A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia

Hartman, Annelies; Winkel, M.L. te; Beek, Robert D. van; Keizer‐Schrama, Sabine M.P.F. de Muinck; Kemper, H.C.G.; Hop, Wim C. J.; Heuvel‐Eibrink, Marry M. van den; Pieters, Rob

doi:10.1002/pbc.21942

Cited by 148 publications

(200 citation statements)

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“…Twelve studies, [42][43][44][45][46][47][48][68][69][70][71][72] including two RCT 42,44 and seven high-quality studies [42][43][44][45][46]69,71 evaluated the effects of physical activity interventions on outcomes in children with pediatric cancer who did not undergo HSCT. One study of high quality 68 evaluated the effects of a single (30 min) exercise bout.…”

Section: Adultsmentioning

confidence: 99%

“…Despite improving fitness, interventions have not improved body composition. 42,70,72 As noted above, significant interest in the effects of exercise on blood markers exists for these patients. Marchese et al 69 reported no change in hemoglobin in ALL survivors (4-15 years) participating in aerobic and resistance training.…”

Section: Adultsmentioning

confidence: 99%

“…Liu et al 33 recently performed a systematic review on exercise interventions conducted in hematological cancer patients, including studies published up to September 2007. This area of research is growing considerably and several intervention studies in adult/children survivors of hematological cancer have been recently published in adults [34][35][36][37][38][39][40] and in children 28,[41][42][43][44][45][46][47] that were not included in the review by Liu et al 33 Here, we summarize the intervention data related to all the possible effects of physical activity on adult and pediatric hematological cancer survivors. The information is also detailed extensively in Supplementary Material.…”

Section: Introductionmentioning

confidence: 99%

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Exercise in adult and pediatric hematological cancer survivors: an intervention review

et al. 2010

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Observational research has shown that the physical activity levels of survivors of hematological cancer are low, with deleterious health consequences. This review summarizes the research on exercise interventions in adult and pediatric hematological cancer survivors. We searched MEDLINE, SPORTDiscus, CINAHL, Embase, Cochrane and PEDro through September 2009 for exercise intervention studies in children and adults with any type of hematological cancer. In the 24 adult intervention studies reviewed, we found strong evidence (that is, X3 high-quality studies and X75% reporting a significant benefit) for a benefit on body composition. Weak, but promising, evidence (X3 high-quality studies, but o75% reporting a significant benefit) was found for cardiorespiratory fitness, fatigue, muscle strength, physical functioning and quality of life. In pediatric interventions (13 studies), we found strong evidence for a benefit on muscle strength and cardiorespiratory fitness, particularly, if training was conducted in the hospital setting. Evidence is weak for ankle dorsiflexion, physical functioning and body composition. No exerciserelated risks were identified in adults or children studies. Though more randomized controlled trials are needed, a growing body of literature supports the notion that regular physical activity is safe and has potential benefits for both adult and pediatric hematological cancer survivors.

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Section: Adultsmentioning

confidence: 99%

Section: Adultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exercise in adult and pediatric hematological cancer survivors: an intervention review

et al. 2010

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“…2 This shows the value of physical exercise, although we realize that it is a challenge to design such interventions sufficiently that it can be maintained for the full period of ALL treatment. 17 In summary, it still remains to be determined whether the definition of "adiponcosis" may survive over time as a clinical relevant entity, but we fully agree that the underlying mechanisms of adiposity as a risk factor for pediatric haematologica 2015; 100:e432 …”

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confidence: 84%

Comment on "Acute lymphoblastic leukemia and adiponcosis" by M. Bifulco and AM Malfitano

