A ratiometric fluorescent sensor based on g-CNQDs@Zn-MOF for the sensitive detection of riboflavin via FRET

Feng, Shasha; Pei, Fubin; Wu, Yi; Lv, Jingjing; Hao, Qingli; Yang, Ting‐Hai; Tong, Zhaoyang; Lei, Wu

doi:10.1016/j.saa.2020.119004

Cited by 82 publications

(27 citation statements)

References 39 publications

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“…Therefore, we speculated that the fluorescence enhancement process should be attributed to FRET between MIP NPs (acceptor) and the CF (donor). [34,35] Unlike the doping rare-earth oxides, for Eu 3+ ,Tb 3+ co-doping into the Y 2 O 3 lattice at a high calcined temperatures (800 C or above), the emission spectra were observed at 610 nm for Eu 3+ 5 D 0 -7 F 2 red emission and 545 nm for Tb 3+ 5 D 4 -7 F 5 green emission, simultaneously, under the same excitation at 307 nm. [36,37] Whereas the Y 2 O 3 :(Eu 3+ ,-Tb 3+ ) shell enclosed in MIP was obtained from the hydrothermal reaction of rare-earth cations at a low temperature (110 C), it is extremely possible that there was almost no mutual interaction between rareearth ions with one another.…”

Section: Analysis Of Fluorescence Mechanismmentioning

confidence: 93%

Fluorescence detection of carbofuran in aqueous extracts based on dual‐emission SiO₂@Y₂O₃:(Eu³⁺,Tb³⁺)@MIP core‐shell structural nanoparticles

et al. 2022

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A novel double-windows fluorescence sensor for carbofuran (CF) detection was successfully developed based on rare-earth Eu,Tb-doped Y 2 O 3 @SiO 2 -based molecularly imprinted nanoparticles (MINs) with a multilayer core-shell structure. The recognition process of the MINs for CF was fairly fast and needed only $8 min to reach a dynamic equilibrium. Interestingly, one fluorescence attenuation window was found with an increase in CF concentration (Q) from 0.1 to 10 μg ml À1 and with a limit of detection (LOD) of 0.04 μg ml À1 at 544 nm belonging to the Tb 3+ emission, as well as another fluorescence enhanced window within the CF concentration range 10-100 μg ml À1 (LOD = 4 μg ml À1 ) at 617 nm of Eu 3+ emission in the dispersed rare-earth-doped MIN colloidal aqueous solution. Luminescence resonance energy transfer from CF to Eu 3+ and an inner filter effect of CF towards Tb 3+ , as well from the two independent detection windows were clearly observed simultaneously. The competition experiment displayed hardly any marked interference during detection of CF following addition of its analogues (carbaryl, isoprocarb, aldicarb, methomyl, and etofenprox). Moreover, the MINs could also be applied to accurately detect CF in rhubarb and wolfberry samples with recoveries of 85.7-92.2%. This sensing system has high specific recognition and a wide detection range for CF and provides new opportunities for pesticide detection.

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Section: Analysis Of Fluorescence Mechanismmentioning

confidence: 93%

Fluorescence detection of carbofuran in aqueous extracts based on dual‐emission SiO₂@Y₂O₃:(Eu³⁺,Tb³⁺)@MIP core‐shell structural nanoparticles

et al. 2022

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“…The nanoprobe provides a simple approach to creating a ratiometric fluorescent sensor based on the FRET process for the determination of RF in aqueous media. Capillary Electrophoresis/Laser-Induced Fluorescence 0.001-1.33 0.008 [15] HPLC/tandem mass spectrometry 0.011-53.1 0.029 [12] Ag nanoparticles modified with β-CD/Colorimetry 0.16-4.66 0.167 [36] Spectrophotometry/Absorbance at 440 nm 0.797-123 0.79 [11] Graphitic carbon nitride/Fluorimetry (FRET) 0.4-10 0.170 [16] Carbon-dot-codoped N, P/Fluorimetry (FRET) 0.5-50 0.170 [17] g-CNQDs@Zn-MOF/Fluorimetry (FRET) 0-1 0.015 [18] Sulfonated graphene/Fluorimetry (FRET) 0.4-10 1.6 [37] N,S-doped carbon dots/Fluorimetry (FRET) 0.56-7.4 1.9 [19] Graphene-PEG/Fluorescence Quenching 0-6.3 60 [38] Molecularly Imprinted Polymer (PIM)/Fluorimetry Not reported 79.7 [39] Carbon dots (N, COO − )/Fluorimetry (FRET) 0-11 0.025 This work…”

