A randomized doubleblind comparison of fentanyl and sufentanil anaesthesia for coronary artery surgery

Thomson, Ian R.; Hudson, Robert J.; Rosenbloom, Morley; Meatherall, Robert

doi:10.1007/bf03015157

Cited by 17 publications

(2 citation statements)

References 15 publications

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“…Our association of the drugs used with outcomes must be examined. High dose fentanyl has been associated with better cardiac outcome as compared to other anesthetics (5,6,7) as well as renal outcome (8). A study of high dose fentany I (mean dose 62.4 !J.g/kg, range 50-89 IJ.g/kg) (9) showed minor hemodynamic changes (increased heart rate, arterial blood pressure, and systemic vascular resistance with noxious stimulation), but another study examining…”

Section: Drugs and Outcomesmentioning

confidence: 99%

The Efficacy and Safety of a Pharmacologic Protocol for Maintaining Coronary Artery Bypass Patients at a Higher Mean Arterial Pressure during Cardiopulmonary Bypass

Pirraglia,

Peterson,

Hartman

et al. 1998

J Extra Corpor Technol

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A recent randomized trial of higher versus lower mean arterial pressure (MAP) during cardiopulmonary bypass (CPB) showed that higher MAP on CPB was associated with a lower incidence of overall cardiac and neurologic morbidity and mortality in coronary artery bypass graft surgery (CABG) patients. Cardiopulmonary bypass MAP was controlled pharmacologically while CPB flow was held constant for any given period. The objective of the present study was to assess the efficacy and safety of this pharmacologic protocol. Two hundred forty-eight patients participated in the study; the mean age was 65.8 ± 9.4 years, 20% were women, and the mean preoperative ejection fraction was 48%. The low-flow conrrected CPB MAP attained for the low and high MAP groups was 56.7 ± 5.0 mmHg and 77.7 ± 7.1 mmHg, respectively (p = 0.0001). Major cardiac and neurologic outcomes, postoperative blood loss, renal dysfunction, intensive care unit (ICU) stay, and duration of intubation were not found to be significantly associated with any drug in the pharmacologic protocol. These findings support that the pharmacologic protocol used to maintain CABG patients at higher MAP on CPB is both efficacious and safe.

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Section: Drugs and Outcomesmentioning

confidence: 99%

The Efficacy and Safety of a Pharmacologic Protocol for Maintaining Coronary Artery Bypass Patients at a Higher Mean Arterial Pressure during Cardiopulmonary Bypass

Pirraglia,

Peterson,

Hartman

et al. 1998

J Extra Corpor Technol

View full text Add to dashboard Cite

show abstract

“…I These include patient-specific variables such as left ventricle function and preoperative beta-adrenergic blockade, and anaesthetic variables such as premedication, the specific opioid chosen, the use of intravenous sedative-hypnotic agents, and the muscle relaxant. [2][3][4][5][6][7] Temporally, the relaxant is the last of these variables to exert its haemodynamic effect. Thus, the haemodynamic response to a given relaxant will vary from patient to patient and from one anaesthetic or experimental protocol to another.…”

mentioning

confidence: 99%