2015

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Comment on "Acute lymphoblastic leukemia and adiponcosis" by M. Bifulco and AM MalfitanoWe read with interest the letter by Bifulco and Malfitano 1 that argues that adiposity may be an underlying cause of cancer, and of acute lymphoblastic leukemia (ALL) in particular. Based on our recently published paper "The negative impact of underweight and weight loss on survival of children with acute lymphoblastic leukemia" 2 and other studies, the authors suggest that the use of the entity "adiponcosis", derived from the fusion of "adiposis" and "oncosis", may be appropriate to support the hypothesis that adiposity increases the risk of ALL.Although we appreciate existing knowledge that high body mass index may in part enhance cancer risk (either by 'nature' or by 'nurture'), 3 this particular issue was not the focus of our study. As stated in a letter by Renehan,4 it is important to differentiate between studies examining the link between excess weight and incidence of cancer and those that examine being overweight and cancer survival. We examined the influence of being underweight on relapse risk and survival in children with ALL, and did not address the influence of weight on ALL risk. Most studies that Bifulco and Malfitano refer to in order to support their hypothesis of "adiponcosis" with respect to "ALL" addressed excess weight as an accelerator of ALL progression, rather than oncogenetic aspects of the question. [5][6][7][8][9][10] Nevertheless, there are many epidemiological studies that now show that excess weight is associated with increased risk for several common cancer types in adults, including breast cancer, cancer of the esophagus and ovaria. 3 These studies suggest that hormonal influences have a substantial influence; however, such studies have not yet been performed in children.In our Dutch national study, 2 including over 700 children, we have now analyzed the prevalence of being overweight and obese and compared this to healthy Dutch peers. The results show that the frequency of being overweight and obese [defined by a body mass index (BMI) of 20-25 kg/m 2 and >30 kg/m 2 , respectively] at diagnosis was 6% and 1%, respectively (Table 1). BMI data standardized for sex and age [BMI standard deviation score (SDS)] were available for 738 patients, of whom 104 (14%) were overweight (11%) and 3% obese (Table 2). By way of comparison, according to the standard normal distribution, 16% of the matched healthy Dutch population has a BMI over 1 SDS and 2% has a BMI over 2 SDS. These results did not show that being overweight and obesity are more prevalent in children with ALL in the diagnostic phase, hence our data do not support the hypothesis that overweight children have an increased risk of developing ALL.Although, epidemiological studies may give further insight into the existence of a link between adiposity and ALL, a direct causal relationship may be hard to show. We feel the suggested potential causative relationship of adiposity and ALL occurence, and consequently the true existence of the entity "ad...

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“…As a result, adult survivors of childhood cancer may suffer from cardiomyopathy, heart valve and conduction disorders [14,15], increased cardiovascular risk factors including hypertension, dyslipidemia [16][17][18], and obesity [19,20], pulmonary disorders [21,22], endocrine disorders [23] including hypothalamic-pituitary-adrenal disorders [24], diabetes mellitus [25], ovarian and Leydig cell dysfunction [26], and hypothyroidism [27]. Survivors of childhood cancer are also at increased risk for neurocognitive and neurosensory impairment including ocular degeneration, hearing loss and neuropathy [28][29][30][31], metabolic disturbances (abnormal blood counts, liver and kidney dysfunction, and osteoporosis) [28][29][30]32,33], transfusion-associated infections [30], and increased risk of subsequent neoplasm [14]. A major concern is that chronic LAE may increase in frequency and severity over time, and interact adversely with the normal ageing process, resulting in increasing and clinically significant impairment of vital organ systems during adulthood at a younger age than normal, and an increased risk of premature major illness or death [34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

The Role of Exercise in Pediatric and Adolescent Cancers: A Review of Assessments and Suggestions for Clinical Implementation

Klika

Tamburini

Galanti

et al. 2018

JFMK

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Abstract:In the European Union, five-year survival rates for childhood cancer patients are approaching 72-80%, which is a testament to better diagnostics and improved treatment. As a result, a large proportion of childhood cancer patients go on to live productive lives well past reproductive age. While this is encouraging, childhood cancer treatment is accompanied by multiple long-term adverse effects on physical and mental wellbeing. While there are several approaches to address mental health, reproductive integrity, secondary pathologies, and recurrence, in order to optimize quality of life in childhood cancer patients, exercise and nutrition should also be considered. It is clear that physical activity plays an important role in the prevention and reduction of long-term adverse side effects associated with cancer treatment in both children and adults. However, the current exercise guidelines for cancer survivors are based on adult data and accordingly are not appropriate for children. As children and adults are markedly different, including both the pathophysiology of cancer and exercise response, treatment plans incorporating exercise for children should be age-specific and individually tailored to both reduce the development of future comorbidities and enhance physical health. The purpose of this paper is to review the predominant cancer types and effects of cancer treatment in children, describe several special considerations, and propose a framework for assessment and exercise guidelines for this population.

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A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia

Cited by 148 publications

References 33 publications

Exercise in adult and pediatric hematological cancer survivors: an intervention review

Exercise in adult and pediatric hematological cancer survivors: an intervention review

Comment on "Acute lymphoblastic leukemia and adiponcosis" by M. Bifulco and AM Malfitano

The Role of Exercise in Pediatric and Adolescent Cancers: A Review of Assessments and Suggestions for Clinical Implementation

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