A rare complication of full‐thickness rectal prolapse mimicking tumour

Abstract

Many factors in obesity are associated with colon cancer including increased blood levels of leptin, insulin, IL-6, TNF-a and decreased blood level of adiponectin. These increase signal pathways of importance to carcinogenesis and prognosis including PI3K ⁄ Akt, MAPK and STAT3 [7]. Recently, it has been found that an elevated leptin at the concentration of 50 ng ⁄ ml increases expression of vascular endothelial growth factor (VEGF) in immorto mouse cells and in human endothelial cells [8]. VEGF is well know to cause angiogenesis and is critical for cancer metastasis and progression [8].