A rare case of a primary hepatic neuroendocrine tumor

Sethi, Sajiv; Kulkarni, Prasad

doi:10.21037/tgh.2016.06.07

Cited by 7 publications

(11 citation statements)

References 13 publications

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“…It is still challenging to distinguish between PHNETs and HCC, even with the assistance of these factors. Therefore, it is necessary to perform hematoxylin-eosin staining and immunohistochemistry for a definitive diagnosis[ 18 , 19 ]. PHNETs were usually misdiagnosed as HCCs or hepatic hemangiomas due to their uncharacteristic enhancement on CEUS and enhanced MRI and CT.…”

Section: Discussionmentioning

confidence: 99%

“…Surgery is preferred as the first-line treatment for patients with no metastases; it can improve the survival rate and bring greater benefit compared with conservative treatment[ 18 ]. The 5-year survival rate is as high as 74-78%[ 13 , 26 ], and surgery can even result in better outcomes for large tumors (27 cm × 13 cm)[ 27 ], but the recurrence rate is still high (19.8%)[ 13 ].…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics and outcome of primary hepatic neuroendocrine tumors after comprehensive therapy

Wang

Liu

Zhang

et al. 2020

WJGO

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BACKGROUND Primary hepatic neuroendocrine tumors (PHNETs), a group of neuroendocrine neoplasms, are extremely rare. There are only few case reports about PHNETs in the literature. The lack of large samples and multicenter research results in poor diagnostic and therapeutic approaches. AIM To discuss the clinical characteristics, diagnosis, and treatment of PHNETs and risk factors related to survival. METHODS We retrospectively analyzed the clinical data, imaging features, immunohistochemistry data, and treatment efficacy of 40 patients who were pathologically diagnosed with PHNETs and admitted to The First Affiliated Hospital of Zhengzhou University from January 1, 2014 to November 15, 2019. Finally, survival analysis was performed to identify the risk factors for survival. RESULTS The main symptoms and signs included intermittent abdominal pain (19 patients, 47.5%) and bloating (8 patients, 20.0%). The positive rates of tested tumor markers were recorded as follows: Carbohydrate antigen 19-9 (CA19-9) (6 patients, 15.0%), CA72-4 (3 patients, 7.5%), carcinoembryonic antigen (7 patients, 17.5%), and alpha-fetoprotein (6 patients, 15.0%). Immunohistochemical staining results showed positivity for Syn in 38 (97.4%) of 39 patients, for chromogranin A in 17 (65.4%) of 26 patients, for CD56 in 35 (94.6%) of 37 patients, for AE1/AE3 in 28 (87.5%) of 32 patients, and for Ki-67 in all 40 (100.0%) patients. The overall survival rate was significantly related to the tumor grade, AE1/AE3, and Ki-67. No significant correlation was found between other parameters (age, gender, tumor number, tumor size, metastasis, and treatment) and overall survival. CONCLUSION Higher grade, negative AE1/AE3, and higher Ki-67 are associated with a worse survival rate. Kinds of treatment and other parameters have no significant influence on overall survival.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and outcome of primary hepatic neuroendocrine tumors after comprehensive therapy

Wang

Liu

Zhang

et al. 2020

WJGO

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“…T he coronavirus disease 2019 (COVID-19) pandemic has resulted in a massive reorganization of hospital operations, with specific implications for patients hospitalized with gastrointestinal bleeding. 1,2 Guidelines recommend minimizing high-risk aerosol-generating procedures, including upper gastrointestinal endoscopy, and reducing direct patient contact by inpatient consultation services. [1][2][3] The impact of these changes on gastrointestinal bleeding, which is the most common gastrointestinal reason for hospitalization in the United States, 4 is unknown.…”

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confidence: 99%

“…This study examined the effect of the COVID-19 pandemic on outcomes for patients admitted for gastrointestinal bleeding at 2 affiliated hospitals in New York City, the epicenter of the COVID-19 pandemic during the study period. 2 We sought to assess differences in hospital length of stay for gastrointestinal bleeding before and during the COVID-19 pandemic. We also assessed differences in blood product transfusion requirements and the rate of endoscopy performed during hospitalization.…”

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confidence: 99%

Effect of the Coronavirus 2019 Pandemic on Outcomes for Patients Admitted With Gastrointestinal Bleeding in New York City

et al. 2020

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“…16 In fact, TACE has been reported to be an effective approach for the treatment of patients with extrahepatic NETs with intrahepatic metastasis. 12,14,17 For example, treatment of 20 patients with hepatic metastases by TACE led to a significant radiological response and symptom improvement in 90% of the patients. 15 In our current case, because the patient had multiple PHNETs in more than two lobes of the liver, surgical resection was not considered a safe option.…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic neuroendocrine tumor with multiple liver metastases: A case report with literature review

Xia

Zhang

et al. 2020

J Int Med Res

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Primary hepatic neuroendocrine tumors (PHNETs) are a group of extremely rare tumors that are difficult to differentiate from common hepatic malignancies on routine imaging studies. By presenting a case of PHNET, we herein introduce our experience with the diagnosis, differential diagnosis, and management of patients with this rare disease. The patient was preoperatively diagnosed with hepatic hydatidosis but postoperatively diagnosed with a PHNET with multiple liver metastases. He was successfully treated with transcatheter arterial chemoembolization. This case indicates that the clinical diagnosis of PHNET is a medical challenge. Although peptide receptor radionuclide therapy has been suggested as the mainstay of treatment for well-differentiated somatostatin receptor-positive PHNETs, patients with a large tumor burden may also benefit from transcatheter arterial chemoembolization.

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A rare case of a primary hepatic neuroendocrine tumor

Cited by 7 publications

References 13 publications

Clinical characteristics and outcome of primary hepatic neuroendocrine tumors after comprehensive therapy

Clinical characteristics and outcome of primary hepatic neuroendocrine tumors after comprehensive therapy

Effect of the Coronavirus 2019 Pandemic on Outcomes for Patients Admitted With Gastrointestinal Bleeding in New York City

Primary hepatic neuroendocrine tumor with multiple liver metastases: A case report with literature review

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