A reaffirmation of the retrosplenial contribution to rodent navigation: reviewing the influences of lesion, strain, and task

Harker, K. Troy; Whishaw, Ian Q.

doi:10.1016/j.neubiorev.2004.06.005

Cited by 54 publications

(49 citation statements)

References 61 publications

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“…Similar clinical features have also been reported in previous studies [4]. Interestingly, the cingulate and retrosplenial cortex have also been suggested to play a role in spatial navigation [11,23,35] and these regions were found to be atrophied in our PCA cohort. It should be noted however that the PCA group did not have more atrophy in these regions on direct comparison than the typical AD group.…”

Section: Discussionsupporting

confidence: 90%

Imaging correlates of posterior cortical atrophy

Whitwell

Jack

Kantarci

et al. 2007

Neurobiology of Aging

185

143

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The aim of this study was to compare patterns of cerebral atrophy on MRI, and neurochemistry on magnetic resonance spectroscopy (MRS), in subjects with posterior cortical atrophy (PCA) and typical Alzheimer's disease (AD). Voxel-based morphometry was used to assess grey matter atrophy in 38 subjects with PCA, 38 subjects with typical AD, and 38 controls. Clinical data was assessed in all PCA subjects. Single-voxel 1 H MRS located in the posterior cingulate was analyzed in a subset of subjects with PCA, typical AD, and control subjects. PCA showed a pattern of atrophy affecting occipital, parietal and posterior temporal lobes, compared to controls. The pattern was bilateral, but more severe on the right. Subjects with PCA showed greater atrophy in the right visual association cortex than subjects with typical AD, whereas those with AD showed greater atrophy in the left hippocampus than those with PCA. 1 H MRS suggested loss of neuronal integrity and glial activation in subjects with PCA and AD. The differing patterns of atrophy on MRI suggest that PCA should be considered a distinct entity from typical AD.

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Section: Discussionsupporting

confidence: 90%

Imaging correlates of posterior cortical atrophy

Whitwell

Jack

Kantarci

et al. 2007

Neurobiology of Aging

185

143

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“…Lesions to retrosplenial cortex (area 29) in rodents disrupts spatial navigation and maze learning (Harker and Whishaw, 2004;Lukoyanov et al, 2005). Although we examined only the responses of cells presumed to lie in areas 23 and 31 of cingulate cortex and not the closely connected areas 29 and 30, disruptions in topographic spatial orientation after retrosplenial lesions are consistent with the allocentric bias in visuospatial representations uncovered in our study.…”

Section: Spatial Deficits After Lesions Of Posterior Cingulate Cortexsupporting

confidence: 73%

Allocentric Spatial Referencing of Neuronal Activity in Macaque Posterior Cingulate Cortex

Dean¹,

Platt²

2006

J. Neurosci.

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“…For example, retrosplenial cortex is one of the many posterior parietal structures that become active during correct responses in item recognition tasks (Konishi et al, 2000), suggesting a critical role in memory retrieval (Wagner et al, 2005). In the case of spatial navigation by rats, the retrosplenial cortex has been discussed as a key player in updating visuospatial representations with movement-related (idiothetic) information (Sutherland et al, 1988;Cooper and Mizumori, 2001;Harker and Whishaw, 2004). Anatomical connections of the retrosplenial cortex support such an integrative role between visual and movement-related information since it receives input from, and returns projections to, visual association cortex, medial precentral cortex, motor cortex, anterior cingulate cortex, and the subicular complex (Vogt and Miller, 1983;Wyss and van Groen, 1992;see Fig.…”

Section: Retrosplenial (Parietal) Cortex-hippocampal Interactionsmentioning

confidence: 99%

Hippocampal and neocortical interactions during context discrimination: Electrophysiological evidence from the rat

2007

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ABSTRACT:There is substantial evidence that hippocampus plays an important role in the processing of contextual information. Its specific role, however, remains unclear. One possibility is that single hippocampal neurons represent context information so that local circuits can construct representations of the current context, and the context that is expected based on past experience. Population codes derived from input by multiple local circuits may then engage match-mismatch algorithms that compare current and expected context information to determine the extent to which an expected context has changed. The results of such match-mismatch comparisons can be used to discriminate contexts. When context changes are detected, efferent messages may be passed on to connected neocortical areas so that informed "decisions" regarding future behavioral and cognitive strategies can be made. Here, a brief review describes evidence that a primary consequence of hippocampal processing is the discrimination of meaningful contexts. Then, the functional significance of neocortical circuits that likely receive hippocampal output messages are described in terms of their contribution to the control of ongoing behavioral and cognitive strategy, especially during active navigation. It is clear from this systems view that studies of spatial navigation continue to provide researchers with an excellent model of hippocampal-neocortical interactions during learning. V V C 2007 Wiley-Liss, Inc.

show abstract

A reaffirmation of the retrosplenial contribution to rodent navigation: reviewing the influences of lesion, strain, and task

Cited by 54 publications

References 61 publications

Imaging correlates of posterior cortical atrophy

Imaging correlates of posterior cortical atrophy

Allocentric Spatial Referencing of Neuronal Activity in Macaque Posterior Cingulate Cortex

Hippocampal and neocortical interactions during context discrimination: Electrophysiological evidence from the rat

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