A randomized controlled trial of green tea catechins in protection against ultraviolet radiation–induced cutaneous inflammation

Farrar, Mark D.; Nicolaou, Anna; Clarke, Kayleigh A.; Mason, Sarah; Massey, Karen A.; Dew, Tristan P.; Watson, Rachel; Williamson, Gary; Rhodes, Lesley E.

doi:10.3945/ajcn.115.107995

Cited by 53 publications

(62 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…15 Farrar et al 16 conducted a randomized, placebo-controlled trial using systemic green tea to evaluate its effects on minimal erythema dose (MED). MED is the lowest UV dose that produces visually detectable skin erythema.…”

Section: Green Teamentioning

confidence: 99%

See 1 more Smart Citation

Systematic Review of Oral and Topical Botanicals in Reducing Photosensitivity

Saric¹,

Clark²,

Sivamani³

2017

Dermatol Open J

View full text Add to dashboard Cite

CitationSaric S, Clark AK, Sivamani RK. Systematic review of oral and topical botanicals in reducing photosensitivity. Dermatol Open J. 2017; 2(2): 21-30. doi: 10.17140/DRMTOJ-2-124 ABSTRACT Objectives: Various treatment options are available for the management of photosensitivity. The objective of this review is to evaluate the use of botanicals rich in antioxidants for photosensitivity reduction. Design: Embase and Ovid/MEDLINE databases were searched for clinical studies evaluating antioxidants from botanical sources in the management of photosensitivity. Results: Of 339 citations, 10 met the inclusion criteria. Four studies evaluated Polypodium leucotomos, two evaluated Camelia sinensis, while Hamamelis, Pistacia vera L., Citrus sinensis varieties Moro, Tarocco and Sanguinello, and Capparis spinosa were investigated in one study each. Five studies evaluated oral supplementation, four evaluated topical formulations, and one study evaluated both oral and topical antioxidants. Main results were summarized. Conclusions: There is some evidence that antioxidants derived from botanical sources may be beneficial in reducing skin erythema and photosensitivity. However, the studies included in this review have methodological limitations and large scale randomized, placebo controlled trials are needed to further evaluate the efficacy and safety of botanical antioxidants in photosensitivity reduction.

show abstract

Section: Green Teamentioning

confidence: 99%

“…MED is the lowest UV dose that produces visually detectable skin erythema. Fifty subjects aged 18-65 years ("nearly all females") 16 were randomly assigned to consume 1080 mg green tea catechins daily or placebo capsules. At baseline and 12 weeks post-supplementation, buttock skin was exposed to UV radiation and MED was recorded.…”

Section: Green Teamentioning

confidence: 99%

Systematic Review of Oral and Topical Botanicals in Reducing Photosensitivity

Saric¹,

Clark²,

Sivamani³

2017

Dermatol Open J

View full text Add to dashboard Cite

show abstract

“…Similarly, clinical trials examining the photoprotective effect of oral green tea administration have yielded conflicting results [32,36,37,38]. Furthermore, clinical and epidemiological studies investigating the biological effects of orally administered green tea tend to produce inconclusive results in general, regardless of the topic of investigation [39,40].…”

Section: Introductionmentioning

confidence: 99%

A Randomized Controlled Trial of Green Tea Beverages on the in vivo Radical Scavenging Activity in Human Skin

Megow¹,

Darvin²,

Meinke³

et al. 2017

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Background: Oxidative stress plays an important role in the pathogenesis of various skin diseases. Thus, the antioxidant network of the skin relies on the uptake of exogenous antioxidants to ensure cell protection against radical formation. Green tea is one of the main sources of polyphenolic antioxidant compounds, but only few data are available on its cutaneous antioxidant effects. Methods: The radical scavenging properties of Benifuuki and Yabukita green tea were investigated in the human skin. Thirty-two participants who met the inclusion criteria were randomized to consume 3 cups per day of either Benifuuki tea, Yabukita tea, or water (control group) for 2 weeks. Electron paramagnetic resonance (EPR) spectroscopy was applied to measure the radical scavenging capacity of the skin in vivo before and after the intervention. Results: Both Yabukita and Benifuuki tea led to an increase in the radical scavenging activity of the skin by 28 and 29%, respectively, and the difference was significant when compared to the control group. Benifuuki tea, previously reported to be superior in bioavailability due to a highly absorbable methylated catechin, did not prove to be more effective than the common Yabukita tea. Conclusion: The results show that green tea enhances the radical scavenging capacity of the skin and support the hypothesis that green tea may offer protection against cutaneous oxidative stress.

show abstract

“…We performed a double-blind, randomized, placebo-controlled trial in healthy white adults (13 male and 37 female; 18-65 years of age; Fitzpatrick skin phototypes I and II) who received 1080 mg GTC (equivalent to 5 cups/day) with 100 mg vitamin C (n = 25) or placebo maltodextrin (n = 25) daily for 12 weeks 3 . Vitamin C was used as previously 3 to stabilize GTC in the gut lumen 4 .…”

mentioning

confidence: 99%

“…Vitamin C was used as previously 3 to stabilize GTC in the gut lumen 4 . A high dose proinflammatory (3 × minimal erythema dose [MED]) challenge with solar simulated UVR (5% UVB, 95% UVA) was applied to buttock skin pre- and postsupplementation.…”

mentioning

confidence: 99%