A rare case of non-Hodgkin lymphoma in a pacemaker pocket

Moruzzo, Daniela; Bindi, Massimo; Bongiorni, Maria Grazia; Castiglioni, Maido

doi:10.1080/10428190903039990

Cited by 11 publications

(26 citation statements)

References 7 publications

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“…The authors also failed to state any signs of infection, either as positive blood culture or as a positive microbiological smear of the pacemaker pocket. The same can be said for the case reported by Moruzzo and colleagues, 5 who described an NHL following chronic inflammation of a pacemaker pocket. They also failed to mention any microbiological proof of infection.…”

Section: Discussionsupporting

confidence: 66%

B-Cell lymphoma at the site of pacemaker generator

Keyser

Schopka

Stadlbauer

et al. 2020

HeartRhythm Case Reports

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Section: Discussionsupporting

confidence: 66%

B-Cell lymphoma at the site of pacemaker generator

Keyser

Schopka

Stadlbauer

et al. 2020

HeartRhythm Case Reports

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“…Recent studies have expanded the correlation between lymphomas and implantable devices beyond breast prostheses. Lymphomas have been linked to a range of devices, including cardiac, joint, gluteal, testicular, and intraocular implants, made from both silicone and non-silicone materials ( Moruzzo et al, 2009 ; Palraj et al, 2010 ; Sanchez-Gonzalez et al, 2013 ; Kellogg et al, 2014 ; Vivacqua et al, 2015 ). Although genetic predisposition plays a role, it is evident that implants themselves can influence the inflammatory response in the body.…”

Section: Discussionmentioning

confidence: 99%

Breast implant surface topography triggers a chronic-like inflammatory response

Vinci,

Belgiovine,

Janszen

et al. 2024

Life Sci. Alliance

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Breast implants are extensively employed for both reconstructive and esthetic purposes. However, the safety of breast implants with textured surfaces has been questioned, owing to a potential correlation with anaplastic large-cell lymphoma and the recurrence of breast cancer. This study investigates the immune response elicited by different prosthetic surfaces, focusing on the comparison between macrotextured and microtextured breast implants. Through the analysis of intraoperatively harvested periprosthetic fluids and cell culture experiments on surface replicas, we demonstrate that macrotextured surfaces elicit a more pronounced chronic-like activation of leucocytes and an increased release of inflammatory cytokines, in contrast to microtextured surfaces. In addition, in vitro fluorescent imaging of leucocytes revealed an accumulation of lymphocytes within the cavities of the macrotextured surfaces, indicating that the physical entrapment of these cells may contribute to their activation. These findings suggest that the topography of implant surfaces plays a significant role in promoting a chronic-like inflammatory environment, which could be a contributing factor in the development of lymphomas associated with a wide range of implantable devices.

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“…Of the 22 selected studies, 6 were carried out in the United States of America (USA): Hamaker et al [24]; Herrmann, Mishra, and Greenway [25]; Magilligan and Isshak [26]; Moseley et al [19]; Reyes [27]; and Zarifi et al [28]. Fourteen were carried out in Europe: 1 in Portugal [29], 2 in Spain [30,31], 2 in the United Kingdom [32,33], 1 in Norway [34], 2 in Italy [35,36], 1 in Germany [37], 1 in Greece [38], 1 in Austria [39], 1 in Slovakia [40], 1 in the Netherlands [41], and 1 in Switzerland [42]. On the Asian continent, two studies were carried out in Japan [43] and one in Israel [44].…”

Section: Study Featuresmentioning

confidence: 99%

“…Figure 2. Risk of bias among case reports [24][25][26][27][28][29][30][31][32][34][35][36][37][39][40][41][42][43].…”

Section: Risk Of Bias In Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Malignant Neoplasms Arising in the Cardiac Pacemaker Cavity: A Systematic Review

Moraes,

Dal Moro,

Pessoa

et al. 2023

Cancers

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Cancer is the abnormal proliferation of physiologically inadequate cells. Studies have identified the cardiac pacemaker pocket as a site of rare neoplasms. To evaluate the clinical outcomes, treatment, prognosis, and individualized management of tumors originating in the cardiac pacemaker pocket, a systematic review was conducted using case reports and case series available in the PubMed/Medline, Science Direct, Cochrane Central, LILACS, and Scientific Electronic Library Online (Scielo) databases. Pacemaker pocket tumors affected patients with a mean age of 72.9 years, with a higher incidence in males (76.9%, n = 10). The average time for neoplasm development was 4.4 years (54.07 months). The most prevalent model was Medtronic (38.4%, n = 5), with titanium (83.3%) being the most common metal composition. Chemotherapy was the most performed procedure among patients (38.4%), followed by radiation therapy (38.4%) and surgical tumor resection (30.7%). Six analyzed cases (46.1%) resulted in death, and four patients (30.7%) achieved a cure. Patients with pacemakers should be routinely evaluated for the occurrence of malignant tumors at the site of device implantation.

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A rare case of non-Hodgkin lymphoma in a pacemaker pocket

Cited by 11 publications

References 7 publications

B-Cell lymphoma at the site of pacemaker generator

B-Cell lymphoma at the site of pacemaker generator

Breast implant surface topography triggers a chronic-like inflammatory response

Malignant Neoplasms Arising in the Cardiac Pacemaker Cavity: A Systematic Review

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