A Rat Model of Ischemic Cardiomyopathy for Investigating Left Ventricular Volume Reduction Surgery

Abstract

This model enables reproducible physiological evaluation of the LV after VRS, and since the rats show postoperative survival, it provides a useful tool for various investigations.

Large Animal Models of Chronic Heart Failure (CHF)

“…The disadvantages, on the other hand, include fatal arrhythmias despite prophylactic administration of anti-arrhythmic agents, the development of postoperative adhesions and scar tissue, which make subsequent operations more dangerous and difficult, and the need for personnel capable of surgical procedures. In summary, coronary ligation creates a robust, replicable model of ischemic heart failure in several species [31,35] including dogs [32], sheep [19,20,30,33,34], and pigs [36].…”

Intramyocardial sustained delivery of basic fibroblast growth factor improves angiogenesis and ventricular function in a rat infarct model

“…After an anterior thoracotomy at the fourth intercostal space, the proximal left anterior descending coronary artery (LAD) was ligated with a 5-0 polypropylene suture. 8 An ST elevation on electrocardiograms and color changes in the left ventricular (LV) muscle were notified in all rats. The rats awakened within 5 min after cessation of the anesthesia.…”

State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization

“…There are several models in both small [114][115][116][117] and large animals [118][119][120][121] in which a major coronary artery or multiple branches are occluded for the specific purpose of inducing significant myocardial ischemia and infarction for the subsequent analysis of neovasculogenesis and arteriogenesis in response to experimental therapies (Table 4). These models can entail permanent occlusion or a prolonged occlusion followed by reperfusion.…”