A randomized study comparing triptorelin or expectant management following conservative laparoscopic surgery for symptomatic stage III–IV endometriosis

Loverro, Giuseppe; Carriero, Carmine; Rossi, A. Cristina; Putignano, G; Nicolardi, Vittorio; Selvaggi, Luigi

doi:10.1016/j.ejogrb.2006.10.034

Cited by 58 publications

(56 citation statements)

References 18 publications

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“…3,6 Dado que a endometriose afeta globalmente a vida da mulher, a avaliação da eficácia de um determinado tratamento baseada apenas em melhoria da dor e das taxas de fertilidade, apresenta-se como insuficiente. 7,8 Para além disso, é amplamente reconhecida a falta de correlação entre a intensidade dos sintomas e a gravidade e extensão das lesões. 9 Assim, a avaliação subjetiva pela doente da sua qualidade de vida é fulcral na abordagem da endometriose.…”

Section: Introductionunclassified

Validação da Versão Portuguesa do Questionário EHP-30 (The Endometriosis Health Profile-30)

Nogueira‐Silva

Costa

Martins³

et al. 2015

Acta Med Port

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Introduction:Endometriosis Health Profile Questionnaire-30 is currently the most used questionnaire for quality of life measurement in women with endometriosis. The aim of this study is to evaluate the psychometric properties and to validate the Portuguese Endometriosis Health Profile Questionnaire-30 version. Material and Methods: A sequential sample of 152 patients with endometriosis, followed in a Portugal reference center, were asked to complete a questionnaire on social and demographic features, the Portuguese version of the Endometriosis Health Profile Questionnaire-30 and of the Short Form Health Survey 36 Item -version 2. Appropriate statistical analysis was performed using descriptive statistics, factor analysis, internal consistency, item-total correlation and convergent validity. Results: Factorial analysis confirmed the validity of the five-dimension structure of the Endometriosis Health Profile Questionnaire-30 core questionnaire, which explained 83.2% of the total variance. All item-total correlations presented acceptable results and high internal consistency, with Cronbach's alpha ranging between 0.876 and 0.981 for the core questionnaire and between 0.863 and 0.951 for the modular questionnaire. Significant negative associations between similar scales of Endometriosis Health Profile Questionnaire-30 and Short Form Health Survey 36 Item -version 2 were demonstrated. Data completeness achieved was high for all dimensions. The emotional well-being scale in the core questionnaire and the infertility scale in the modular section had the highest median scores, and therefore the most negative impact on the quality of life of participating women. Discussion: The test-retest reliability and responsiveness of the questionnaire should be evaluated in future studies. Conclusion:The present study demonstrates that the Portuguese version of the Endometriosis Health Profile Questionnaire-30 is a valid, reliable and acceptable tool for evaluating the health-related quality of life of Portuguese women with endometriosis.

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Section: Introductionunclassified

Validação da Versão Portuguesa do Questionário EHP-30 (The Endometriosis Health Profile-30)

Nogueira‐Silva

Costa

Martins³

et al. 2015

Acta Med Port

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“…Four pregnancies were conceived using Intra-Uterine Insemination after ovarian induction in 4 women. The time to conception was 6.5 months (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Thirteen women in total tried IUI.…”

Section: Resultsmentioning

confidence: 99%

“…Benefit of this approach remains controversial [12]. A recent, randomized trial confirmed that the use of GnRH agonists does not improve fertility in grade III to IV endometrial lesions [13].…”

Section: Introductionmentioning

confidence: 99%

Outcome of Fertility after Radical Conservative Surgery in Grade III-IV Endometriosis Lesions: A Retrospective Analysis

