A rare case of necrotizing fasciitis caused by Vibrio cholerae O8 in an immunocompetent patient

Dobrović, Karolina; Rudman, Franjo; Ottaviani, Donatella; Crnek, Sandra Šestan; Leoni, Francesca; Škrlin, Jasenka

doi:10.1007/s00508-016-1060-3

Cited by 11 publications

(8 citation statements)

References 12 publications

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“…Sixteen cases of necrotizing fasciitis caused by NOVC have been previously reported (Table 2) [9][10][11][12][13][14][15][16][17]. The majority of patients were exposed to seawater or had an injury.…”

Section: Discussionmentioning

confidence: 99%

Intensive care management of a patient with necrotizing fasciitis due to non-O1/O139 Vibrio cholerae after traveling to Taiwan: a case report

et al. 2020

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Background: Vibrio cholerae are oxidase-positive bacteria that are classified into various serotypes based on the O surface antigen. V. cholerae serotypes are divided into two main groups: the O1 and O139 group and the non-O1/ non-O139 group. O1 and O139 V. cholerae are related to cholera infection, whereas non-O1/non-O139 V. cholerae (NOVC) can cause cholera-like diarrhea. A PubMed search revealed that only 16 cases of necrotizing fasciitis caused by NOVC have been recorded in the scientific literature to date. We report the case of a Japanese woman who developed necrotizing fasciitis caused by NOVC after traveling to Taiwan and returning to Japan. Case presentation: A 63-year-old woman visited our hospital because she had experienced left knee pain for the past 3 days. She had a history of colon cancer (Stage IV: T3N3 M1a) and had received chemotherapy. She had visited Taiwan 5 days previously, where she had received a massage. She was diagnosed with septic shock owing to necrotizing fasciitis. She underwent fasciotomy and received intensive care. She recovered from the septic shock; however, after 3 weeks, she required an above-knee amputation for necrosis and infection. Her condition improved, and she was discharged after 22 weeks in the hospital. Conclusions: With the increase in tourism, it is important for clinicians to check patients' travel history. Clinicians should be alert to the possibility of necrotizing fasciitis in patients with risk factors. Necrotizing fasciitis caused by NOVC is severe and requires early fasciotomy and debridement followed by intensive postoperative care.

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Section: Discussionmentioning

confidence: 99%

Intensive care management of a patient with necrotizing fasciitis due to non-O1/O139 Vibrio cholerae after traveling to Taiwan: a case report

et al. 2020

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“…NOVC bacteremia is strongly related to exposure to coastal or estuarine water or consumption of seafood, particularly oysters. 22,23 Many NOVC stains have been isolated in the coastal waters of countries such as Germany, India, South Korea, and France. [24][25][26][27] Our review found that 47.8% of patients (11/23) had a possible source of infection; 6 cases were attributed to consuming seafood and 4 to contaminated water.…”

Section: Mode Of Transmissionmentioning

confidence: 99%

“…29,30 Furthermore, several new virulence gene variants were reported in some environmental NOVC strains. 23 2018 A study suggested that NOVC can release outer membrane vesicles that induce miR-146a to induce colonization. 31 T3SS has also been demonstrated to facilitate colonization 32 and enhance the virulence of NOVC isolates.…”

Section: Pathogenesismentioning

confidence: 99%

<p>Non-O1, Non-O139 <em>Vibrio cholerae</em> (NOVC) Bacteremia: Case Report and Literature Review, 2015–2019</p>

Zhang¹,

Lu²,

Qian³

et al. 2020

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Non-O1, non-O139 Vibrio cholerae (NOVC) does not agglutinate with O1 and O139 antisera and can cause intestinal and extraintestinal infections in immunocompromised individuals. NOVC bacteremia has the highest mortality among NOVC infections, and the number of reports has increased in recent years. Nevertheless, some clinicians are poorly informed about this disease. Herein, we describe a documented case of NOVC bacteremia in a male patient with impaired liver function. Blood cultures revealed the presence of V. cholerae, but this strain showed self-coagulation on the serum agglutination test. To our knowledge, this phenomenon is unreported among cases of NOVC infections. This pathogen was finally confirmed as NOVC via PCR. Because the patient worked as a garbage transporter, he was likely infected after contact with contaminated water through a foot wound. The patient developed septic shock shortly after admission and ultimately died from the illness. This paper reviews 23 cases of NOVC bacteremia from 2015 to 2019. To improve the accuracy of identifying NOVC and analyze its virulence factors, relevant detection methods were reviewed and analyzed.

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“…Especially in Northern Europe (Baltic Sea), infections of swimmers have been predominantly caused by V. cholerae nonO1/nonO139 (Baker-Austin et al 2016b). Some serious infections of swimmers due to V. cholerae nonO1/nonO139 have also been reported from other European countries (Stypulkowska-Misiurewicz et al 2006;Huhulescu et al 2007;Sterk et al 2015;Dobrovic et al 2016;Engel et al 2016;Hirk et al 2016;Maraki et al 2016). The observed increase in infection frequency has been linked to global warming and the significantly increased water temperatures observed in many aquatic environments (Baker-Austin et al 2016b;Vezzulli et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Application of three different methods to determine the prevalence, the abundance and the environmental drivers of culturableVibrio choleraein fresh and brackish bathing waters

et al. 2018

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AimsThree cultivation methods were used to study the prevalence and abundance of Vibrio cholerae in Eastern Austrian bathing waters and to elucidate the main factors controlling their distribution.Methods and Results Vibrio cholerae abundance was monitored at 36 inland bathing sites with membrane filtration (MF), a standard most probable number (MPN) approach and direct plating (DP). Membrane filtration yielded the most reliable and sensitive results and allowed V. cholerae detection at 22 sites with concentrations up to 39 000 CFU per 100 ml, all belonging to serogroups other than O1 and O139 and not coding for cholera toxin and toxin coregulated pilus. Direct plating turned out as an easy method for environments with high V. cholerae abundances, conductivity was the only significant predictor of V. cholerae abundance in the bathing waters at warm water temperatures.Conclusions Vibrio cholerae nonO1/nonO139 are widely prevalent in Eastern Austrian bathing waters. Instead of the standard MPN approach, MF and DP are recommended for V. cholerae monitoring. Conductivity can be used as a first easy‐to‐measure parameter to identify potential bathing waters at risk.Significance and Impact of the Study Vibrio cholerae nonO1/nonO139 infections associated with bathing activities are an increasing public health issue in many countries of the northern hemisphere. However, there are only limited data available on the prevalence and abundance of V. cholerae in coastal and inland bathing waters. For monitoring V. cholerae prevalence and abundance, reliable and simple quantification methods are needed. Moreover, prediction of V. cholerae abundance from environmental parameters would be a helpful tool for risk assessment. This study identified the best culture‐based quantification methods and a first quick surrogate parameter to attain these aims.

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A rare case of necrotizing fasciitis caused by Vibrio cholerae O8 in an immunocompetent patient

Cited by 11 publications

References 12 publications

Intensive care management of a patient with necrotizing fasciitis due to non-O1/O139 Vibrio cholerae after traveling to Taiwan: a case report

Intensive care management of a patient with necrotizing fasciitis due to non-O1/O139 Vibrio cholerae after traveling to Taiwan: a case report

<p>Non-O1, Non-O139 <em>Vibrio cholerae</em> (NOVC) Bacteremia: Case Report and Literature Review, 2015–2019</p>

Application of three different methods to determine the prevalence, the abundance and the environmental drivers of culturableVibrio choleraein fresh and brackish bathing waters

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