“…The performance of such systems are not easily predictable, in particular when the design of the single pixel is not trivial and aims at introducing smart features like background rejection [ 10 , 11 , 12 , 13 , 14 ], interference suppression [ 15 ], or partial on-chip memory/histogramming [ 16 , 17 , 18 , 19 ]. Additionally, expensive solutions, like 3D stacking [ 8 , 9 , 20 ] and microlenses [ 21 ], are to be carefully evaluated before being employed. Consequently, it is desirable to tailor the design in order to meet the required specifications avoiding the risk to obtain either poor or overkilling performance.…”