A Rare Case of Systemic Adult Burkitt Lymphoma Presenting as Acute Acalculous Cholecystitis

Doherty, Bryan; Palmer, William C.; Cvinar, Jessica; Sadek, Nora

doi:10.14309/crj.0000000000000048

Cited by 5 publications

(6 citation statements)

References 18 publications

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“…Malignant lymphoma of the gallbladder is a rare form of gallbladder malignancy, which accounts for 0.1%-0.2% of all gallbladder cancers[ 1 - 3 ]. In previous reports, most of these malignancies were documented to be diffuse large B-cell lymphomas and MALTomas[ 2 , 4 ], and only two reports had documented Burkitt’s lymphoma of the gallbladder[ 6 , 7 ]. Compared to previous cases, the present case yielded some interesting clinical and imaging findings.…”

Section: Discussionmentioning

confidence: 99%

“…In almost all cases of this malignancy, patients are diagnosed as having gallbladder adenocarcinoma or cholecystitis at the time of surgery, and preoperative diagnosis is extremely difficult. Although several reports have documented malignant lymphomas of the gallbladder, most of these malignancies are diffuse large B-cell lymphomas and mucosa-associated lymphoid tissue-type lymphomas (MALTomas)[ 2 , 4 , 5 ], and only two reports have previously documented Burkitt’s lymphoma of the gallbladder[ 6 , 7 ]. Herein, we report the case of a patient with Burkitt’s lymphoma of the gallbladder mimicking gallbladder adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Gallbladder Burkitt’s lymphoma mimicking gallbladder cancer: A case report

Hosoda¹,

Shimizu²,

Koyama³

et al. 2022

WJG

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BACKGROUND Malignant lymphoma is a rare form of gallbladder malignancy. Most of these malignancies are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas; however, Burkitt’s lymphoma of the gallbladder is extremely rare, and only two previous reports are available in the literature. Herein, we report a rare case of Burkitt’s lymphoma of the gallbladder mimicking gallbladder adenocarcinoma. CASE SUMMARY An 83-year-old man with no abdominal complaints was found to have a gallbladder tumor and periportal lymph node enlargement on computed tomography (CT) performed for hypertension screening. His laboratory data revealed slightly elevated serum levels of carcinoembryonic antigen and soluble interleukin 2 receptor. Imaging examinations revealed two irregular and contrast-enhanced masses extending into the gallbladder lumen, but these did not infiltrate the serosa. Moreover, a periportal lymph node had enlarged to 30 mm. Based on these findings, we diagnosed the patient as having gallbladder adenocarcinoma with lymph node metastasis, which was treated using bile duct resection with gallbladder bed resection and periportal lymph node dissection. However, the patient was finally diagnosed as having Burkitt’s lymphoma. Although the surgical margin was pathologically negative, recurrence was noted at the hepatic radical margin and superior pancreaticoduodenal lymph nodes on positron emission tomography/CT soon after discharge. Thus, he was referred to a hematologist and started receiving treatment with reduced-dose cyclophosphamide, doxorubicin, vincristine, and prednisone. CONCLUSION Burkitt’s lymphoma can occur in the gallbladder. Biopsy can be useful in cases with findings suggestive of gallbladder malignant lymphoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gallbladder Burkitt’s lymphoma mimicking gallbladder cancer: A case report

Hosoda¹,

Shimizu²,

Koyama³

et al. 2022

WJG

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“…Primary lymphoma of the gallbladder is rare but likely fits on the spectrum of lymphomas occurring in the gastrointestinal tract[ 5 , 7 ]. There are several case reports of acute cholecystitis as the initial presentation of lymphoma of the gallbladder and all describe non-Hodgkin's lymphoma or its subtypes on histopathology[ 2 - 5 ]. On the contrary, our case report describes Hodgkin’s lymphoma of the portal lymph nodes, and benign pathology of the gallbladder itself, presenting as ruptured cholecystitis and mimicking gallbladder adenocarcinoma on imaging.…”

Section: Discussionmentioning

confidence: 99%

“…Other authors have written about clinical situations where there is a mass in the region of the gallbladder or biliary ducts causing acute acalculous cholecystitis. In these settings, the distinction between lymphoma and gallbladder adenocarcinoma relies on histopathological assessment[ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Hodgkin lymphoma masquerading as perforated gallbladder adenocarcinoma: A case report

