A rare cause of infection, Raoultella planticola: emerging threat and new reservoir for carbapenem resistance

Demiray, Tayfur; Köroğlu, Mehmet; Özbek, Ahmet; Altındiş, Mustafa

doi:10.1007/s15010-016-0900-4

Cited by 43 publications

(37 citation statements)

References 20 publications

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“…These bacteria are naturally resistant to aminopenicillins because of the possession of chromosomal, class A β-lactamase genes (Walckenaer et al 2004). Additionally, many different β-lactamase genes have been reported in this genus so far, including bla TEM , bla SHV , bla CTX-M , bla IMP , bla KPC , bla NDM , bla OXA , and bla OXA-48 (Zurfluh et al 2013;Sun et al 2015;Demiray et al 2016;Yao et al 2017). In this study, bla TEM , bla GES , bla KPC , and bla ORN genes characteristic of R. ornithinolytica were identified in all of the strains with the exception of one (228A).…”

Section: Discussionmentioning

confidence: 99%

Diversity of β-lactam resistance genes in gram-negative rods isolated from a municipal wastewater treatment plant

2019

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Urban wastewater treatment plants (UWTPs) are considered hot spots for the accumulation and transfer of antibiotic resistant bacteria and their genes. We investigated the prevalence, diversity, and genomic localization of β-lactamase resistance genes in wastewater from different parts of an UWTP, such as raw wastewater, wastewater from biological reactor, and treated wastewater, collected from the UWTP of Warsaw, Poland. In this study, we focused on gram-negative rods, mainly Enterobacteriaceae, and used Multiplex PCR to identify various β-lactamase resistance genes (bla). Susceptibility to a number of antibiotics and genomic localization of β-lactamase resistance genes were then determined using disc-diffusion and Southern hybridization methods, respectively. No differences in the frequency of different types of bla genes between the sampling points were discerned. Three new variants of β-lactamase genes (bla CMY-157 , bla MOX-13 , and bla FOX-15 ) were identified. Four bla genes (bla TEM-12 , bla TEM-30 , bla TEM-47/68 , bla ACT ) that had never been found in UWTPs were identified in this study. Nine of the identified bla genes had been found in the same environment previously. The bla FOX-15 variant on a Kluyvera sp. plasmid and bla GES type on Raoultella spp. plasmids were observed for the first time in these genera. There was a decrease in the number of multidrug resistant strains in the effluent compared to the influent. Finally, a significantly higher number of cefotaxime and carbapenem unsusceptible strains were detected in the influent than in the effluent. The results strongly support the hypothesis of UWTPs as a hot spot for antibiotic resistant genes (ARGs) and antibiotic resistant bacteria (ARB) accumulation and indicate that β-lactamase genes are widely disseminated among gram-negative rods isolated from this environment.

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Section: Discussionmentioning

confidence: 99%

Diversity of β-lactam resistance genes in gram-negative rods isolated from a municipal wastewater treatment plant

2019

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“…50,51 Other Raoultella species were also described as exhibiting OXA-48 carbapenemase. [52][53][54][55] Nonetheless, a few strains of R. ornithinolytica generating simultaneously different types of beta-lactamase (TEM, SHV, KPC and OXA) were described. 42,56 The first case of co-existence of bla KPC-2 and bla IMP-4 carbapenemase genes in the genus Raoultella was reported by Zheng et al (2015) in a 13-year-old male patient with postoperative infection after an orthopedic surgery.…”

Section: Virulence and Resistancementioning

confidence: 99%

<p><em>Raoultella ornithinolytica</em>: Emergence and Resistance</p>

Hajjar¹,

Ambaraghassi²,

Sebajang³

et al. 2020

IDR

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Raoultella ornithinolytica is an encapsulated Gram-negative, oxidase-negative, catalase-positive, aerobic, non-motile rod that belongs to the Enterobacteriaceae family. This bacterium was initially classified in the genus Klebsiella as Klebsiella ornithinolytica, until the creation of the genus Raoultella in 2001. R. ornithinolytica is usually found in water environments and soil, and due to its ability to convert histidine to histamine, it has been associated with histamine poisoning in humans. R. ornithinolytica is an emerging entity in human infections, with several reports of virulent infections in comorbid at-risk patients. Increasing reports are potentially due to better and more precise identification tools. The objective of this article is to provide a comprehensive review of reported cases of R. ornithinolytica infections, the emergent virulence of described multiresistant strains, and an overview of currently used identification methods.

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“…Emerging cases of bla OXA-48 in Taiwan from January 2012 to May 2014 suggest expanding ability to confer carbapenem resistance in the Enterobacteriaceae [Ma 2015]. bla OXA-48 was responsible for carbapenem resistance in a collection of Raoultella planticola isolates from January 2011 to December 2015 at a Turkish hospital [Demiray 2016]. A plasmid borne bla OXA-48 contained on Tn1999.2 was reported in a R. ornithinolytica clinical isolate from Lebanon in 2016 [Al-Bayssari 2016].…”

Section: Oxa-48-like Family Membersmentioning

confidence: 99%

The rapid spread of carbapenem-resistant Enterobacteriaceae

Potter

D’Souza

Dantas

2016

Drug Resistance Updates

335

211

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Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Successful expansion of Enterobacteriaceae clonal groups and frequent horizontal gene transfer of carbapenemase expressing plasmids are causing increasing carbapenem resistance. Recent advances in genetic and phenotypic detection facilitate global surveillance of CRE diversity and prevalence. In particular, whole genome sequencing enabled efficient tracking, annotation, and study of genetic elements colocalized with carbapenemase genes on chromosomes and on plasmids. Improved characterization helps detail the co-occurrence of other antibiotic resistance genes in CRE isolates and helps identify pan-drug resistance mechanisms. The novel β-lactamase inhibitor, avibactam, combined with ceftazidime or aztreonam, is a promising CRE treatment compared to current colistin or tigecycline regimens. To halt increasing CRE-associated morbidity and mortality, we must continue quality, cooperative monitoring and urgently investigate novel treatments.

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A rare cause of infection, Raoultella planticola: emerging threat and new reservoir for carbapenem resistance

Cited by 43 publications

References 20 publications

Diversity of β-lactam resistance genes in gram-negative rods isolated from a municipal wastewater treatment plant

Diversity of β-lactam resistance genes in gram-negative rods isolated from a municipal wastewater treatment plant

<p><em>Raoultella ornithinolytica</em>: Emergence and Resistance</p>

The rapid spread of carbapenem-resistant Enterobacteriaceae

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