A randomized trial comparing the efficacy of epinephrine with salbutamol in the treatment of acute bronchiolitis

Menon, Kusum; Sutcliffe, Teresa; Klassen, Terry P

doi:10.1016/s0022-3476(95)70234-2

Cited by 157 publications

(126 citation statements)

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“…Five trials evaluated the effects of adrenaline on bronchiolitis, 4,[17][18][19][20] and two on laryngotracheobronchitis. 10,11 Table 1 shows the characteristics of the seven clinical trials.…”

Section: Resultsmentioning

confidence: 99%

“…Higher incidence Canada (age between 6 and 3 ml, two doses in 30 minutes of pallor in the group of nebulization (1995) 19 12 months) admitted (n = 21). Nebulization with salbutamol with adrenaline, 30 minutes to hospital for (0.5%), 0.3 ml, diluted in 2.7 ml (47.6% versus 14.3%, p < 0.05) and acute bronchiolitis.…”

Section: Menon Et Al Patientsmentioning

confidence: 96%

“…Two of the five trials that used adrenaline doses greater than or equal to 3 ml 4,10,11,17,19 demonstrated a significant increase in heart rate. 17,4 In the first study, 99 children admitted for bronchiolitis were given three consecutive nebulizations with 4 ml of adrenaline (1:1000), at 4-hour intervals.…”

Section: The Effects Of Inhaled Adrenaline On Heart Ratementioning

confidence: 99%

“…4,19,18 In the first two the adrenaline dose was greater than or equal to 3 ml. Only one demonstrated a greater incidence of pallor in the adrenaline group (3 ml, two doses in 30 minutes), compared with the control group (salbutamol), at 30 minutes (47.6 versus 14.3%, p < 0.05) and 60 minutes (38.1 versus 14.3%, p = 0.06) after nebulization.…”

Section: Other Side Effects Of Inhaled Adrenalinementioning

confidence: 99%

“…Only one demonstrated a greater incidence of pallor in the adrenaline group (3 ml, two doses in 30 minutes), compared with the control group (salbutamol), at 30 minutes (47.6 versus 14.3%, p < 0.05) and 60 minutes (38.1 versus 14.3%, p = 0.06) after nebulization. 19 Fitzgerald et al described other adverse effects, such as a hyperactivity, vomiting, erythema, diarrhea, wheezing and epistaxis, in six patients in each treatment group (adrenaline 1:1000, 4 ml versus budesonide 0.05%, 4 ml). 11 …”

Section: Other Side Effects Of Inhaled Adrenalinementioning

confidence: 99%

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Segurança de nebulização com 3 a 5 ml de adrenalina (1:1000) em crianças: uma revisão baseada em evidência

Zhang¹,

Sanguebsche²

2005

J. Pediatr. (Rio J.)

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Suggested citation: Zhang L, Sanguebsche LS. The safety of nebulization with 3 to 5 ml of adrenaline (1:1000) in children: an evidence based review. J Pediatr (Rio J). 2005;81:193-7. AbstractObjective: To present the evidence regarding the safety of nebulization with 3-5 ml of adrenaline (1:1000) for the treatment of children with acute inflammatory airway obstruction.Sources of data: An electronic search was undertaken, using mainly Medline databases (January of 1949-July of 2004). The study inclusion criteria for this review were: 1) randomized clinical trial; 2) Patients (up to 12 yrs) with diagnosis of bronchiolitis or laryngotracheobronchitis; 3) use of adrenaline (1:1000) by nebulization. The principal data extracted from the trials included adrenaline dosages and their effects on heart rate and blood pressure and any other side effects.Summary of the findings: Seven clinical trials with a total of 238 patients were included for this review. Two of the five trials in which larger dosages (> 3 ml) of adrenaline were used demonstrated a significant increase in heart rate. The mean increase in heart rate varied from seven to 21 beats per minute, up to 60 minutes after treatment. The highest incidence of pallor was observed in one trial with 21 children treated by nebulization with 3 ml of adrenaline (47.6% in the adrenaline group vs. 14.3% in the salbutamol group, 30 minutes after treatment). Two clinical trials failed to observe a significant effect on blood pressure from nebulization with adrenaline (4 and 5 ml). Conclusion:Evidence shows that nebulization with 3 to 5 ml of adrenaline (1:1000) is a safe therapy, with minor side-effects, for children with acute inflammatory airway obstruction.J Pediatr (Rio J). 2005;81(3):193-7: Adrenaline, nebulization, laryngotracheobronchitis, bronchiolitis, side effects.

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