A Recombinant Fragment of Human Surfactant Protein D induces Apoptosis in Pancreatic Cancer Cell Lines via Fas-Mediated Pathway

Kaur, Anuvinder; Riaz, Muhammad; Murugaiah, Valarmathy; Varghese, Praveen M.; Singh, Shiv K.; Kishore, Uday

doi:10.3389/fimmu.2018.01126

Cited by 27 publications

(34 citation statements)

References 51 publications

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“…Translocation of NF-κB from the cytoplasm into the nucleus of pancreatic cancer cell lines was observed following treatment with SP-D. SP-D treatment caused upregulation of pro-apoptotic marker Fas, which then triggered cleavage of caspase 8 and 3. This study raises the possibility of using recombinant SP-D as a therapeutic molecule against pancreatic cancer irrespective of their p53 phenotype ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

“…The importance of SP-D in the regulation of the inflammation and homeostasis and in the protection against infection and allergens in the lung and at a range of extra-pulmonary mucosal sites is well documented ( 26 , 27 ). However, there are recent evidences to implicate SP-D as an immune surveillance molecule against cancer ( 19 , 20 ). In this study, we examined the potential prognostic value of this protein in lung, gastric, breast, and ovarian cancers.…”

Section: Discussionmentioning

confidence: 99%

“…It has recently been shown that SP-D also plays a role in the control of lung cancer progression via epidermal growth factor (EGF) signaling ( 19 ). Very recently, Kaur et al have shown that a recombinant fragment of human SP-D, composed of homotrimeric neck and C-type lectin domains, can induce apoptosis in pancreatic adenocarcinoma cell lines, such as Panc-1 (p53 mt ), MiaPaCa-2 (p53 mt ), and Capan-2 (p53 wt ), via Fas-mediated pathway ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

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Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer

et al. 2018

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Surfactant protein D (SP-D) is a pattern recognition molecule belonging to the Collectin (collagen-containing C-type lectin) family that has pulmonary as well as extra-pulmonary existence. In the lungs, it is a well-established opsonin that can agglutinate a range of microbes, and enhance their clearance via phagocytosis and super-oxidative burst. It can interfere with allergen–IgE interaction and suppress basophil and mast cell activation. However, it is now becoming evident that SP-D is likely to be an innate immune surveillance molecule against tumor development. SP-D has been shown to induce apoptosis in sensitized eosinophils derived from allergic patients and a leukemic cell line via p53 pathway. Recently, SP-D has been shown to suppress lung cancer progression via interference with the epidermal growth factor signaling. In addition, a truncated form of recombinant human SP-D has been reported to induce apoptosis in pancreatic adenocarcinoma via Fas-mediated pathway in a p53-independent manner. To further establish a correlation between SP-D presence/levels and normal and cancer tissues, we performed a bioinformatics analysis, using Oncomine dataset and the survival analysis platforms Kaplan–Meier plotter, to assess if SP-D can serve as a potential prognostic marker for human lung cancer, in addition to human gastric, breast, and ovarian cancers. We also analyzed immunohistochemically the presence of SP-D in normal and tumor human tissues. We conclude that (1) in the lung, gastric, and breast cancers, there is a lower expression of SP-D than normal tissues; (2) in ovarian cancer, there is a higher expression of SP-D than normal tissue; and (3) in lung cancer, the presence of SP-D could be associated with a favorable prognosis. On the contrary, at non-pulmonary sites such as gastric, breast, and ovarian cancers, the presence of SP-D could be associated with unfavorable prognosis. Correlation between the levels of SP-D and overall survival requires further investigation. Our analysis involves a large number of dataset; therefore, any trend observed is reliable. Despite apparent complexity within the results, it is evident that cancer tissues that produce less levels of SP-D compared to their normal tissue counterparts are probably less susceptible to SP-D-mediated immune surveillance mechanisms via infiltrating immune cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer

et al. 2018

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“…Umeda et al [15] reported that high serum SFTPD levels were associated with a lower number of distant metastases and better prognosis. Besides, recent studies also suggested that SFTPD could suppress the progression of pancreatic cancer by inducing epithelial-mesenchymal-transition (EMT) and apoptosis of pancreatic cancer cells [16,17]. Furthermore, SFTPA and SFTPB have been proposed to function as tumour suppressor genes as well, and their downregulation was closely related to poor prognosis of patients with lung cancer [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

“…Strikingly, it has been proposed that SFTPD expression was associated with tumour progression and survival of patients with lung cancer [13][14][15]. Furthermore, recent evidence also showed that SFTPD could suppress the progression of pancreatic cancer by inducing epithelial-mesenchymal-transition (EMT) and apoptosis of pancreatic cancer cells [16,17]. In addition, it has also been suggested that SFTPA and SFTPB might function as tumour suppressor genes and their dysregulation were closely related to poor prognosis of lung cancer patients [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

MiR-629-3p-induced downregulation of SFTPC promotes cell proliferation and predicts poor survival in lung adenocarcinoma

Meng

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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2019) MiR-629-3p-induced downregulation of SFTPC promotes cell proliferation and predicts poor survival in lung adenocarcinoma, Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 3286-3296, ABSTRACTThe long-term prognosis of patients with lung cancer remains poor and thus it is imminent to further elucidate the molecular mechanism for the oncogenesis of lung cancer. In this study, we observed that surfactant protein C (SFTPC) expression was downregulated in human lung adenocarcinoma tissues and cell lines, and low SFTPC expression correlated with poor overall survival of lung adenocarcinoma patients. Moreover, we found that overexpression of SFTPC could inhibit lung cancer cell proliferation in vitro and in vivo, but downregulation of SFTPC showed the opposite results. Besides, it was observed that miR-629-3p expression was upregulated in human lung adenocarcinoma tissues and cell lines. More importantly, we found that miR-629-3p could downregulate SFTPC expression by directly binding to the SFTPC 3'-UTR and inhibit the regulatory effect of SFTPC on lung adenocarcinoma cell proliferation. In conclusion, these data suggested that miR-629-3p-meditated downregulation of SFTPC may promote lung adenocarcinoma progression. ARTICLE HISTORY

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Surfactant Protein D in Immune Surveillance Against Cancer

Thakur

Mahajan

Kaur

et al. 2021

The Collectin Protein Family and Its Multiple Biological Activities

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A Recombinant Fragment of Human Surfactant Protein D induces Apoptosis in Pancreatic Cancer Cell Lines via Fas-Mediated Pathway

Cited by 27 publications

References 51 publications

Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer

Pathological Significance and Prognostic Value of Surfactant Protein D in Cancer

MiR-629-3p-induced downregulation of SFTPC promotes cell proliferation and predicts poor survival in lung adenocarcinoma

Surfactant Protein D in Immune Surveillance Against Cancer

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