A Rare Case of Perirenal Myelolipoma: Diagnostic Approach and Therapeutic Strategy

D’Addessi, Alessandro; Racioppi, Marco; Fanasca, Angelo; Zannoni, Gian Franco; Alcini, E

doi:10.3109/00365599709030668

Cited by 4 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increased incidence of myelolipomas has been noted at autopsy in patients with chronic debilitating diseases such as cancer or burn victims [1,40,41]. It has also been associated with other chronic debilitating diseases such as coronary artery disease, obesity, diabetes mellitus, and other endocrinopathies (including long-term exogenous steroid use), all of which were present in our patient [14,18,32].…”

Section: Figure 4bmentioning

confidence: 53%

“…These generally occur in the retroperitoneal space, and in particular in the presacral space, although cases of myelolipomas in the liver, stomach, and thoracic cavity have also been reported [3,4,5,6,7,8,9,10,11,12,13]. Perirenal, extra-adrenal myelolipomas have also been reported, with a total of 16 published cases in the English literature [2,14,15,16,17,18,19,20,21,22,23,24]. Only one of these tumors appears to originate in the renal sinus [23].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Rare Case of an Extra-Adrenal Myelolipoma Arising in the Renal Sinus: A Case Report and Review of the Literature

Clark

Farver

Ulchaker

et al. 2005

The Scientific World JOURNAL

View full text Add to dashboard Cite

Section: Figure 4bmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

A Rare Case of an Extra-Adrenal Myelolipoma Arising in the Renal Sinus: A Case Report and Review of the Literature

Clark

Farver

Ulchaker

et al. 2005

The Scientific World JOURNAL

View full text Add to dashboard Cite

“…With respect to adrenal located myelolipomas, 86.2% were unilateral, 9.35% bilateral; 71.4% were located on the right side, and 28.6% on the left side. Rarely, myelolipomas can appear in the lungs, 21,22 parietal pleura, 23 mediastinum, 24 -27 liver, 28,29 and in the perirenal 30 and presacral [31][32][33][34][35][36][37][38] regions.…”

Section: Analysis Of Cases Reported In the Literaturementioning

confidence: 99%

Two Siblings With Untreated CYP21 Deficiency and Giant Myelolipomas

Rodríguez-Vallejo

Gómez-Pérez²

2006

The Endocrinologist

View full text Add to dashboard Cite

The authors present the case histories of 2 siblings with the virilizing form of congenital adrenal hyperplasia (CYP21 deficiency). The diagnosis was established during the neonatal period; however, glucocorticoid therapy was inconsistent. At the age of 30, the first case presented with pain in the right upper quadrant. An ultrasound scan disclosed a large mass occupying the greater part of the abdominal cavity. On computed tomography, this mass showed characteristics compatible with myelolipoma. The diagnosis was confirmed by pathologic examination. Interestingly, the sister of this patient, who was asymptomatic, was found to have similar tumors on both adrenal glands by ultrasound examination. The pathologic examination of these tumors confirmed the diagnosis of myelolipoma. The precise mechanism of myelolipoma development is not known. Prolonged ACTH stimulation could be a contributing factor. Both patients are now being treated with glucocorticoids. A review of the literature is presented. Learning Objectives• Appraise competing explanations of how myelolipomas may develop in patients with CYP21 deficiency, the virilizing form of congenital adrenal hyperplasia. • Relate the clinical and imaging features of myelolipoma as noted in a literature review of more than 200 patients, as well as possible complications and associated disorders. • List treatment options for myelolipoma and suggest ways of choosing between them. CASE REPORTS Case 1T his case report presents a 31-year-old Mexican woman with virilizing CYP21 hydroxylase deficiency. Shortly after birth, she had corrective surgery for ambiguous genitalia. She was treated with prednisone between 2 and 14 years of age. One year before admission, she developed a dull pain in the left upper quadrant associated with dyspepsia. On examination, she had a body mass index (BMI) of 36 kg/m 2 and a blood pressure of 120/70 mm Hg. Acanthosis nigricans and skin tags on the neck and axillae were prominent. A tender abdominal mass was identified in the left upper quadrant. A computed tomography (CT) scan (Fig. 1A) confirmed the presence of a large mass apparently attached to the left adrenal gland.

show abstract

Paratracheal Extramedullary Hematopoiesis

et al. 2001

View full text Add to dashboard Cite

Extramedullary hematopoiesis (EMH) is a rare finding in hematology. A 73-year-old female patient with a 1-week history of severe progressive dyspnea was examined, and computed tomography (CT) showed a paratracheal mass 3 cm in size located 1 cm below the vocals cords and causing obliteration of the tracheal airway. Cytology of a needle biopsy revealed EMH. External radiotherapy of 200-cGy fractions to a total dose of 2000 cGy was administered with 3-dimensional conformal planning to treat the progressive symptoms. The patient's clinical symptoms started to improve 2 days after radiotherapy and had completely disappeared after 7 days. CT scans showed complete response on follow-up at 1 week to 5 months after radiotherapy. Mature and immature hematopoietic cells and many adipose cells were seen in the pretreatment samples. Histologic findings in the posttreatment samples showed that these cells had completely disappeared due to the conformal radiotherapy. On the basis of clinical, radiologic, and histologic results, we suggest that conformal radiotherapy may be useful for the treatment of paratracheal localization of EMH because good tumoral irradiation was obtained in this case, with the protection of normal tissues.

show abstract

A Rare Case of Perirenal Myelolipoma: Diagnostic Approach and Therapeutic Strategy

Cited by 4 publications

References 4 publications

A Rare Case of an Extra-Adrenal Myelolipoma Arising in the Renal Sinus: A Case Report and Review of the Literature

A Rare Case of an Extra-Adrenal Myelolipoma Arising in the Renal Sinus: A Case Report and Review of the Literature

Two Siblings With Untreated CYP21 Deficiency and Giant Myelolipomas

Paratracheal Extramedullary Hematopoiesis

Contact Info

Product

Resources

About