Manesh¹,

Henry²,

Gallagher³

et al. 2021

WJGS

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BACKGROUND There are several case reports of acute cholecystitis as the initial presentation of lymphoma of the gallbladder; all reports describe non-Hodgkin lymphoma or its subtypes on histopathology of the gallbladder tissue itself. Interestingly, there is no description in the literature of Hodgkin lymphoma causing hilar lymphadenopathy, inevitably presenting as ruptured cholecystitis with imaging mimicking gallbladder adenocarcinoma. CASE SUMMARY A 48-year-old man with a past medical history of diabetes mellitus presented with progressive abdominal pain, jaundice, night sweats, weakness, and unintended weight loss for one month. Work-up revealed a mass in the region of the porta hepatis causing obstructions of the cystic and common hepatic ducts, gallbladder rupture, as well as retroperitoneal lymphadenopathy. The clinical picture and imaging findings were suspicious for locally advanced gallbladder adenocarcinoma causing ruptured cholecystitis and cholangitis, with metastases to retroperitoneal lymph nodes. Minimally invasive techniques, including endoscopic duct brushings and percutaneous lymph node biopsy, were inadequate for tissue diagnosis. Therefore, this case required exploratory laparotomy, open cholecystectomy, and periaortic lymph node dissection for histopathological assessment and definitive diagnosis. Hodgkin lymphoma was present in the lymph nodes while the gallbladder specimen had no evidence of malignancy. CONCLUSION This clinical scenario highlights the importance of histopathological assessment in diagnosing gallbladder malignancy in a patient with gallbladder perforation and a grossly positive positron emission tomography/computed tomography scan. For both gallbladder adenocarcinoma and Hodgkin lymphoma, medical and surgical therapies must be tailored to the specific disease entity in order to achieve optimal long-term survival rates.

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“…That is because preoperative diagnosis is exceedingly challenging. Although several reports have documented malignant gallbladder lymphomas, most of these malignancies are diffuse large B-cell lymphomas (DLBCL) or Marginal Zone Lymphomas (MZL) [3,[5][6], and only three reports have previously documented gallbladder Burkitt's lymphoma (BL) [1,[7][8]. Herein, we report the first case of a child with gallbladder BL.…”

Section: Introductionmentioning

confidence: 98%

Gallbladder Burkitt’s Lymphoma in a Child Living with HIV: A Case Report

Duarte,

Bueno,

Sanches

et al. 2024

Preprint

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Malignant lymphoma is an unusual form of gallbladder neoplasm. Almost all of these tumors are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas. Herein, we report a rare case of a gallbladder Burkitt’s lymphoma (BL) in a child living with HIV. As far as we are concerned, this is the first report in the pediatric population and in an individual living with HIV. The patient attended the Federal Hospital of Lagoa, Rio de Janeiro, Brazil, underwent cholecystectomy and the postoperative pathological analysis of the gallbladder revealed a diagnosis of BL. Also, HIV serology was performed and returned positive. She was transferred to the Martagão Gesteira Institute of Pediatrics and Childcare for oncological treatment, dying from sepsis and disease progression about 18 months later. Patient did not undergo ART/cART. Previous cases of gallbladder BL were analyzed to characterize the clinicopathological features. BL can occur in the gallbladder both in the context of HIV infection and in the pediatric population. Biopsy is mandatory in cases with suggestive findings of lymphoma, and an early diagnosis can change the course of the disease. Furthermore, the case highlights the importance of an early initiation of ART/cART in people living with HIV (PLWH).

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A Rare Case of Systemic Adult Burkitt Lymphoma Presenting as Acute Acalculous Cholecystitis

Cited by 5 publications

References 18 publications

Gallbladder Burkitt’s lymphoma mimicking gallbladder cancer: A case report

Gallbladder Burkitt’s lymphoma mimicking gallbladder cancer: A case report

Hodgkin lymphoma masquerading as perforated gallbladder adenocarcinoma: A case report

Gallbladder Burkitt’s Lymphoma in a Child Living with HIV: A Case Report

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