A randomized placebo‐controlled trial of erythromycin for the treatment of Ureaplasma urealyticum to prevent premature delivery

Chronic lung disease of prematurity. The role of intra-uterine infection

“…Despite the evidence for the involvement of intra-uterine infection, antibiotics have, so far, failed to alter the natural history of preterm onset of labour [15], the inammatory response in the lungs or the risk of developing chronic lung disease [27]. It is likely that by birth the lung injury sequence has already started in babies exposed to intra-uterine infection.…”

“…These are all associated with an increased risk of preterm delivery and/or low birth weight, and the importance of the genital mycoplasmas is dicult to unravel from these confounding variables. Intervention studies, aiming to treat infection, have so far been disappointing in trying to prevent preterm delivery [15], but there is underway a multicentre study of the role of antibiotics in curtailing labour and early delivery (ORACLE) which aims to recruit 10,000 women in preterm labour.…”

Prophylactic antibiotics for the prevention of preterm birth in women at risk: A meta‐analysis

“…[22][23][24] For those evaluating the effect of abnormal vaginal flora, four used metronidazole, 9,11,16,19 six used clindamycin [12][13][14][15]17,20 and two used erythromycin. 10,18 For the three studies that principally assessed risk based on previous preterm delivery (with or without abnormal vaginal flora), one used metronidazole, 23 one used clindamycin 22 and one used a combination of metronidazole and erythromycin. 24 For the two studies assessing risk based on positive fetal fibronectin, one used metronidazole, 8 and the other a combination of metronidazole and erythromycin.…”

La surveillance microbiologique de la femme enceinte : quels examens réaliser durant la grossesse ?

“…Le simple portage étant fréquent au cours de la grossesse, il est difficile d'imputer formellement aux seuls mycoplasmes la responsabilité de ces complications (pour lesquelles on sait qu'il est souvent malaisé d'en déterminer la véritable étiologie). Plusieurs études, dont celle d'Eschenbach [16], ont montré qu'un traitement durant la grossesse de U. urealyticum par érythromycine ne diminuait pas le risque d'accouchement prématuré. Il faut également tenir compte de la très fréquente présence de mycoplasmes en cas de VB (situation où d'autres bactéries prolifèrent égale-ment, anaérobies en particulier).…”