A randomized, double‐blind, placebo‐controlled clinical trial on the efficacy and safety of 3% <i><scp>R</scp>umex occidentalis</i> cream versus 4% hydroquinone cream in the treatment of melasma among <scp>F</scp>ilipinos

Mendoza, Clarisse Garcia; Singzon, Ivan A.; Handog, Evangeline B.

doi:10.1111/ijd.12690

Cited by 29 publications

(24 citation statements)

References 15 publications

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“…Few studies were excluded as full text were not available. Finally, 11 studies, including 9 randomized controlled trials (RCTs), were evaluated that used 4% HQ among 735 subjects[ 22 23 24 25 26 27 28 29 30 31 32 33 ] [ Table 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…A single study reported lesser efficacy when compared to 3% rumex occidentalis[ 28 ] (LOE-2) and 1% flutamide[ 29 ] (LOE-2). No further studies substantiated these findings however.…”

Section: Introductionmentioning

confidence: 99%

“…[ 22 23 ] Some studies have continued till 24 weeks without any report of AE. [ 27 28 ] None of the studies included dermal melasma in study subjects.…”

Section: Introductionmentioning

confidence: 99%

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Evidence-based review, grade of recommendation, and suggested treatment recommendations for melasma

Sarma

Chakraborty

Poojary

et al. 2017

Indian Dermatol Online J

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Treatment of melasma is known to be less satisfactory, often incomplete, and relapse is frequent. Although many treatment options are available, they are either known to be unsafe on long-term use or their long-term safety profile is unknown. Patients often use various drugs, even topical steroid-based preparation without any medical supervision for long period of time, making the skin unsuitable for many of the drugs available. Thus, there has been gross disparity among the treating physician about what drugs and what regimen are best suitable for various categories of melasma patients and in different situations. With this background, numerous newer drugs, mostly combinations of some proprietary molecules or even unknown plant extracts, have flooded the market for the management of melasma. Information on efficacy or safety of these products are almost unknown. Studies on Asian people, especially Indian population, are far less commonly available. Therapeutic guideline for use on Indian patients with melasma is almost missing. Extrapolation of data from Caucasian people for use on Asian people may not be scientifically justifiable because Caucasian and Asian people are known to have inherent difference in their response as well as tolerance to the drugs used for melasma. With this background, we have extensively evaluated, following a strict, scientifically designed protocol, all the available studies on melasma management till May 2016 and prepared this document on level of evidence, grade of recommendation and suggested therapeutic guideline for melasma as per the method proposed by Oxford Centre of Evidence-Based Medicine. Various ethical, social, logical, regional, and economic issues in the context of Indian and similar populations were given due importance while preparing the suggested therapeutic recommendation.

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Section: Introductionmentioning

confidence: 99%

“…A single study reported lesser efficacy when compared to 3% rumex occidentalis[ 28 ] (LOE-2) and 1% flutamide[ 29 ] (LOE-2). No further studies substantiated these findings however.…”

Section: Introductionmentioning

confidence: 99%

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Evidence-based review, grade of recommendation, and suggested treatment recommendations for melasma

Sarma

Chakraborty

Poojary

et al. 2017

Indian Dermatol Online J

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“…The formulation was applied twice a day for a period of 8 weeks, with examinations every 2 weeks using a Mexameter ® system. The results indicate that while similar declines in skin pigmentation were observed for both 3% sorrel extract and 4% hydroquinone, sorrel extract proved to be a safe and effective means of lightening discoloration in melasma …”

Section: Discussionmentioning

confidence: 96%

The assessment of the effect of a cosmetic product brightening the skin of people with discolorations of different etiology

Zasada

Dębowska

Pasikowska

et al. 2016

J of Cosmetic Dermatology

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“…So wurde z. B. für Rumex occidentalis in einer doppelblind durchgeführte Studie gezeigt, dass es bei Melasma eine vergleichbare Wirkung zu Hydroquinone aufweist . Bei Aphten scheint ein Extrakt aus Alhagistrauch eine Wirkung zu erzielen – ebenfalls getestet in eine doppelblind Studie .…”

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Phytotherapie in der Dermatologie – natürlich gut?!

Traidl‐Hoffmann

2016

J Deutsche Derma Gesell

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A randomized, double‐blind, placebo‐controlled clinical trial on the efficacy and safety of 3% Rumex occidentalis cream versus 4% hydroquinone cream in the treatment of melasma among Filipinos

Abstract: Rumex occidentalis 3% cream is a safe and effective skin-lightening agent for melasma and is comparable in efficacy with 4% HQ cream.

Cited by 29 publications

References 15 publications

Evidence-based review, grade of recommendation, and suggested treatment recommendations for melasma

Evidence-based review, grade of recommendation, and suggested treatment recommendations for melasma

The assessment of the effect of a cosmetic product brightening the skin of people with discolorations of different etiology

Phytotherapie in der Dermatologie – natürlich gut?!

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