A Randomized Double-Blind Trial of Tinidazole Treatment of the Sexual Partners of Females With Bacterial Vaginosis

Vutyavanich, Teraporn; Pongsuthirak, Pallop; Vannareumol, Pensri; Ruangsri, Rung-Aroon; Luangsook, Praphan

doi:10.1097/00006250-199310000-00015

Cited by 26 publications

(25 citation statements)

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“…In general, women with BV have more sex partners and an earlier age of sexual debut than women without BV (62). Results of studies on the treatment of male sexual partners to reduce BV incidence and recurrence have been mixed (64)(65)(66)(67), which may be due to methodological issues, antibiotic dosing protocols, and limited sample size.…”

Section: Epidemiology Of Bvmentioning

confidence: 99%

Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective

2011

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Section: Epidemiology Of Bvmentioning

confidence: 99%

Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective

2011

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“…[277][278][279][280][281][282] species (infection with bacteriophages) in women was common, but that the rate of lactobacillus phage detection was higher in women with BV than without. 283,284 has good sensitivity and specificity for both treponemal (90·1-98·2% and 91·8-98·0%, 1399 respectively) and non-treponemal (80·6-98·2% and 89·4%, respectively) tests.…”

mentioning

confidence: 99%

Sexually transmitted infections: challenges ahead

Unemo

Bradshaw

Hocking

et al. 2017

The Lancet Infectious Diseases

587

469

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“…It is better tolerated than metronidazole 25,26 and very cheap (wholesale price per 2 g dose ≈ US$ 0.07). Studies of singlemdose tinidazole in women with BV have shown a wide range of effectiveness (51-97%) [27][28][29][30] but used different definitions of BV and cure. Experts now agree that the goal of BV treatment is symptomatic relief.…”

Section: Discussionmentioning

confidence: 99%

The syndromic management of vaginal discharge using only single-dose treatments: a randomized controlled trial in West Africa

Pépin

Sobela²,

Khonde³

et al. 2006

Bull World Health Organ

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Objective To evaluate whether single-dose treatments are as effective as standard therapy in the syndromic management of vaginal discharge. Methods A randomized controlled effectiveness trial compared single-dose tinidazole plus fluconazole (TF) with treatment for 7 days with metronidazole plus 3 days of treatment with vaginal clotrimazole (MC) among 1570 women presenting with vaginal discharge at primary health care institutions in Ghana, Guinea, Mali and Togo. Participants were randomly allocated to one of the two treatments by research nurses or physicians using precoded envelopes. Effectiveness was assessed by symptomatic response on day 14. Clinical identifier ClinicalTrials.gov NCT00313131. Findings The two treatment regimens had similar effectiveness: complete resolution was seen in 66% (TF) and 64% (MC) and partial resolution in 33% (TF) and 34% (MC) of participants (P = 0.26). Effectiveness was similar among subgroups with vulvovaginal candidiasis, Trichomonas vaginalis vaginitis or bacterial vaginosis. The two treatment regimens had a similar effectiveness among human immunodeficiency virus (HIV)-infected (TF: n = 76, 71% complete resolution, 28% partial; MC: n = 83, 72% complete resolution, 25% partial, P = 0.76) and HIV-uninfected women (TF: n = 517, 68% complete, 32% partial; MC: n = 466, 65% complete, 33% partial, P = 0.20). Cervical infections with Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium were uncommon among women not involved in sex work, were associated with bacterial vaginosis or T. vaginalis vaginitis, and did not alter response to treatment with agents active against vaginal infections. Four-fifths of women not relieved by a single dose of TF had a favourable response when MC was administered as second-line treatment. Conclusion Single-dose TF is as effective as multiple-dose MC in the syndromic management of vaginal discharge, even among women with HIV-infection. Given its low price and easier adherence, TF should be considered as a first-line treatment for vaginal discharge syndrome. Voir page 736 le résumé en français. En la página 736 figura un resumen en español.

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A Randomized Double-Blind Trial of Tinidazole Treatment of the Sexual Partners of Females With Bacterial Vaginosis

Cited by 26 publications

References 0 publications

Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective

Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective

Sexually transmitted infections: challenges ahead

The syndromic management of vaginal discharge using only single-dose treatments: a randomized controlled trial in West Africa

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