A Rare Case of an Inflammatory Myofibroblastic Tumor in a Middle-Aged Female

Kosma, L.; Khaldi, Lubna; Galani, Panagiota; Mytas, D.; Lafoyianni, Sofia

doi:10.1155/2012/148053

Cited by 9 publications

(13 citation statements)

References 11 publications

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“…Precise prognostic predictors are yet to be established. However surgical resectability with complete resection, tumour size and ALK expression [ 16 , 20 , 30 ] are variables that have been known to alter prognosis and disease evolution. Recurrence is known to be associated to site, size, age and incomplete resection [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Inoperable inflammatory myofibroblastic tumour of the para-nasal sinuses and orbit with recurrence responding to methotrexate and prednisolone: a case report

et al. 2015

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BackgroundInflammatory myofibroblastic tumour is a rare neoplasm with a potential to behave in a malignant manner. It can occur anywhere in the body, however involvement of the head, especially the para-nasal sinuses is rare.Case presentationA 33-year-old South Asian male presented with coryzal symptoms including a persistent cough with an asymmetrical swelling of the left side of the face. Imaging revealed a mass lesion involving the para-nasal sinuses eroding into the orbit. Histology and the clinical picture were compatible with inflammatory myofibroblastic tumour. As curative excision of the tumour was not feasible, medical management was offered. Despite early features of remission to glucocorticoids, tapering resulted in recurrence. Hence combination therapy with glucocorticoids and methotrexate was commenced with dramatic reduction of tumour burden and the patient has been in remission to date.ConclusionInflammatory myofibroblastic tumour has the potential to behave in a malignant manner. Medical management with chemotherapy, glucocorticoids and non-steroidal anti-inflammatory drugs though effective, do not have a uniform response pattern. Surgically unresectable inflammatory myofibroblastic tumour above neck should be treated aggressively with combination regimens. Combination of prednisolone with methotrexate has been shown to have good outcome.

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Section: Discussionmentioning

confidence: 99%

Inoperable inflammatory myofibroblastic tumour of the para-nasal sinuses and orbit with recurrence responding to methotrexate and prednisolone: a case report

et al. 2015

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“…Inflammatory myofibroblastic tumors (IMTs) are scarce mesenchymal solid tumors [ 1 ] with discrete immunohistochemistry and molecular attributes [ 2 ], which are not related to a particular location [ 3 ], but mostly involve the pulmonary tract [ 4 ]. There are different reports about the essence of these tumors as benign to possibly malignant [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…There are different reports about the essence of these tumors as benign to possibly malignant [ 4 , 5 ]. IMT may impact any age and sex [ 1 , 2 ]. It may develop in organs such as the liver [ 6 ], stomach, small intestine, large intestine, mediastinum, retroperitoneum, and bladder [ 5 , 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumors in a Case with Hypogastric Discomfort

et al. 2017

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Patient: Male, 68Final Diagnosis: Inflammatory myofibroblastic tumorSymptoms: 2–3 kg weight loss • Helicobacter pylori positive which were eradicated after treatment course • hypogastric region discomfort • no association between the pain, defecation and eating • no history of HIV, diabetes, smoking and alcohol consumption was recorded • no symptoms of nausea, vomiting, fever and shaking chills • normal vital signs • tenderness in the right lower quadrant of the abdomen with no rebound state was notedMedication: —Clinical Procedure: Lab examinationt-imaging-colonoscopy-surgerySpecialty: Gastroenterology and HepatologyObjective:Rare diseaseBackground:Inflammatory myofibroblastic tumors (IMTs) are scarce tumors with discrete immunohistochemical and molecular attributes which are not related to a particular location. There are different reports about the intrinsic nature of these tumors as benign to possibly malignant.Case Report:Here we report the case of a 68-year-old man referred to the Internal Medicine Department of Razi Hospital in Rasht (a city in the north of Iran) due to right lower quadrant (RLQ) discomfort with no specific symptoms. Colonoscopy revealed a mass-like lesion. Polymorphonuclear cells (PMNCs) admixed by some eosinophils were demonstrated histopathologically. Immunohistochemical evaluation was positive for vimentin, CD34, smooth muscle actin, and ALK, and negative for CD117 and desmin. The tumor was successfully removed by surgery with no chemotherapy. No recurrence was reported.Conclusions:We have performed surgical excision of the mass with no chemotherapy and no recurrence. Although recurrence is reported to be low, we recommend long-term follow-up after surgery.

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“…l tumor inflamatorio miofibroblástico (TIM) o pseudotumor inflamatorio es una enfermedad poco frecuente, de etiología desconocida, caracterizada por lesiones tumorales en diversos órganos y tejidos blandos 1 . La ubicación más frecuentemente descrita es la pulmonar, siendo la abdominal poco común.…”

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“…La histología se caracteriza por la presencia de miofibroblastos y células inflamatorias 1,5,6 . Se ha discutido si su origen es neoplásico o naturaleza post inflamatoria.…”

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Tumor inflamatorio miofibroblástico peritoneal. Respuesta favorable asociada a infliximab: Caso clínico

et al. 2015

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Myofibroblastic tumor (MIT) is characterized by the infiltration of different organs, most commonly the lungs, with nodular lesions composed of myofibroblasts and inflammatory cells, which can be identified by specific patterns in the immunohistochemical studies. When it involves the peritoneum it is difficult to eradicate, tends to relapse and it has an invasive behavior, requiring its differentiation from peritoneal carcinomatosis. Treatment may be surgical excision, the use of non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids. We report a 30 years old female with an unremarkable medical history, presenting with abdominal pain and progressive abdominal distention. A CT scan revealed multiple peritoneal nodular lesions. A surgical biopsy was reported as a myofibroblast and inflammatory cell infiltrate. Immunohistochemical staining was consistent with MIT. Given the extensive involvement of the peritoneum surgical therapy was not considered appropriate and treatment with NSAID and glucocorticoids was started. No response was observed after 6 months, therefore infliximab therapy was started. After 10 months of follow-up the patient is well, returned to normal life, ascites improved and resolved and CT scan showed partial regression or stabilization of the lesions.

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A Rare Case of an Inflammatory Myofibroblastic Tumor in a Middle-Aged Female

Cited by 9 publications

References 11 publications

Inoperable inflammatory myofibroblastic tumour of the para-nasal sinuses and orbit with recurrence responding to methotrexate and prednisolone: a case report

Inoperable inflammatory myofibroblastic tumour of the para-nasal sinuses and orbit with recurrence responding to methotrexate and prednisolone: a case report

Inflammatory Myofibroblastic Tumors in a Case with Hypogastric Discomfort

Tumor inflamatorio miofibroblástico peritoneal. Respuesta favorable asociada a infliximab: Caso clínico

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