Section: Comparison With Other Methodsmentioning

confidence: 99%

“…However, these methods have multiple shortcomings, including a slow response, low selectivity, the use of a large amount of solvent, high-cost equipment, and laborious procedures. Alternatively, methods based on the FRET process using different nanoparticles as a donor have also been reported [ 16 , 17 , 18 , 19 ]. In general, these reports do not include a study of the conditions to obtain a FRET process with the highest efficiency.…”

Section: Introductionmentioning

confidence: 99%

Optimizing the Efficiency of a Cytocompatible Carbon-Dots-Based FRET Platform and Its Application as a Riboflavin Sensor in Beverages

et al. 2021

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In this work, the Förster resonance energy transfer (FRET) between carbon dots (CDs) as energy donors and riboflavin (RF) as an energy acceptor was optimized and the main parameters that characterize the FRET process were determined. The results were successfully applied in the development of an ultrasensitive ratiometric fluorescent sensor for the selective and sensitive determination of RF in different beverages. Water-soluble CDs with a high quantum yield (54%) were synthesized by a facile and direct microwave-assisted technique. The CDs were characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), Zeta potential, and UV-visible and molecular fluorescence spectroscopy. The study of the FRET process at two donor concentrations showed that the energy transfer efficiency decreases as the donor concentration increases, confirming its dependence on the acceptor:donor ratio in nanoparticle-based systems. The results show the importance of optimizing the FRET process conditions to improve the corresponding output signal. The variation in the ratiometric signal with the concentration of RF showed linearity in a concentration range of 0 to 11 µM with R2 = 0.9973 and a detection limit of 0.025 µM. The developed nanosensor showed good selectivity over other possible types of interference. The sensor was then applied for the determination of RF in beverage samples using the standard addition method with recoveries between 96% and 106%. Preliminary cytocompatibility tests carried out with breast cancer cells (MDA-MB-231) revealed the nanosensor to be cytocompatible in its working concentration regime, even after long incubation times with cells. Altogether, the developed RF determination method was found to be fast, low-cost, highly sensitive, and selective and can be extended to other samples of interest in the biological and food sectors. Moreover, thanks to its long-lasting cytocompatibility, the developed platform can also be envisaged for other applications of biological interest, such as intracellular sensing and staining for live cell microscopy.

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“…Among them, MOFs with specific functional sites have sparked a lot of interest because of their diverse structures and multifunctionalities, allowing for specific molecular recognition and fluorescence generation and/or change. When it deals with sensing and imaging, apart from encapsulation, MOFs have been investigated as new imaging probes following mainly two strategies: (1) as fluorescence quenchers toward the fluorophores of analytes based on charge transfer, 43 fluorescence resonance energy transfer (FRET), 44 or photoinduced electron transfer (PET); 45 (2)…”

Section: Biosensing and Bioimagingmentioning

confidence: 99%

Metal–organic frameworks towards bio-medical applications

Lepoitevin

Serre

2021

Mater. Chem. Front.

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A ratiometric fluorescent sensor based on g-CNQDs@Zn-MOF for the sensitive detection of riboflavin via FRET

Cited by 82 publications

References 39 publications

Fluorescence detection of carbofuran in aqueous extracts based on dual‐emission SiO₂@Y₂O₃:(Eu³⁺,Tb³⁺)@MIP core‐shell structural nanoparticles

Fluorescence detection of carbofuran in aqueous extracts based on dual‐emission SiO₂@Y₂O₃:(Eu³⁺,Tb³⁺)@MIP core‐shell structural nanoparticles

Optimizing the Efficiency of a Cytocompatible Carbon-Dots-Based FRET Platform and Its Application as a Riboflavin Sensor in Beverages

Metal–organic frameworks towards bio-medical applications

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A ratiometric fluorescent sensor based on g-CNQDs@Zn-MOF for the sensitive detection of riboflavin via FRET

Cited by 82 publications

References 39 publications

Fluorescence detection of carbofuran in aqueous extracts based on dual‐emission SiO2@Y2O3:(Eu3+,Tb3+)@MIP core‐shell structural nanoparticles

Fluorescence detection of carbofuran in aqueous extracts based on dual‐emission SiO2@Y2O3:(Eu3+,Tb3+)@MIP core‐shell structural nanoparticles

Optimizing the Efficiency of a Cytocompatible Carbon-Dots-Based FRET Platform and Its Application as a Riboflavin Sensor in Beverages

Metal–organic frameworks towards bio-medical applications

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Fluorescence detection of carbofuran in aqueous extracts based on dual‐emission SiO₂@Y₂O₃:(Eu³⁺,Tb³⁺)@MIP core‐shell structural nanoparticles

Fluorescence detection of carbofuran in aqueous extracts based on dual‐emission SiO₂@Y₂O₃:(Eu³⁺,Tb³⁺)@MIP core‐shell structural nanoparticles