A Rapid and Sensitive Method for the Detection of Aromatic Amines in Cosmetics

Abstract

Aromatic amines (AAs) are common chemical pollutants and banned ingredients in cosmetics. In this study, a rapid, simple and stable method for the detection of nine AAs in cosmetics was established based on the optimization of cation exchange solid-phase extraction and liquid chromatography tandem mass spectrometry. The method displayed good linearity within a range of 2-1,000 µg/kg, with limits of quantitation at the level of µg/kg for cosmetic samples. The recoveries obtained for all analyzed amines ranged between 83.6 and 97.8%, and the repeatability (r) and reproducibility (R) values indicated that all nine AAs showed good precision (r ≤ 4.5% and R ≤ 7.7%). The method was applied for the detection of 36 cosmetic samples. It was found that the primary pollutants of AAs were 3, 3'-dichlorobenzidine and 4-aminoazobenzene. The total amine concentration in cosmetic samples ranged from 880 to 5,200 µg/kg. The proposed method is applicable for the analysis of most cosmetic samples.

Tracking Aromatic Amines from Sources to Surface Waters

“…111 Consequently, there is a wide range of products found to have AA content, including kitchen utensils, 112 food contact materials, 113 herbicide formulations, 114 and cosmetics. 111 AAs are also metabolites of nitroarenes. For example, 1-nitropyrene, one of the major polycyclic aromatic compounds emitted in diesel exhaust, 115 is metabolized to 3aminobenzanthrone and 1-aminopyrene.…”

“…AAs are widely used in many other industrial processes, including the synthesis of pesticides, pharmaceuticals, and explosives. , They are also used in the production of epoxy resins, polyurethane, cosmetics, and food . Consequently, there is a wide range of products found to have AA content, including kitchen utensils, food contact materials, herbicide formulations, and cosmetics …”

“…23,72 They are also used in the production of epoxy resins, 72 polyurethane, 72 cosmetics, and food. 111 Consequently, there is a wide range of products found to have AA content, including kitchen utensils, 112 food contact materials, 113 herbicide formulations, 114 and cosmetics. 111 AAs are also metabolites of nitroarenes.…”

“… 111 Consequently, there is a wide range of products found to have AA content, including kitchen utensils, 112 food contact materials, 113 herbicide formulations, 114 and cosmetics. 111 …”