A rare case of underlying pulmonary sequestration in a patient with recently diagnosed medium and large vessel vasculitis

Malik, Shahid; Khurana, Sakshi; Vasudevan, Vishnu; Gupta, Nikhil

doi:10.4103/0970-2113.129871

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Infected pulmonary sequestration due to mycobacteria, such as Mycobacterium tuberculosis and Mycobacterium avium-intracellulare complex, occur rarely[ 1 ]. Malik et al [ 3 ] also demonstrated an asymptomatic intralobar pulmonary sequestration, associated with medium - and large vessel vasculitis[ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between intralobar pulmonary sequestration and type A aortic dissection: A case report

Wang¹,

Chen²,

Lin³

2023

World J Clin Cases

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BACKGROUND Pulmonary sequestrations often lead to serious complications such as infections, tuberculosis, fatal hemoptysis, cardiovascular problems, and even malignant degeneration, but it is rarely documented with medium and large vessel vasculitis, which is likely to result in acute aortic syndromes. CASE SUMMARY A 44-year-old man with a history of acute Stanford type A aortic dissection status post-reconstructive surgery five years ago. The contrast-enhanced computed tomography of the chest at that time had also revealed an intralobar pulmonary sequestration in the left lower lung region, and the angiography also presented perivascular changes with mild mural thickening and wall enhancement, which indicated mild vasculitis. The intralobar pulmonary sequestration in the left lower lung region was long-term unprocessed, which was probably associated with his intermittent chest tightness since no specific medical findings were detected but only positive sputum culture with mycobacterium avium-intracellular complex and Aspergillus. We performed uniportal video-assisted thoracoscopic surgery with wedge resection of the left lower lung. Hypervascularity over the parietal pleura, engorgement of the bronchus due to a moderate amount of mucus, and firm adhesion of the lesion to the thoracic aorta were histopathologically noticed. CONCLUSION We hypothesized that a long-term pulmonary sequestration-related bacterial or fungal infection can result in focal infectious aortitis gradually, which may threateningly aggravate the formation of aortic dissection.

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Section: Discussionmentioning

confidence: 99%

Relationship between intralobar pulmonary sequestration and type A aortic dissection: A case report

Wang¹,

Chen²,

Lin³

2023

World J Clin Cases

View full text Add to dashboard Cite

show abstract

“…Malik et al also demonstrated an asymptomatic intralobar pulmonary sequestration, associated with medium -and large vessel vasculitis (3). …”

mentioning

confidence: 98%

The Relationship Between Intralobar Pulmonary Sequestration and Type a Aortic Dissection: A Case Report

Lin¹,

Chen²

2021

Preprint

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Background: Pulmonary sequestrations often lead to serious complications such as infections, tuberculosis, fatal hemoptysis, cardiovascular problems, and even malignant degeneration, but it is rarely documented with medium and large vessel vasculitis, which is likely to result in acute aortic syndromes.Case presentation: A 44-year-old man with a history of acute Stanford type A aortic dissection status post-reconstructive surgery five years ago. The contrast-enhanced computed tomography (CT) of the chest at that time had also revealed an intralobar pulmonary sequestration in the left lower lung region, and the angiography also presented perivascular changes with mild mural thickening and wall enhancement, which indicated mild vasculitis. The intralobar pulmonary sequestration in the left lower lung region was long-term unprocessed, which was probably associated with his intermittent chest tightness since no specific medical findings were detected but only positive sputum culture with mycobacterium avium-intracellulare complex and Aspergillus. We performed uniportal video-assisted thoracoscopic surgery with wedge resection of the left lower lung. Hypervascularity over the parietal pleura, engorgement of the bronchus due to a moderate amount of mucus, and firm adhesion of the lesion to the thoracic aorta were histopathologically noticed.Conclusion: We hypothesized that a long-term pulmonary sequestration-related bacterial and fungal infection can result in focal infectious aortitis gradually, which may threateningly contribute to aortic dissection.

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Gefitinib in the Treatment of a Pulmonary Sequestration Patient Complicated by Large Cell Lung Carcinoma

Shi

Wang

et al. 2018

Journal of Thoracic Oncology

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Pulmonary sequestration is a rare malformation in which nonfunctioning lung tissue is separated from the rest of the lung. 1 It is not attached to the pulmonary arterial blood supply and is supplied with blood from an unusual source, often from an artery of the systemic circulation. 2 Large cell lung carcinoma (LCLC) comprises a heterogeneous group of undifferentiated malignant neoplasms and accounts for 5% to 10% of all lung cancers. 3 Gefitinib is an EGFR inhibitor that interrupts signaling through the EGFR in target cells. Gefitinib has been widely used for EGFR-positive lung cancers, especially for NSCLC. 4 However, there have been few reports of LCLC being treated with gefitinib. Patients with LCLC combined with pulmonary sequestration are extremely rare. Here, we describe such a rare case of a 51-year-old Chinese woman with outcomes that were satisfactory after oral gefitinib. A 51-year-old Chinese woman was admitted to Tianjin Chest Hospital on June 9, 2014, after having suffered from intermittent fever for half a year and chest distress for 1 month. The patient initially received antiinflammatory treatment in other hospitals, but her symptoms were not significantly relieved. Chest computed tomography (CT) showed some shadow in the lobe of left lung; a hilar mass (Fig. 1A); and multiple lymph nodes in left supraclavicular, alar, pulmonary hilum and mediastinum, which showed partial enlargement. The left lower lobe of the lung was atrophied, and it closely adhered to the chest wall, diaphragm, pericardium, and posterior. The mass was hard and invaded the posterior chest wall, pericardium, and mediastinum. In addition, an

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A rare case of underlying pulmonary sequestration in a patient with recently diagnosed medium and large vessel vasculitis

Cited by 3 publications

References 11 publications

Relationship between intralobar pulmonary sequestration and type A aortic dissection: A case report

Relationship between intralobar pulmonary sequestration and type A aortic dissection: A case report

The Relationship Between Intralobar Pulmonary Sequestration and Type a Aortic Dissection: A Case Report

Gefitinib in the Treatment of a Pulmonary Sequestration Patient Complicated by Large Cell Lung Carcinoma

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