A rare case of cutaneous basal cell carcinosarcoma in an immunosuppressed patient

Davis, Kyle; Whale, Karen; Tran, Sonia; Hamilton, Sam; Kandamany, Nanda

doi:10.1016/j.pathol.2019.10.011

Cited by 2 publications

(1 citation statement)

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“…Despite only 54 reported cases in the literature, the actual incidence might be higher due to underreporting, discrepancies in tissue processing, and variable histological appearances [ 33 ]. A BCCS predominantly occurs in sun-exposed skin areas and mainly affects elderly men [ 34 ]. Clinically, these tumors can present as new, rapidly forming masses or as pre-existing lesions that show sudden rapid growth.…”

Section: Discussionmentioning

confidence: 99%

The Rarity in the Rarity: Presentation of Three Cases of Cutaneous Carcinosarcoma with Clinical and Histopathological Insights

Cazzato,

Colagrande,

Caputo

et al. 2024

Dermatopathology

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A cutaneous carcinosarcoma (cCS) is a rare and aggressive skin cancer characterized by both carcinomatous (epithelial) and sarcomatous (mesenchymal) components, making it a biphasic tumor. Despite its occurrence in various organs, a cCS is exceptionally rare in the skin, predominantly affecting older males. The etiology of a cCS is unclear, but it may originate from a single progenitor cell capable of dual differentiation or from a collision of carcinoma and sarcoma cells. Clinically, a cCS presents as a rapidly growing, painful, ulcerated nodule or plaque on sun-exposed skin, with a high risk of local invasion and metastasis. Histopathologically, a cCS includes various epithelial components, such as squamous cell carcinoma and basal cell carcinoma, along with undifferentiated sarcomatous components resembling atypical fibroxanthoma. The tumor may also exhibit heterologous differentiation like angiosarcomatous or rhabdomyosarcomatous features. We present three cases of a cCS, highlighting their clinical and histological characteristics and comparing them with previously reported cases. Understanding a cCS is complicated by its rarity and diverse presentation, emphasizing the need for further research to elucidate its pathogenesis and optimal management.

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Section: Discussionmentioning

confidence: 99%