A Rare Case of Fungal Burn Wound Infection Caused by <i>Fusarium solani</i> in Vietnam

Tram, Que Anh; Minh, Nguyen Thai; Anh, Do Ngoc; Lam, N N; Dung, Tran Ngoc; Chau, Ngo Thi Minh; Le, Tran-Anh

doi:10.1177/2324709620912122

Cited by 7 publications

(9 citation statements)

References 18 publications

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“…Among them, 28 case series and 15 irrelevant studies were excluded. Finally, 36 case reports encompassing 44 burn patients were included for the final analysis 10–45 …”

Section: Resultsmentioning

confidence: 99%

“…In 36 of the 44 cases, fungal infections were initially suspected and identified from the burn wound samples 10–27,31–33,35–37,39–45 . In the remaining 8 cases, presentations of fungal wound infection were not observed, whereas invasive fungal infections were found in other sites such as blood, arterial thrombosis, teeth, feces, urine, sputum, and tracheal fluid 28–30,34,38 …”

Section: Resultsmentioning

confidence: 99%

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Fungal Infection in Burn Patents

Lineaweaver

Breland

2021

Ann Plast Surg

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Objectives The aims of this study were to review recent fungal infection case reports published, evaluate the treatment regimens and clinical outcomes, and provide recommendations for future management. Methods A review of case reports published over the last decade was conducted. PubMed was searched to collect the relevant citations using a combination of the key words (“burn,” “burned,” “burns,” “fungal,” “fungi,” and “fungus”) in title or abstract. Case series, reviews, guidelines, and experimental and non-English studies were excluded. Statistical analyses were performed using Microsoft Excel 2019. Results A total of 36 case reports encompassing a total of 44 burn patients with fungal infection were included in the final analysis. Ablative surgeries, including surgical excision, debridement, skin graft, vitrectomy, teeth extraction, valve replacement, or amputation, were performed in 38 cases after the suspicion or identification of fungal infection. Twenty-nine of them were eventually discharged, yielding a survival rate of 76.3%. In the remaining 6 cases, ablative surgery was not mentioned and 3 of them eventually died, yielding a survival rate of 50%. The total mortality was 27.27%. Among the 12 death cases, 1 was infected with Candida albicans, 1 with non-albicans Candida, 2 with Aspergillus spp, 2 with Fusarium spp, 4 with Zygomycetes, and 2 with other fungal species. Conclusions The overall mortality of fungal wound infection is still high in burn patients around the world, especially those infected with non-Candida species. Early diagnosis of fungal infection, early initiation of appropriate antifungal therapy, and effective surgical intervention are key measures to improve the treatment effect and reduce the mortality of fungal infection in burn patients.

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“…Among them, 28 case series and 15 irrelevant studies were excluded. Finally, 36 case reports encompassing 44 burn patients were included for the final analysis 10–45 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Fungal Infection in Burn Patents

Lineaweaver

Breland

2021

Ann Plast Surg

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“…In this study, the most common fungus isolated from wounds was Fusarium . As a plant pathogen, Fusarium widely exists in natural environments, particularly in soil [ 25 ]. However, a study in Vietnam reported that humans could also be infected by the fungus through burn injuries.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and Early Bacteriology of Extremely Severe Burns from an LPG Tanker Explosion in Eastern China

Jin

Min

Weng

et al. 2022

J Epidemiol Glob Health

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The incidence of liquefied petroleum gas (LPG)-related accidents in China has increased over the recent years. In addition, infection remains a big challenge in cases of severe burns. Therefore, the present study aimed to provide valuable information for a better control of infections in the event of such disasters. In this study, a total of 16 patients who suffered extremely severe burns after an LPG tanker explosion were included. Thereafter, bacteriological culture results were collected within a week. Of 16 patients, 13 (81.25%) were male and the average age of all patients was 60.63 years. In addition, the mean burned area was 83.03% TBSA. Additionally, a total of 553 organism cultures were conducted out of which 287 isolates (51.90%) showed positive results. Notably, 38.52% were Gram-negative bacteria, 7.59% were Gram-positive bacteria and 5.79% were fungi. Moreover, the most prevalent Gram-negative bacteria were Stenotrophomonas maltophilia (28.97%) followed by Acinetobacter baumannii (28.53%), and Klebsiella pneumoniae (14.02%). On the other hand, the three most predominant Gram-positive bacteria were Enterococcus faecalis (33.33%), Staphylococcus aureus (28.89%) and Staphylococcus sciuri (17.78%). Furthermore, the most common fungi included Candida (38.24%), Fusarium (20.59%) and Aspergillus fumigatus (14.71%). With regard to the bacterial resistance patterns, carbapenem-resistant organisms included Acinetobacter baumannii (97.80%), Pseudomonas aeruginosa (67.57%), and Klebsiella pneumoniae (75.56%). In addition, Staphylococcus sciuri, Staphylococcus epidermidis, and Staphylococcus haemolyticus were identified to be methicillin-resistant. This study revealed that there was a high incidence of infection in victims of severe burns as a result of mass burn accidents, accompanied by early fungal infection.

