A Rare Presentation of Stauffer’s Syndrome Associated with Renal Cell Carcinoma

Abstract

Renal cell carcinoma (RCC) is a primary tumor of the kidneys. It is characterized by the triad of flank pain, hematuria, and a palpable flank mass. However, most RCC patients present with a paraneoplastic manifestation of the disease. Stauffer's syndrome (a non-metastatic hepatic dysfunction) is a rare paraneoplastic manifestation associated with RCC. We report the case of a 30-year-old male, obese, who presented with hematuria and was found to have a right renal mass secondary to RCC. During his hospital stay, the patient developed acute hepatic dysfunction that resolved rapidly after tumor resection.

Non-metastatic Nephrogenic Hepatic Dysfunction (Stauffer Syndrome) and Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) in a Patient With Renal Cell Carcinoma Coinciding With Liposarcoma

“…The fluctuating nature of lab results during the patient's illness, such as hyponatremia and elevated platelet count, ALP, and AST levels, emphasizes the need for careful monitoring to guide therapy and evaluate treatment effectiveness. This case ultimately serves as a reminder of the significance of longterm patient care, follow-up, and possibly future therapy or interventions even after discharge, particularly in situations involving concurrent malignancies and related disorders [10]. From our case, we see that the patient's labs worsened soon after the procedure but returned to normal levels a few days later.…”

Biochemical alterations and paraneoplasic syndromes in patients with renal carcinoma

“…Observó que posterior a la nefrectomía las alteraciones hepáticas se resolvían pero aparecían nuevamente en caso de recurrencia tumoral. (12)(13)(14) Este famoso síndrome paraneo- hepática están asociadas a la producción errática de interleucina. (3,15) La producción de IL-6 produce daño celular a los hepatocitos con la activación inmunológica mediante linfocitos T y anticuerpos contra antígenos hepáticos.…”