A Rare Case of Bowel Obstruction due to Metastatic Breast Cancer

Sharbatji, Mohamad; Khalid, Sameen; Wazir, Mohammed; Majeed, Umair; Jain, Akriti G

doi:10.14309/crj.0000000000000144

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…Bolzacchini et al reported 96 cases over a 45-year period [2]. Additionally, among reported cases, it is not uncommon to find these intestinal deposits in patients with prior documented spread to other organs or background carcinomatosis [1,4,5]. However, in our patient, metastasis was first detected in the bowel, which added to the diagnostic dilemma.…”

Section: Discussionmentioning

confidence: 59%

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Atypical Presentation of Breast Cancer Metastasis to the Bowel: A Case Report

Ayeni,

Elemile,

Nwadiokwu

et al. 2024

Cureus

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Breast cancer rarely metastasizes to the intestinal tract. It is even more uncommon to find intestinal metastasis as the first sign of distant spread. We describe an atypical case of small and large bowel carcinomas arising from primary breast cancer and presenting as the first evidence of distant metastasis. Clinicians should therefore consider the possibility of gastrointestinal (GI) metastasis when patients with breast cancer present with GI symptoms.

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Section: Discussionmentioning

confidence: 59%

“…Radiological findings are often non-specific, and many patients are diagnosed at surgery, during which a palliative surgical intervention may be offered with little or no benefit. There have been some reported benefits with chemotherapy and/or hormonal therapy [1,5]. However, our patient was unfit to receive either.…”

Section: Discussionmentioning

confidence: 79%

Atypical Presentation of Breast Cancer Metastasis to the Bowel: A Case Report

Ayeni,

Elemile,

Nwadiokwu

et al. 2024

Cureus

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“…12 In the current series, 22 patients were diagnosed with gastrointestinal metastasis after the initial diagnosis of breast carcinoma from July 2002 to October 2018 in Tianjin Medical University Cancer Institute and Hospital. Information on the most prominent subgroup of breast carcinoma patients with gastrointestinal metastases is still limited to case reports 5,13 and small series. 14 The current series of 22 patients is the largest study of Chinese women to our knowledge.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Features and Prognosis of Gastrointestinal Metastases From Breast Carcinoma: A Clinicopathological Study of 22 Patients

Wang

et al. 2023

Int J Surg Pathol

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Background. Breast carcinoma is the most common malignancy in women. Gastrointestinal metastasis is rarely found or diagnosed in patients with breast cancer. Methods. Clinicopathological features, treatment options, and prognosis were evaluated retrospectively for 22 patients with gastrointestinal metastases of breast carcinoma in Chinese women. Results. Presenting symptoms were non-specific: anorexia (21/22), epigastric pain (10/22), and vomiting (8/22), and 2 patients (2/22) presented with nonfatal hemorrhage. The first sites of metastases were skeleton (9/22), stomach (7/22), colorectal (7/22), lung (3/22), peritoneal (3/22), and liver (1/22). ER, PR, GATA binding protein 3 (GATA3), gross cystic disease fluid protein-15 (GCDFP-15), and keratin 7 can effectively confirm the diagnosis, especially in the case of keratin 20 negativity. Histology showed mainly ductal breast carcinoma (n = 11) was the predominant source of gastrointestinal metastases in this study, and lobular breast cancer (n = 9) accounted for a considerable proportion. The disease control rate to systemic therapy was 81% (17 of 21 treated patients), and the objective response rate was 10% (2 of 21 treated patients). Median overall survival was 71.5 months (range, 22-226 months), median survival for distant metastases was 23.5 months (range, 2-119 months) and the median survival for the time of gastrointestinal metastases diagnosis was 6 months (range, 2-73 months). Conclusions. Performing the endoscopy with biopsy was crucial for patients with any subtle gastrointestinal symptoms and a history of breast cancer. It is important to distinguish primary gastrointestinal carcinoma from breast metastatic carcinoma in order to select the optimal initial treatment and avoid unnecessary surgery.

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“…Finally, there were approximately 32 cases of gastrointestinal metastases of breast carcer. [ 11 – 42 ] The patient's information was summarized in Table 1 and the clinicopathological features were analyzed in Table 2 . The mean age of the patients with gastrointestinal metastases was 62.75 years (range: 39–84).…”

Section: Discussionmentioning

confidence: 99%

Widespread Metastasis to the Stomach 10 Years After Primary Breast Cancer

Fu¹,

Zou²,

Long-Li³

et al. 2020

Medicine

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Rationale: Breast cancer is a common malignant tumor. The most common metastatic sites of breast cancer are the bone, brain, liver and lung, and gastrointestinal metastases are rare. Considering that the median time interval from the initial breast cancer diagnosis to stomach metastasis is 77.5 months, gastrointestinal metastases are rarely observed 10 years after primary breast cancer. Patient concerns: Here, we present a 63-year-old female with unusual endoscopy results that revealed scattered polyps and mucosal infiltration throughout the stomach, which were later confirmed to be metastatic lobular carcinoma of the breast that had been surgically removed 10 years earlier. Diagnosis: The patient was diagnosed with gastric metastases of breast cancer by immunohistochemistry. Interventions: The patient underwent endocrine therapy with palbociclib and tamoxifen. Outcomes: After 1 year of endocrine therapy, the symptoms of upper abdominal discomfort and fatigue were relieved and a new gastroscopy revealed there had been no significant progression of the gastric metastasis. According to the Response Evaluation Criteria in Solid Tumors (RECIST), the patient reached a state of stable disease. Lessons: Gastric metastases of breast cancer are rare in the clinical setting. However, considering the possibility of gastric metastases from breast cancer and performing an upper endoscopy are crucial for patients who present with any subtle gastric symptoms and have a past medical history of breast cancer, even if the breast cancer occurred more than 10 years ago.

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A Rare Case of Bowel Obstruction due to Metastatic Breast Cancer

Cited by 6 publications

References 10 publications

Atypical Presentation of Breast Cancer Metastasis to the Bowel: A Case Report

Atypical Presentation of Breast Cancer Metastasis to the Bowel: A Case Report

Clinicopathological Features and Prognosis of Gastrointestinal Metastases From Breast Carcinoma: A Clinicopathological Study of 22 Patients

Widespread Metastasis to the Stomach 10 Years After Primary Breast Cancer

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