A randomized, double-blind, placebo-controlled pilot study to assess bacterial anti-adhesive activity in human urine following consumption of a cranberry supplement

Liu, Haiyan; Howell, Amy B.; Zhang, Derek J.; Khoo, Christina

doi:10.1039/c9fo01198f

Cited by 40 publications

(33 citation statements)

References 48 publications

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“…The main efficacy is related to the antiadherence properties of cranberry (Ahuja et al, 1998;Liu et al, 2006) due to the A-type proanthocyanidin (PAC-A) that has been shown to be an important inhibitor of Type-I fimbriae E. coli adhesion to uroepithelial cells. Some in vitro and in vivo studies demonstrated the capacity of the cranberry to reduce the adhesion of bacteria to the cells (Ermel et al, 2012;Rafsanjany et al, 2015;Liu et al, 2019). Cranberry has also shown convincing results on motility and biofilm formation.…”

Section: Cranberry (Vaccinium Macrocarpon)mentioning

confidence: 99%

“…Cranberry (Ahuja et al, 1998;Howell et al, 2005;Freitas et al, 2006;Liu et al, 2006Liu et al, , 2019AFSSA, 2007;Jepson and Craig, 2008;Pereira et al, 2011;Ermel et al, 2012;Jepson et al, 2012;Stapleton et al, 2012;Chan et al, 2013;Boonsai et al, 2014;Olczyk et al, 2014;Ulrey et al, 2014;Rafsanjany et al, 2015;Rodríguez-Pérez et al, 2016;Wojnicz et al, 2016;Pasupuleti et al, 2017;Ranfaing et al, 2018a,b;Anger et al, 2019;Bruyère et al, 2019) • Reduction of adhesion, motility, and biofilm formation…”

Section: Nutraceuticalmentioning

confidence: 99%

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Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections

et al. 2020

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Urinary tract infections (UTIs) mainly caused by Uropathogenic Escherichia coli (UPEC), are common bacterial infections. Many individuals suffer from chronically recurring UTIs, sometimes requiring long-term prophylactic antibiotic regimens. The global emergence of multi-drug resistant uropathogens in the last decade underlines the need for alternative non-antibiotic therapeutic and preventative strategies against UTIs. The research on non-antibiotic therapeutic options in UTIs has focused on the following phases of the pathogenesis: colonization, adherence of pathogens to uroepithelial cell receptors and invasion. In this review, we discuss vaccines, small compounds, nutraceuticals, immunomodulating agents, probiotics and bacteriophages, highlighting the challenges each of these approaches face. Most of these treatments show interesting but only preliminary results. Lactobacillus-containing products and cranberry products in conjunction with propolis have shown the most robust results to date and appear to be the most promising new alternative to currently used antibiotics. Larger efficacy clinical trials as well as studies on the interplay between non-antibiotic therapies, uropathogens and the host immune system are warranted.

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Section: Cranberry (Vaccinium Macrocarpon)mentioning

confidence: 99%

Section: Nutraceuticalmentioning

confidence: 99%

Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections

et al. 2020

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“…A RCT demonstrated the ability of type A proanthocyanidins of cranberry to inhibit the ex vivo adherence of both P-type and type 1 uropathogenic E. coli ( Figure 3 ) [ 76 ]. A similar result was obtained against Candida albicans strain, with a significant reduction in the adherence and biofilm formation after cranberry supplementation [ 77 ].…”

Section: Methodsmentioning

confidence: 99%

Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications

et al. 2021

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Cranberry is a fruit originally from New England and currently growing throughout the east and northeast parts of the USA and Canada. The supplementation of cranberry extracts as nutraceuticals showed to contribute to the prevention of urinary tract infections, and most likely it may help to prevent cardiovascular and gastroenteric diseases, as highlighted by several clinical trials. However, aiming to validate the efficacy and safety of clinical applications as long-term randomized clinical trials (RCTs), further investigations of the mechanisms of action are required. In addition, a real challenge for next years is the standardization of cranberry’s polyphenolic fractions. In this context, the optimization of the extraction process and downstream processing represent a key point for a reliable active principle for the formulation of a food supplement. For this reason, new non-conventional extraction methods have been developed to improve the quality of the extracts and reduce the overall costs. The aim of this survey is to describe both technologies and processes for highly active cranberry extracts as well as the effects observed in clinical studies and the respective tolerability notes.

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“…In fact, numerous ex vivo studies have confirmed the antiadhesive activity of urine samples collected from volunteers who consumed cranberry products in comparison to urine samples collected from the placebo group. As example of this, a recent study demonstrates the strong ability of human urine after intake of a cranberry chew compared to a placebo chew to inhibit the ex vivo adherence of both P type and type 1 uropathogenic E. coli in a randomized, double-blind, placebo-controlled, crossover design pilot trial [20]. In the same way, Baron et al [59] reported a significant reduction in the adherence and biofilm formation of a Candida albicans strain by urine collected after the intake of a cranberry extract and a lecithin formulation with improved oral bioavailability.…”

Section: Antiadherence Activity Derived From Cranberry Consumptionmentioning

confidence: 99%

“…Although the consumption of cranberries (Vaccinium macrocarpon) has been extensively recommended for UTIs prophylaxis and relief of adverse symptoms, the UTIs preventive activity of cranberry has been debated in the literature and numerous clinical studies have been carried out, including some recent meta-analyses [4,12,13]. Several studies have shown a protective effect of cranberry against UTIs [14][15][16][17][18]; nevertheless, others have not found significant effects [19,20]. This current controversy about conflicting results of the clinical and cost effectiveness of cranberry supplements has been attributed to different manufactured cranberry based products and doses, as well as a lack of systematic protocol for the selection of subjects and clinical assay [13].…”

Section: Introductionmentioning

confidence: 99%

Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations

2020

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Cranberry (Vaccinium macrocarpon) is a distinctive source of polyphenols as flavonoids and phenolic acids that has been described to display beneficial effects against urinary tract infections (UTIs), the second most common type of infections worldwide. UTIs can lead to significant morbidity, especially in healthy females due to high rates of recurrence and antibiotic resistance. Strategies and therapeutic alternatives to antibiotics for prophylaxis and treatment against UTIs are continuously being sought after. Different to cranberry, which have been widely recommended in traditional medicine for UTIs prophylaxis, probiotics have emerged as a new alternative to the use of antibiotics against these infections and are the subject of new research in this area. Besides uropathogenic Escherichia coli (UPEC), the most common bacteria causing uncomplicated UTIs, other etiological agents, such as Klebsiellapneumoniae or Gram-positive bacteria of Enterococcus and Staphylococcus genera, seem to be more widespread than previously appreciated. Considerable current effort is also devoted to the still-unraveled mechanisms that are behind the UTI-protective effects of cranberry, probiotics and their new combined formulations. All these current topics in the understanding of the protective effects of cranberry against UTIs are reviewed in this paper. Further progresses expected in the coming years in these fields are also discussed.

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A randomized, double-blind, placebo-controlled pilot study to assess bacterial anti-adhesive activity in human urine following consumption of a cranberry supplement

Abstract: Urinary tract infections (UTIs) are one of the common bacterial infections treated with antibiotics.

Cited by 40 publications

References 48 publications

Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections

Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections

Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications

Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations

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