A rare case of liposarcoma of the spermatic cord

Dunev, V.R.; Genov, P.; Georgiev, М.; Stoykov, B.A.; Kolev, Nikola

doi:10.1016/j.eucr.2020.101336

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…The fat cells are separated by either loose myxoid stroma or fibrous stroma that shows atypical cells with large hyperchromatic nuclei. This is in comparison with the case report of Dunev et al (19) According to histopathologic analysis, the tumor mass was made up of dedifferentiated and well-differentiated liposarcoma, as well as nests of big, poorly differentiated lipoblasts that protruded from the myxoid, sclerosing, or welldifferentiated liposarcoma. There were no pathogenic alterations in the spermatic cord or testis.…”

Section: Discussionsupporting

confidence: 77%

Liposarcoma of Spermatic Cord: A Case Report

Hamed¹,

Khalaf²,

Allam³

et al. 2023

The Egyptian Journal of Hospital Medicine

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A painless inguinal or scrotal tumor is a characteristic of the uncommon illness known as liposarcoma of the spermatic cord (LSC). We introduce a 40-year-old man who was hospitalized to the Surgery Department with indications of a right inguinal unilateral, painless, hard, firm mass that was slow-growing. Histopathology evaluation revealed a lipomatous neoplasm formed of lobules of fat cells of variable size having large nuclei with few showing nuclear indentation by vacules. The fat cells are separated by either loose myxoid stroma or fibrous stroma that shows atypical cells with large hyperchromatic nuclei. The mass is surrounded by an intact facia. The submitted membranes and fibrofatty tissues are free from tumor invasion.

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Section: Discussionsupporting

confidence: 77%

Liposarcoma of Spermatic Cord: A Case Report

Hamed¹,

Khalaf²,

Allam³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…Nevertheless, there are no pathognomonic features that can unequivocally distinguish benign from malignant masses. MRI serves as an indispensable modality, providing crucial data for accurate tumor localization and delineation of its anatomical extension 15 .…”

Section: Discussionmentioning

confidence: 99%

Recurrent paratesticular liposarcoma : a case report

Blaiech,

Ben Othmen,

Ouahchi

et al. 2024

Annals of Medicine &Amp; Surgery

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Introduction and importance: Paratesticular liposarcoma is a rare condition, with fewer than 200 cases reported worldwide. It is a malignant tumor that originates from fat tissue with high risk of recurrence. Herein, we present a contralateral recurrence of a treated paratesticular liposarcoma. To our best knowledge, in the current literature, there is few cases reported with recurrent paratesticular liposarcoma. Case presentation: We report the case of a 62-year-old who presented with a rapidly growing painless right hemiscrotal swelling. Clinical and radiographic evidence suggested the presence of two paratesticular tumors. The patient underwent a radical orchidectomy with resection of the two tumors through an inguinal approach. The histologic examination revealed a sclerosing, well-differentiated liposarcoma. The decision of the multidisciplinary consultation meeting was not to do adjuvant treatment. A follow up of 12 months showed recurrence of the contralateral scrotum revealed by an FDG-PET/scan. Clinical discussion: Paratesticular liposarcoma, a rare spermatic cord tumor, affects adults aged 50-60, often presenting with scrotal swelling. Diagnosis involves ultrasound, computed tomography and magnetic resonance imaging. Surgical intervention, including radical orchiectomy and adjuvant radiotherapy, is common for management, while the role of chemotherapy is inconclusive. High-grade subtypes carry a higher recurrence risk. Conclusion: Paratesticular liposarcoma, is often misdiagnosed preoperatively. it is typically managed through radical orchidectomy, which includes wide excision and high ligation to ensure free surgical margins and avoid recurrence. The role of adjuvant therapy remains debatable. Despite a generally favorable prognosis, long-term follow-up is crucial because of the elevated risk of recurrence.

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“…[5] The total disease-specific survival at 5 and 10 years in cases of spermatic cord sarcoma is 75% and 55%. [23]…”

Section: Discussionmentioning

confidence: 99%

Rare paratesticular localization of dedifferentiated liposarcoma: Case report and review of the literature

et al. 2023

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Rationale: Dedifferentiated liposarcoma is defined as a malignant tumor that changes its shape from a well-differentiated liposarcoma to a non-liposarcomatous form. Most paratesticular liposarcomas manifest as an inguinal, painless, slow-growing mass. The standard treatment is extensive surgical excision, radiotherapy being proposed for cases with positive margins, those with recurrence, or in cases of the existence of unfavorable prognostic factors. Patient concerns: We present the case of a young patient diagnosed initially with left hydrocele, which after 2 years proved to mask a differentiated liposarcoma of the spermatic cord. The initial clinical manifestations were represented by the increase in volume of the left groin-scrotal region and pain at this level. Diagnosis: Microscopic examination in hematoxylin-eosin staining highlighted the presence of lipoblasts and fibroblasts in association with areas of hemorrhage and tumor necrosis. The performed immunohistochemical tests confirmed the diagnosis of dedifferentiated liposarcoma. To support and confirm the presence of the mouse double minute 2 homolog gene mutation, chromogenic in situ hybridization analysis was performed. Interventions: The initial treatment was the surgical one. After 2 weeks, the patient received zolendronic acid for hypercalcemia which was caused by the osseous metastasis. Outcomes: The patient died secondary to acute renal failure caused by hypercalcemia despite the treatment received. Lessons: This case underlines the importance of both the correct management of oncological patients, as well as immunohistochemical and genetic tests in the identification of prognostic factors, with the ultimate goal of administering an appropriate oncological treatment.

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A rare case of liposarcoma of the spermatic cord

Cited by 5 publications

References 5 publications

Liposarcoma of Spermatic Cord: A Case Report

Liposarcoma of Spermatic Cord: A Case Report

Recurrent paratesticular liposarcoma : a case report

Rare paratesticular localization of dedifferentiated liposarcoma: Case report and review of the literature

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