Medicine

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