A rare case of cellulitis‐like cutaneous metastasis of gastric adenocarcinoma

Takata, Tsutomu; Takahashi, Aya; Tarutani, Masahito; Sano, Shigetoshi

doi:10.1111/j.1365-4632.2012.05498.x

Cited by 9 publications

(7 citation statements)

References 10 publications

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“…However, the To the best of our knowledge, there are few case reports on cutaneous lymphangiosis carcinomatosa in patients with gastric cancer. 3,4 Importantly, cutaneous metastases can be the first manifestation of an internal tumor and must always be considered when erysipelas-like skin changes occur in patients with solid tumors and/or when antibiotic treatment is not efficient. A skin biopsy is mandatory.…”

Section: Cutaneous Lymphangiosis Carcinomatosa Of Gastric Cancer Trig...mentioning

confidence: 99%

Cutaneous lymphangiosis carcinomatosa of gastric cancer triggered by herpes zoster

et al. 2022

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Section: Cutaneous Lymphangiosis Carcinomatosa Of Gastric Cancer Trig...mentioning

confidence: 99%

Cutaneous lymphangiosis carcinomatosa of gastric cancer triggered by herpes zoster

et al. 2022

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“…Cutaneous metastases may be the first presentation of such malignancies, or occur during follow-up. 1 , 2 They usually manifest as solitary or multiple red or violaceous dermal or subcutaneous painless nodules, and may also appear as cellulitis-like or erysipelas-like erythematous plaques. 2 - 4…”

Section: Disscusionmentioning

confidence: 99%

“…According to literature review, we found that tumors from gastric origin are distinguished by the expression of some adenoepithelial and/or gastrointestinal markers including Ckpan (AE1/AE3), CK7, CK8/18, CK19, CEA, CDX-2 or EMA, which were all positive in our case ( Table1 ). 1 , 2 , 5 - 10 The clinical history is usually helpful. Therefore, we diagnosed this patient with cutaneous metastases from gastric adenocarcinoma.…”

Section: Disscusionmentioning

confidence: 99%

Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy

Liu

Yan

Zhang

et al. 2015

An. Bras. Dermatol.

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We report the case of a 38-year-old man, who developed cutaneous metastases in the left inguinal groove 15 years after curative gastrectomy for advanced gastric adenocarcinoma. Histopathologic examination revealed poorly differentiated adenocarcinoma cells. They were stained positive for villin, CDX-2, CKpan (AE1/ AE3), CEA, CK8/18, CK19, CK7, EMA, Ki-67 (50%), and negative for S-100, CK20, CD34, GCDFP-15 and TTF-1. The patient underwent local excision, after the presence of other metastases was excluded. Nevertheless, local recurrence developed at the surgical bed one year later and PET/CT revealed metastases to lymph nodes, bone and skin. He died 2 years after the appearance of cutaneous metastases. We have reviewed the literature and described the immunohistochemical characteristics of cutaneous metastases from gastric adenocarcinoma.

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“…The nature of the clear cells has been related to an enlarged defective melanosome formation, rather than to a lipoidal degeneration of melanocytes or glycogen, which is usually observed in other clear cell tumors of the skin. 4 Ballooning changes have been described in both primary and metastatic lesions. 5 The exact mechanism of these ballooning changes is as yet unknown.…”

mentioning

confidence: 99%

“…The most common clinical manifestation of metastatic gastric carcinoma is nonspecific firm nodules. However, diagnosis could be difficult if skin metastases are displayed in a form similar to those in other skin diseases, such as carcinoma erysipelatoides, allergic contact dermatitis‐like patterns, carcinoma en cuirasse , alopecia neoplastica, and neurofibroma‐like patterns . To our knowledge, no instances of metastatic gastric carcinoma showing an unusual presentation similar to that of radiation recall dermatitis have been reported.…”

mentioning

confidence: 99%

Metastatic gastric signet ring cell carcinoma clinically mimicking radiation recall dermatitis

et al. 2014

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A 53-year-old woman presented to the dermatology clinic with a history of a bilateral circular orange discoloration around the upper and lower eyelids. On physical examination, the orange flat plaque lesions involved both the upper and lower eyelids, resembling a pair of circles. The lesions of the medial side of both of the upper eyelids were particularly large (Fig. 1a,b). There was orange discoloration of the palms (Fig. 1c) and soles. The sclerae and oral mucosa appeared normal. She had no organomegaly. We learned that the patient ate too much carrot and orange over the last two months, which underlined her anamnesis. In the light of the clinical exam and anamnesis, the patient was diagnosed xanthelasmas and carotenoderma. Laboratory tests were evaluated, and the total cholesterol, high-density lipoprotein cholesterol, and triglyceride levels were 258 mg/dl (range 50-200 mg/dl), 35.2 mg/dl (range 35-55 mg/dl), and 137 mg/dl (0-150 mg/dl). Respectively, the total cholesterol level was in the higher than normal range.Xanthelasma is the most common type of cutaneous xanthoma. They may indicate hyperlipidemia, but 25-70% of patients in most cases are normolipidemic. Histologically, foamy histiocytes occur in the perivascular area, mostly in the middle and superficial layers of the dermis. They contain membrane-bound lipid vacuoles, cholesterol crystals, lysosomes, and residual bodies. 1 Carotenoderma is a phenomenon characterized by orange pigmentation of the skin, resulting from carotene deposition mainly in the stratum corneum, in sweat and in sebum, such as the nasolabial folds, palms, and soles. The sclerae are not affected, and this helps to distinguish carotenoderma from jaundice. 2 Both diseases are distinct clinical manifestations. Carotene exclusively accumulates in the regions such as thick stratum corneum, where the proportion of sebum is high. 2 In this case, the orange ring occurred due to the accumulation of carotene in xanthelasma lesions, where the amount of lipid is rather high.

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A rare case of cellulitis‐like cutaneous metastasis of gastric adenocarcinoma

Cited by 9 publications

References 10 publications

Cutaneous lymphangiosis carcinomatosa of gastric cancer triggered by herpes zoster

Cutaneous lymphangiosis carcinomatosa of gastric cancer triggered by herpes zoster

Cutaneous metastases from gastric adenocarcinoma 15 years after curative gastrectomy

Metastatic gastric signet ring cell carcinoma clinically mimicking radiation recall dermatitis

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