Baekelandt¹,

Arne²,

Aelvoet³

et al. 2016

Int J Gynecol Clin Pract

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Purpose: Researching reproductive outcome after laparoscopic radical resection of grade III and IV endometrial lesions. Methods and Materials: A retrospective analysis of 54 women was carried out. The patients underwent laparoscopic radical resection in the Gynecology Department of a secondary health care center between January 2009 and December 2013. Diagnostic investigation, with histological confirmation of moderate to severe endometriosis, preceded surgical intervention in a multidisciplinary setting. Thirty seven of the 54 patients had an active desire for pregnancy. The outcome measure was the number of pregnancies in the subgroup of 37 women with an active desire for pregnancy. Results: Within the subgroup of 37 patients, 28 women became pregnant within the study period. Twelve patients became pregnant spontaneously and 16 had medically assisted pregnancies. Within the medically assisted group, 4 patients conceived after Intra-Uterine Insemination (IUI) and 12 after InVitro Fertilization (IVF). The pregnancy rate was 76%, a result similar to findings of earlier studies. Conclusion:The results of this retrospective analysis suggest that extensive laparoscopic surgery for moderate to severe endometriosis has a beneficial effect on fertility in both spontaneous and medically assisted pregnancies.

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“…Результаты нашего исследова-ния подтвердили преимущество использования дие-ногеста, а именно доля женщин, забеременевших после лечения эндометриоза, составила 64,6%, что сопоставимо с исследованиями, где в качестве гор-монотерапии после хирургического этапа применя-ли аГнРГ [27,28]. Должны быть выделены ограничения проведен-ного нами исследования.…”

Section: результатыunclassified

The combined approach (laparoscopy + dienogest) for endometrios-associated infertility treatment

Попов¹,

Fedorov²,

Manannikova³

et al. 2016

Probl. reprod.

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Эндометриоз является самым распространен-ным доброкачественным хроническим гинекологи-ческим заболеванием. Известно, что эндометриоз поражает около 10% женщин репродуктивного воз-раста и до 50% женщин, страдающих бесплодием [1]. Влияние эндометриоза на репродуктивную функ-цию женщин остается противоречивым с нескольки-ми предложенными механизмами, оказывающими негативное влияние на репродукцию [2]. Описаны две наиболее точные гипотезы, объясняющие эндо-e-mail: gyn_endoscopy@mail.ru метриозассоциированное бесплодие. Это прогресси-рующее интраперитонеальное воспаление и, как следствие, нарушение анатомических соотношений с формированием массивных спаек в малом тазу [3]. Другая гипотеза -снижение качества ооцитов, на-рушение маточно-трубного транспорта [4,5]. Основ-ной подход к лечению эндометриозассоциирован-ного бесплодия складывается из хирургического эта-па, гормонального лечения и экстракорпорального оплодотворения (ЭКО) или их комбинации [6]. Objective -to evaluate the feasibility of dienogest using after surgical excision of endometriotic focuses by counting the total number of coming pregnancies among the women with endometriosis-associated infertility. Material and methods. This retrospective study included 48 women with surgically confirmed endometriosis. Patients were divided into subgroups: the first group included 18 women with superficialis endometriosis, the second group consited of 23 women with endometriotic cysts, the third group had 7 women with deep infiltrating endometriosis. all patients were given dienogest 2 mg per day postoperatively within 6 months. Results. 31 (64,6%) patients became pregnant and 20 (41,7%) women achieved pregnancies by natural conception, in 5 (10,4%) cases pregnancy was obtained after IvF Conclusions. The combined approach (laparoscopy + dienogest) forendometrios-associated infertility treatment is effective among the patients with different stages of endometriosis (from superficial to infiltrative). Thus, 64.6% of women included in the study became pregnant after the treatment and 40% of women were delivered during the study period.

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A randomized study comparing triptorelin or expectant management following conservative laparoscopic surgery for symptomatic stage III–IV endometriosis

Cited by 58 publications

References 18 publications

Validação da Versão Portuguesa do Questionário EHP-30 (The Endometriosis Health Profile-30)

Validação da Versão Portuguesa do Questionário EHP-30 (The Endometriosis Health Profile-30)

Outcome of Fertility after Radical Conservative Surgery in Grade III-IV Endometriosis Lesions: A Retrospective Analysis

The combined approach (laparoscopy + dienogest) for endometrios-associated infertility treatment

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