A randomized trial of danazol pretreatment prior to endometrial resection

Safety and efficacy of manual syringe infusion of distending media for hysteroscopic procedures: a case–control study

“…In an attempt to decrease the incidence of dilutional hyponatremia or the systemic absorption of the distending media, various methods have been used [4], including automated fluid monitoring [5,6], intraoperative oxytocin or vasopressin use [7,8], pretreatment with danazol or gonadotropin-releasing hormone agonists [9,10], use of 1.5% glycine [11], or use of a bipolar resectoscope [12]. In order to minimize the amount of distending media infused during hysteroscopic procedures, we used the manual syringe infusion (MI) method to infuse distending media.…”

Pharmacologic Interventions to Minimize Fluid Absorption at the Time of Hysteroscopy

“…The effect of preoperative treatment with danazol for 4–6 weeks compared with a control group was evaluated by two studies (n=178), both by the same author. 26,27 Pooled analysis of one RCT and the other prospective cohort showed significant reduction in fluid absorption at the time of hysteroscopy (mean difference −175.7 mL, 95% CI −325.4 to −26.0, P <.05) (Fig. 3).…”

“…Preoperative pharmacologic treatment was assessed by 20 studies (one with three independent intervention and control arms), of which 11 examined the effect of a gonadotropin-releasing hormone (GnRH) agonist, [10][11][12][13][14][15][16][17][18][19][20] three assessed ulipristal acetate, 13,21,22 three assessed the effect of vasopressin, [23][24][25] two evaluated the use of danazol, 26,27 one evaluated letrozole, 13 and one evaluated the effect of oxytocin infusion. 28 A total of five studies compared the effect of different types of anesthesia on fluid absorption, such as local, general, and regional anesthesia.…”