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“…FSSC, F. solani species complex (SC); FFSC, F. fujikuroi SC; FOSC, F. oxysporum SC; FNSC, F. nisikadoi SC; FIESC, F. incarnatum-equiseti SC; FDSC, F. dimerum SC; FCSC, F. chlamydosporum SC. 10.3389/fmicb.2022.992582 Frontiers in Microbiology 08 frontiersin.org 2006; Pai et al, 2010;Atty et al, 2014;Rosanova et al, 2016;Karadag et al, 2020;Tram et al, 2020;Liza et al, 2021). We observed 63.2% (24/38) of isolates from skin secretions belonged to FSSC.…”

Section: Discussionmentioning

confidence: 99%

“…Severe burns and poorly controlled diabetes are thought to be high risk factors for invasive mold infections ( Nucci and Anaissie, 2007 ; Enoch et al, 2017 ). However, little is known about the epidemiology of Fusarium strains causing locally invasive skin infection in patients with burns or diabetes mellitus, limited by sporadic case reports ( Nucci and Anaissie, 2002 ; Taj-Aldeen et al, 2006 ; Pai et al, 2010 ; Atty et al, 2014 ; Rosanova et al, 2016 ; Karadag et al, 2020 ; Tram et al, 2020 ; Liza et al, 2021 ). We observed 63.2% (24/38) of isolates from skin secretions belonged to FSSC.…”

Section: Discussionmentioning

confidence: 99%

Comparison of molecular and MALDI-TOF MS identification and antifungal susceptibility of clinical Fusarium isolates in Southern China

et al. 2022

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BackgroundFusarium species are opportunistic causative agents of superficial and disseminated human infections. Fast and accurate identification and targeted antifungal therapy give help to improve the patients’ prognosis.ObjectivesThis study aimed to evaluate the effectiveness of matrix-assisted laser desorption ionisation time of flight mass spectrometry (MALDI-TOF MS) for Fusarium identification, and investigate the epidemiology and antifungal susceptibility profiles of clinical Fusarium isolates in Southern China.MethodsThere were 95 clinical Fusarium isolates identified by DNA sequencing of translation elongation factor 1-alpha (TEF1α) and MALDI-TOF MS, respectively. Antifungal susceptibility testing of isolates was performed by broth microdilution according to the CLSI approved standard M38-A3 document.ResultsSeven species complexes (SC) with 17 Fusarium species were identified. The most prevalent SC was the F. solani SC (70.5%, 67/95), followed by the F. fujikuroi SC (16.8%, 16/95). F. keratoplasticum within the F. solani SC was the most prevalent species (32.6%, 31/95). There were 91.6% (87/95) of isolates identified by MALDI-TOF MS at the SC level. In most of species, amphotericin B and voriconazole showed lower MICs compared to itraconazole and terbinafine. The F. solani SC showed higher MICs to these antifungal agents compared to the other SCs. There were 10.5% (10/95) of strains with high MICs for amphotericin B (≥8 μg/ml), terbinafine (≥32 μg/ml) and itraconazole (≥32 μg/ml) simultaneously, mostly focusing on F. keratoplasticum (9/10).ConclusionMALDI-TOF MS exhibited good performance on the identification of Fusarium strains at the SC level. The F. solani SC was the most prevalent clinical SC in Southern China. The MICs varied significantly among different species or SCs to different antifungal agents.

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A Rare Case of Fungal Burn Wound Infection Caused by Fusarium solani in Vietnam

Cited by 7 publications

References 18 publications

Fungal Infection in Burn Patents

Fungal Infection in Burn Patents

Epidemiology and Early Bacteriology of Extremely Severe Burns from an LPG Tanker Explosion in Eastern China

Comparison of molecular and MALDI-TOF MS identification and antifungal susceptibility of clinical Fusarium isolates in Southern China

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