A Rare Case of Peritoneal Dialysis-Associated Peritonitis with <i>Sphingomonas koreensis</i>

Wallner, Julia; Frei, Reno; Burkhalter, Felix

doi:10.3747/pdi.2015.00065

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Isolates from four of these six patients were identified as multidrug-resistant S. koreensis , a nonfermenting gram-negative bacillus previously reported in only two clinical cases. 19,20 This cluster triggered an epidemiologic investigation that used both culture-based and genomics-based techniques to identify possible sources and to inform effective intervention strategies.…”

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confidence: 99%

Investigation of a Cluster of Sphingomonas koreensis Infections

et al. 2018

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BACKGROUND Plumbing systems are an infrequent but known reservoir for opportunistic microbial pathogens that can infect hospitalized patients. In 2016, a cluster of clinical sphingomonas infections prompted an investigation. METHODS We performed whole-genome DNA sequencing on clinical isolates of multidrug-resistant Sphingomonas koreensis identified from 2006 through 2016 at the National Institutes of Health (NIH) Clinical Center. We cultured S. koreensis from the sinks in patient rooms and performed both whole-genome and shotgun metagenomic sequencing to identify a reservoir within the infrastructure of the hospital. These isolates were compared with clinical and environmental S. koreensis isolates obtained from other institutions. RESULTS The investigation showed that two isolates of S. koreensis obtained from the six patients identified in the 2016 cluster were unrelated, but four isolates shared more than 99.92% genetic similarity and were resistant to multiple antibiotic agents. Retrospective analysis of banked clinical isolates of sphingomonas from the NIH Clinical Center revealed the intermittent recovery of a clonal strain over the past decade. Unique single-nucleotide variants identified in strains of S. koreensis elucidated the existence of a reservoir in the hospital plumbing. Clinical S. koreensis isolates from other facilities were genetically distinct from the NIH isolates. Hospital remediation strategies were guided by results of microbiologic culturing and fine-scale genomic analyses. CONCLUSIONS This genomic and epidemiologic investigation suggests that S. koreensis is an opportunistic human pathogen that both persisted in the NIH Clinical Center infrastructure across time and space and caused health care-associated infections. (Funded by the NIH Intramural Research Programs.)

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Investigation of a Cluster of Sphingomonas koreensis Infections

et al. 2018

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“…Another dominant pathogen, Sphingomonas koreensis, is commonly found in aquatic environments like mineral water [76]. However, it has also been reported as the causative agent of meningitis and polymicrobial peritonitis in humans [77,78]. Dietzia maris is another significant pathogen, which is regarded as an opportunistic infection depending on a variety of factors including the presence of foreign material (prosthetic hip) [79], the patient's immunological status, or epidemiological risk factors, such as animal interaction and work-related exposure to animal farms [80].…”

Section: Pathogenic Bacteriamentioning

confidence: 99%

“…The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/ani13243879/s1, References [72,73,[77][78][79][80][81]83,[93][94][95][96][97][98][99] are cited in the supplementary materials. Table S1: The identified potentially pathogenic bacteria carried by captive Baikal teal and common teal in this study; Table S2: Relative abundance of the dominant gut bacterial phyla in different groups; Table S3: Relative abundance of the dominant gut bacterial genera in different groups; Table S4: NMDS and ANOSIM test of difference groups; Table S5: Co-occurrence network topological features statistics; Table S6: Classification information of keystone taxa in gut bacterial co-occurrence network; Table S7: The intestinal bacterial and potentially pathogenic sequences across the samples; Table S8: The difference in the relative abundance of potentially pathogenic bacteria observed among different groups; Figure S1: One-way ANOVA with Duncan's post-hoc test showed significant differences in relative abundance across groups at the phyla level.…”

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Impact of Season on Intestinal Bacterial Communities and Pathogenic Diversity in Two Captive Duck Species

Sakda,

Xiang,

Song

et al. 2023

Animals

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Vertebrates and their gut bacteria interact in complex and mutually beneficial ways. The intestinal microbial composition is influenced by several external influences. In addition to food, the abiotic elements of the environment, such as temperature, humidity, and seasonal fluctuation are also important determinants. Fecal samples were collected from two captive duck species, Baikal teal (Sibirionetta formosa) and common teal (Anas crecca) across four seasons (summer, autumn, winter, and spring). These ducks were consistently fed the same diet throughout the entire experiment. High throughput sequencing (Illumina Mi-seq) was employed to analyze the V4–V5 region of the 16sRNA gene. The dominant phyla in all seasons were Proteobacteria and Firmicutes. Interestingly, the alpha diversity was higher in winter for both species. The NMDS, PCoA, and ANOSIM analysis showed the distinct clustering of bacterial composition between different seasons, while no significant differences were discovered between duck species within the same season. In addition, LefSe analysis demonstrated specific biomarkers in different seasons, with the highest number revealed in winter. The co-occurrence network analysis also showed that during winter, the network illustrated a more intricate structure with the greatest number of nodes and edges. However, this study identified ten potentially pathogenic bacterial species, which showed significantly enhanced diversity and abundance throughout the summer. Overall, our results revealed that season mainly regulated the intestinal bacterial community composition and pathogenic bacteria of captive ducks under the instant diet. This study provides an important new understanding of the seasonal variations in captive wild ducks’ intestinal bacterial community structure. The information available here may be essential data for preventing and controlling infections caused by pathogenic bacteria in captive waterbirds.

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Acinetobacter , Chryseobacterium , Moraxella , Branhamella and Other Nonfermentative Gram‐Negative Rods

Cools,

Nemec,

Abeele

et al. 2023

ClinMicroNow

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This chapter covers the organisms which belong to a group of taxonomically and phylogenetically diverse, Gram‐negative, non‐fermentative rods and coccobacilli. Most of the organisms are found in the environment, that is, soil and water. For each group of closely related species, the chapter presents their taxonomic history, addresses the clinical importance of the species, and describes the phenotypic data that are useful to differentiate this group from other groups and to differentiate the species within this group. It discusses antibiotic susceptibility characteristics and treatment options. Decisions regarding the significance of GNF in a clinical specimen must consider the clinical condition of the patient and the source of the specimen submitted for culture. Identification of GNF may be important to document health care‐related outbreaks linked to hospital environments or medical devices.

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A Rare Case of Peritoneal Dialysis-Associated Peritonitis with Sphingomonas koreensis

Cited by 4 publications

References 6 publications

Investigation of a Cluster of Sphingomonas koreensis Infections

Investigation of a Cluster of Sphingomonas koreensis Infections

Impact of Season on Intestinal Bacterial Communities and Pathogenic Diversity in Two Captive Duck Species

Acinetobacter , Chryseobacterium , Moraxella , Branhamella and Other Nonfermentative Gram‐Negative Rods

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