A Rare der(Y)t(Y;1)(q12;q12) in a Patient with Essential Thrombocythemia

Abstract

Among hematologic diseases, structural abnormalities of autosomal chromosomes are well-known, but cases involving the sex chromosomes are uncommon. Duplications of the long arm of chromosome 1 have been reported in several hematologic diseases including myelodysplastic syndrome, myeloproliferative neoplasms, acute myeloid leukemia, acute lymphoblastic leukemia, and Burkitt lymphoma. However, dup(1q) as a der(Y) t(Y;1)(q12;q12) is very rare. Here, we report a case of essential thrombocythemia harboring der(Y)t(Y;1)(q12;q12) with literature review.

Quality Parameters of Mechanically Extracted Edible Macauba Oils (Acrocomia aculeata) for Potential Food and Alternative Industrial Feedstock Application

“…Accordingly to Rodriguez-Amaya et al [13] and Rufino et al [21] the contents of carotenoids in the mesocarp of A. aculeata surpasses of other tropical fruits. Considering the increasing demand for health-related natural products from consumers, [23,24] the nutraceutical potential natural appeal of macauba in its natural state may be considered as one of its remarkable characteristics. [23,24] The highly unsaturated structures of carotenoids are, on the one hand, responsible for their functional properties.…”

“…Considering the increasing demand for health-related natural products from consumers, [23,24] the nutraceutical potential natural appeal of macauba in its natural state may be considered as one of its remarkable characteristics. [23,24] The highly unsaturated structures of carotenoids are, on the one hand, responsible for their functional properties. On the other hand, the significant correlated numbers of double bonds in the compounds molecule creates stability challenges.…”

“…Consumers have shown an increasing demand for natural products which tends to be associated with the health‐related benefits obtained from several classes of bioactive compounds . MUFA, as well as carotenoids, tocopherols, tocotrienols, among other micronutrients, have been related to human blood cholesterol‐lowering as well as to reducing the incidence of coronary heart and various other human diseases .…”

“…[13,18,[20][21][22] Consumers have shown an increasing demand for natural products which tends to be associated with the health-related benefits obtained from several classes of bioactive compounds. [23,24] MUFA, as well as carotenoids, tocopherols, tocotrienols, among other micronutrients, have been related to human blood cholesterol-lowering as well as to reducing the incidence of coronary heart and various other human diseases. [25,26] Additionally, carotenoids together with tocols, [27] contribute to vegetable oil stability due to their chemical action (antioxidant) and preservation properties.…”

der(Y)t(Y;1)(q11-12;q12-21)

“…Note Chronic myeloid neoplasm in 15 patients (15 males aged 15 to 75 years; median 63 years). Among them, there were 7 cases of myelodysplastic syndrome (MDS) (Hollings et al, 1988;Thompsonet al, 1991;Wei et al, 1993;Raymakersetal et al,1996;Djordjevicet al, 2008;Wan et al, 2001;Sanford et al, 2015), 1 polycythemia vera (Testa et al, 1981), 1 idiopathic myelofibrosis (Michaux et a., l 1996), 1 post-polycythemic myelofibrosis (Manabe et al, 2013), 1 essential thrombocythemia (Lim et al,2016), 3 chronic myelomonocytic leukemia (Hollings et al, 1988;Michaux et al, 1996;Chen et al, 2010) and 1 atypical chronic myeloid leukemia (Ohsaka Hisa 2002). Acute myeloid leukemia in 5 (aged 0 to 86 years, median 63 years): 2 acute myeloblastic leukemia with maturation (AML-M2) (Haupt et al, 1991;Singh et al, 1993), 2 acute myelomonocytic leukemia (AML-M4) (Bao et al, 2006;Brown et al, 2012) and 1 acute monoblastic leukemia (AML-M5) (Tuborgh et al, 2013).…”