A patient with extensive burn injuries was admitted to the National Hospital of Burns in Hanoi, Vietnam, and diagnosed with fungal wound infection by histological examination of skin biopsy samples. Fusarium solani was isolated and identified by analysis of its morphological features and the sequence of the internal transcribed spacer region. The isolation showed in vitro resistant to fluconazole, voriconazole, itraconazole, amphotericin B, and caspofungin. Invasive fusariosis is difficult to treat due to its angioinvasive property and its lacking amenability to treatment with antifungal drugs. This infection is rare and has not been reported so far in Vietnam.

Background: In-hospital mortality after emergency coronary artery bypass grafting (CABG) remains an important issue that has needed considerable attention in recent years as the mortality rate is still high and prevention factors are not yet optimal. Our study presents the first largest cohort of emergency CABG from one large institution in Vietnam with the primary aim of comparing a large variety of pre-, intra-and postoperative parameters between in-hospital mortality patients and in-hospital survival patients and investigate risk factors of in-hospital mortality in patients undergoing emergency CABG. Methods: We conducted a retrospective evaluation of prospectively collected data in patients undergoing emergency CABG at the Hanoi Heart Hospital (Hanoi, Vietnam) from January 1, 2017, to December 31, 2019. Primary outcome variable was in-hospital mortality. Results: A total of 71 patients were included in final analysis. The mean age of the cohort was 68.68 years (± 9.28, range 38-86). The mean weight, height and body mass index were 54.35 kg (± 9.17, range 37-77), 158.96 (±7.64, range 145-179) and 21.48 kg/m 2 (±3.08, range 13.59-30.08), respectively. In-hospital mortality rate was 9.86%. Preoperative risk factors for in-hospital mortality included diabetes, decreased ejection fraction (EF), EF below 30%, cardiogenic shock, elevated systolic pulmonary artery pressure (PAP), elevated NT-ProBNP, and Euroscore II. Without grafting with left internal thoracic artery, and prolonged cardiopulmonary bypass (CPB) time were increased intraoperative factors for inhospital mortality risk. In-hospital mortality's postoperative risk factors were found to be postextubation respiratory failure requiring mechanical ventilation, ventricular fibrillation, dialysis-requiring acute renal failure, pneumonia, bacterial sepsis, gastrointestinal bleeding, and prolonged mechanical ventilation time. Significant predictors determining in-hospital mortality were known as prolonged CPB time in surgery and postoperative ventricular fibrillation. Conclusion:Our hospital mortality rate after emergency CABG was relatively high. An optimal preventive strategy in emergency CABG management should target significant factors combined with other previously identified risk factors to reduce in-hospital mortality.

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Astronauts are always faced with serious health problems during prolonged spaceflights. Previous studies have shown that weightlessness significantly affects the physiological function of female astronauts, including a change in reproductive hormones and ovarian cells, such as granulosa and theca cells. However, the effects of microgravity on these cells have not been well characterized, especially in granulosa cells. This study aimed to investigate the effects of simulated microgravity (SMG) on the proliferation and morphology of porcine granulosa cells (pGCs). pGC proliferation from the SMG group was inhibited, demonstrated by the reduced O.D. value and cell density in the WST-1 assay and cell number counting. SMG-induced pGCs exhibited an increased ratio of cells in the G0/G1 phase and a decreased ratio of cells in the S and G2/M phase. Western blot analysis indicated a down-regulation of cyclin D1, cyclin-dependent kinase 4 (cdk4), and cyclin-dependent kinase 6 (cdk6), leading to the prevention of the G1-S transition and inducing the arrest phase. pGCs under the SMG condition showed an increase in nuclear area. This caused a reduction in nuclear shape value in pGCs under the SMG condition. SMG-induced pGCs exhibited different morphologies, including fibroblast-like shape, rhomboid shape, and pebble-like shape. These results revealed that SMG inhibited proliferation and induced morphological changes in pGCs.

Mục tiêu: Đáng giá các tiêu chí lựa chọn bệnh trong phẫu thuật thay van động mạch chủ ít xâm lấn qua đường mở ngực trước phải dựa trên hình ảnh chụp cắt lớp vi tính (CT). Đối tượng và phương pháp: Thu thập hình ảnh CT động mạch chủ (ĐMC) của 14 bệnh nhân được phẫu thuật thay van ĐMC qua đường mở ngực trước phải tại Bệnh viện Tim Hà Nội từ tháng 10 năm 2019 đến tháng 6 năm 2020. Phân tích một số đặc điểm hình ảnh liên quan tới kỹ thuật mổ và 3 tiêu chí của nhóm tác giả Glauber M và cộng sự. Kết quả: Tỷ lệ ĐMC lệch phải là 2/14 (14,3%), khoảng cách từ ĐMC đến xương ức không quá 10 cm đạt 4/14 (28,6%), độ nghiêng của ĐMC lên lớn hơn 45­­0 chiếm 7/14 (50%); không có bệnh nhân nào đạt được cả 3 tiêu chí này. Đa phần (12/14 - 85,7%) van ĐMC được nhìn trực diện (vuông góc) từ khoang gian sườn II, và 100% vị trí kẹp ĐMC thông thường nằm ngang mức khoang gian sườn II và III. Kết luận: Tiêu chí lựa chọn bệnh nhân dựa trên hình ảnh chụp CT của Glauber M và cộng sự trong AVR-RAT có tính ứng dụng trong thực hành điều trị không cao, chỉ mang tính chất tham khảo. Đường mổ qua khoang gian sườn II, có thể mở rộng xuống khoang gian sườn III, là hợp lý ở hầu hết các trường hợp AVR-RAT.