A Rare Case of Primary Squamous Cell Carcinoma of the Stomach and a Review of the 56 Cases Reported in Japan

Abstract

We report an extremely rare case of primary squamous cell carcinoma of the stomach. A 69-year-old man was admitted to our hospital with a 2-month history of dysphagia and tarry stools. Endoscopic examination revealed a cauliflower-shaped protruding mass along the lesser curvature of the gastric cardia. Biopsy of the lesion revealed squamous cell carcinoma of the stomach. Computed tomography revealed a thickened stomach wall and a mass protruding into the gastric lumen. Total gastrectomy with splenectomy, distal pancreatectomy, and Roux-en-Y reconstruction was performed, together with a lower thoracic esophagectomy via a left thoracotomy. Histopathological examination of the specimen revealed well-differentiated squamous cell carcinoma of the stomach. Postoperative follow-up was uneventful for the first 18 months. However, multiple liver metastases and para-aortic lymph node metastasis developed subsequently. Despite systemic combination chemotherapy, the patient died because of progression of the recurrent tumors. Here, we review the characteristics of 56 cases of gastric squamous cell carcinoma reported in Japan.

Primary Gastric Squamous Cell Carcinoma Presenting as a Huge Subepithelial Tumor: A Case Report

“…The prognosis of primary gastric squamous cell carcinoma was reported to be superior (21) or less superior (3) to gastric adenocarcinoma according to the stage of diagnosis. However, squamous cell carcinoma of the stomach has generally shown poor results because it is usually diagnosed late to the advanced stage and often aggressively metastasizes to the lymphovascular serosa and liver (2)(3). The overall survival rate of the patient is between 7 months and 8 years (22).…”

“…The cause of this cancer has not yet been clearly identified. The cancer usually occurs in men, with a male to female ratio of 5 : 1 (2)(3). Most cases occur in the sixth decade of life (4).…”

Primary squamous cell carcinoma of the stomach presenting as a huge retroperitoneal tumor: A case report

“…However, gastric SCC generally had a poor outcomes because of that is usually diagnosed at an advanced stage and aggressively metastasizes to the lymph nodes and the liver (1,7,8). Chemotherapy combined with surgical resection is reported to improve the prognosis (9).…”

A clinical case of primary gastric squamous cell carcinoma

“…По данным разных авторов [1,2,5], плоскоклеточный рак желудка чаще встречается у мужчин (соотношение 4-5:1) в возрасте старше 50 лет, к моменту диагностики, как правило, имеет местно-распространенную или генерализованную стадию, часто осложняется кровотечением, а также развитием анемии без явных признаков кровотечения. D. Callacondo и соавт.…”