Acoustic waves have a remarkable ability to transfer energy from the ground up to the uppermost layers of the atmosphere. On the ground, there are many permanent sources of infrasound, and also pulsed and/or sporadic sources (e.g., sea waves, infrasonic and sonic noise of cities, lightning, earthquakes, explosions, etc.). The infrasonic waves carry away the major part of their energy upwards through the atmosphere. What are the consequences of the upward energy transfer? What heights of the atmosphere are supplied by energy from various sources of an infrasonic wave? In most cases, the answers to these questions are not well known at present. The only opportunity to monitor the propagation of an infrasonic wave to high altitudes is to watch for its influence on the ionospheric plasma. Unfortunately, most of standard equipment for ionospheric sounding, as a rule, cannot detect plasma fluctuations in the infrasonic range. Besides, the form of an infrasonic wave strongly varies during propagation due to nonlinear effects. However, the development of the Doppler method of radiosounding of the ionosphere has enabled progress to be made. Simultaneously, the ionospheric method for sensing aboveground and underground explosions has been developed. Its main advantage is the remote observation of an explosion in the near field zone by means of short radio waves, i.e., the radio sounding of the ionosphere directly above the explosion. The theory of propagation of an acoustic pulse produced by an explosion on the ground up to ionospheric heights has been developed better than the theory for other sources, and has been quantitatively confirmed by experiments. A review of some advances in the area of infrasound investigations at ionospheric heights is given and some current problems are presented.