A Randomized Trial of Aspirin to Prevent Colorectal Adenomas

Baron, John A.; Cole, Bernard F.; Sandler, Robert S.; Haile, Robert W.; Ahnen, Dennis J.; Bresalier, Robert S.; McKeown‐Eyssen, Gail; Summers, Robert W.; Rothstein, Richard I.; Burke, Carol A.; Snover, Dale C.; Church, Timothy R.; Allen, John I.; Beach, Michael; Beck, Gerald J.; Bond, John H.; Byers, Tim; Greenberg, E. Robert; Mandel, Jack S.; Marcon, Norman E.; Mott, Leila A.; Pearson, Loretta H.; Saibil, Fred; Stolk, Rosalind U. van

doi:10.1056/nejmoa021735

Cited by 1,309 publications

(857 citation statements)

References 26 publications

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“…In contrast, COX-2 knock-out mice are more resistant to tumorigenesis in various organs (Oshima et al, 1996;Tiano et al, 2002;Howe et al, 2005). A number of clinical studies were performed for colorectal cancer prevention by administration of Nonsteroidal anti-inflammatory drugs (NSAIDs) or COX-2 inhibitors including sulindac, aspirin, celecoxib, rofecoxib (Giardiello et al, 1996;Steinbach et al, 2000;Giardiello et al, 2002;Baron et al, 2003;Higuchi et al, 2003;Sandler et al, 2003;Bertagnolli et al, 2006). These COX-2 inhibitors reduced adenoma only at a high dose but significantly increased mortality from cardiovascular complication.…”

Section: Discussionmentioning

confidence: 99%

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Mekhora

Muangnoi²,

Chingsuwanrote

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Mekhora

Muangnoi²,

Chingsuwanrote

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Numerous studies demonstrate that nonsteroidal anti-inflammatory drugs (NSAIDs) hold significant promise as anticancer therapeutics (10)(11)(12). Recent data on regular NSAID use indicated a reduction in the incidence of OC and inhibition of carcinogenesis (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

NSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo

et al. 2012

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Ovarian cancer (OC) is one of the most lethal gynaecological cancers, which usually has a poor prognosis due to late diagnosis. A large percentage of the OC cell population is in a nonproliferating and quiescent stage, which poses a barrier to success when using most chemotherapeutic agents. Recent studies have shown that several nonsteroidal anti‐inflammatory drugs (NSAIDs) are effective in the treatment of OC. Furthermore, we have previously described the molecular mechanisms of NSAIDs' induction of cancer apoptosis. In this report, we evaluated various structurally distinct NSAIDs for their efficacies in inducing apoptosis in nonproliferating OC cells. Although several NSAIDs‐induced apoptosis, Flufenamic Acid, Flurbiprofen, Finasteride, Celocoxib, and Ibuprofen were the most potent NSAIDs inducing apoptosis. A combination of these agents resulted in an enhanced effect. Furthermore, we demonstrate that the combination of Flurbiprofen, which targets nonproliferative cells, and Sulindac Sulfide, that affects proliferative cells, strongly reduced tumor growth when compared with a single agent treatment. Our data strongly support the hypothesis that drug treatment regimens that target nonproliferating and proliferating cells may have significant efficacy against OC. These results also provide a rationale for employing compounds or even chemically modified NSAIDs, which selectively and efficiently induce apoptosis in cells during different stages of the cell cycle, to design more potent anticancer drugs. © 2012 IUBMB IUBMB Life, 64(7): 636–643, 2012

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“…Undoubtedly, several recent clinical results validate the conceptual feasibility of cancer chemoprevention in humans. These findings bear out that nonsteroidal anti-inflammatory drugs such as aspirin (Baron et al, 2003) or selective inhibitors of cyclooxygenase-2 (COX-2) (Steinbach et al, 2000) interfere with colorectal malignancies, that selective oestrogen receptor modulators such as tamoxifen can prevent breast cancer (Fisher et al, 1998) and that the a-reductase inhibitor finasteride can delay the onset of prostate cancer (Thompson et al, 2003). However, chemopreventive interventions using drugs have raised safety concerns.…”

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confidence: 99%

Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis

et al. 2007

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Brown rice is a staple dietary constituent in Asia, whereas rice consumed in the Western world is generally white, obtained from brown rice by removal of the bran. We tested the hypothesis that rice bran interferes with development of tumours in TAg, TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) or Apc Min mice, genetic models of mammary, prostate and intestinal carcinogenesis, respectively. Mice received rice bran (30%) in AIN-93G diet throughout their post-weaning lifespan. In TAg and TRAMP mice, rice bran did not affect carcinoma development. In TRAMP or wild-type C57Bl6/J mice, dietary rice bran increased kidney weight by 18 and 20%, respectively. Consumption of rice bran reduced numbers of intestinal adenomas in Apc Min mice by 51% (Po0.01), compared to mice on control diet. In parallel, dietary rice bran decreased intestinal haemorrhage in these mice, as reflected by increased haematocrit. At 10% in the diet, rice bran did not significantly retard Apc Min adenoma development. Likewise, low-fibre rice bran (30% in the diet) did not affect intestinal carcinogenesis, suggesting that the fibrous constituents of the bran mediate chemopreventive efficacy. The results suggest that rice bran might be beneficially evaluated as a putative chemopreventive intervention in humans with intestinal polyps.

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A Randomized Trial of Aspirin to Prevent Colorectal Adenomas

Abstract: Low-dose aspirin has a moderate chemopreventive effect on adenomas in the large bowel.

Cited by 1,309 publications

References 26 publications

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

Eryngium foetidum Suppresses Inflammatory Mediators Produced by Macrophages

NSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo

Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis

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