A Reconfigurable and Portable Highly Sensitive Biosensor Platform for ISFET and Enzyme-Based Sensors

Lee, Ikho; Lee, SeungWoo; Lee, Ki-Young; Park, Chanoh; Kim, Dong-Hoon; Lee, Jeong-Soo; Yi, Hyunjung; Kim, Byungsub

doi:10.1109/jsen.2016.2541698

Cited by 13 publications

(8 citation statements)

References 15 publications

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“…ISFET output current may be measured by a readout circuit similar to that of an amperometric/impedimetric biosensor. However, it needs more controlled voltages (V RE and V DS ) and thus requires a different circuit [ 38 ]. The remainder of this paper will focus on biosensors with electrode transducers.…”

Section: Electrochemical Biosensor Techniquesmentioning

confidence: 99%

CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review

Liu²,

et al. 2016

Sensors

150

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Modern biosensors play a critical role in healthcare and have a quickly growing commercial market. Compared to traditional optical-based sensing, electrochemical biosensors are attractive due to superior performance in response time, cost, complexity and potential for miniaturization. To address the shortcomings of traditional benchtop electrochemical instruments, in recent years, many complementary metal oxide semiconductor (CMOS) instrumentation circuits have been reported for electrochemical biosensors. This paper provides a review and analysis of CMOS electrochemical instrumentation circuits. First, important concepts in electrochemical sensing are presented from an instrumentation point of view. Then, electrochemical instrumentation circuits are organized into functional classes, and reported CMOS circuits are reviewed and analyzed to illuminate design options and performance tradeoffs. Finally, recent trends and challenges toward on-CMOS sensor integration that could enable highly miniaturized electrochemical biosensor microsystems are discussed. The information in the paper can guide next generation electrochemical sensor design.

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Section: Electrochemical Biosensor Techniquesmentioning

confidence: 99%

CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review

Liu²,

et al. 2016

Sensors

150

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“…Due to its high sensitivity, rapid response, and compact size, the ISFET sensor is commonly used in biochemical analysis [18]. Additionally, the ISFET form factor is compact, energy-efficient, and affordable, rendering it highly suitable for onsite (field test) measurement [19][20][21][22]. However, the device suffers from inherent nonidealities (i.e., temperature drift), which considerably affect its performance due to the characteristic of the semiconductor substrate [23].…”

Section: Introductionmentioning

confidence: 99%

Portable Deep Learning-Driven Ion-Sensitive Field-Effect Transistor Scheme for Measurement of Carbaryl Pesticide

Houngkamhang

Phasukkit

2022

Sensors

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This research proposes a multiple-input deep learning-driven ion-sensitive field-effect transistor (ISFET) scheme to predict the concentrations of carbaryl pesticide. In the study, the carbaryl concentrations are varied between 1 × 10−7–1 × 10−3 M, and the temperatures of solutions between 20–35 °C. To validate the multiple-input deep learning regression model, the proposed ISFET scheme is deployed onsite (a field test) to measure pesticide concentrations in the carbaryl-spiked vegetable extract. The advantage of this research lies in the use of a deep learning algorithm with an ISFET sensor to effectively predict the pesticide concentrations, in addition to improving the prediction accuracy. The results demonstrate the very high predictive ability of the proposed ISFET scheme, given an MSE, MAE, and R2 of 0.007%, 0.016%, and 0.992, respectively. The proposed multiple-input deep learning regression model with signal compensation is applicable to a wide range of solution temperatures which is convenient for onsite measurement. Essentially, the proposed multiple-input deep learning regression model could be adopted as an effective alternative to the conventional statistics-based regression to predict pesticide concentrations.

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“…Flexible and wearable biosensors have been attracting rapidly increasing interest over the past several years owing to their great potential for monitoring health conditions by noninvasively analyzing chemicals in biofluids such as tears, sweat, and saliva. − Of the various biosensor systems, electrochemical enzymatic biosensors have received particularly extensive attention because their electrical measurement scheme is very simple and can be combined with electrical circuit technology , and wireless communication technology for continuous and noninvasive monitoring of biomarkers in biofluids. ,, In addition, redox enzymes possess many attractive attributes such as high efficiency of binding to their target molecules, long-term stability, high availability, and low cost. ,,− Enabling intimate electrical coupling among multiple functional components is of paramount importance for realizing high-performance electrochemical biosensors. − To enhance such electrical coupling, conductive nanoscale materials such as single-walled carbon nanotubes (SWNTs), , metal nanoparticles, ,− and nanowires that have dimensions similar to those of enzymes have been extensively employed. In addition to developing nanoscale electronic materials, various novel fabrication approaches combined with nanoscale electronic materials have also been developed to realize high-performance flexible biochemical sensors. ,− They include electrodeposition of a catalytic mediating layer made of an artificial peroxidase enzyme (i.e., Prussian blue) on nanostructured electrodes, ,− screen printing of inks that include such an artificial peroxidase enzyme and nanoscale electronic materials, ,,, and layer-by-layer (LBL) incorporation of enzymes on biologically assembled nanomesh electrodes. , However, fabrication of such enzyme electrodes has been carried out directly on the targeted electrodes and has thus required solution processing of enzymes directly on the devices and/or complica...…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydrodynamic Layer-by-Layer Assembly of Transferable Enzymatic Conductive Nanonetworks for Enzyme-Sticker-Based Contact Printing of Electrochemical Biosensors

Lee

Kang

Lee

et al. 2018

ACS Appl. Mater. Interfaces

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Realizing high-performance electrochemical biosensors in a simple contact-printing-based approach significantly increases the applicability of integrated flexible biosensors. Herein, an enzyme-sticker-based approach that enables flexible and multielectrochemical sensors via simple contact-transfer printing is reported. The enzyme sticker consists of an enzymatic conductive network film and a polymeric support. The enzyme-incorporated nanostructured conductive network showing an efficient electrical coupling was assembled via the hydrodynamic layer-by-layer assembly of redox enzymes, polyelectrolytes, single-walled carbon nanotubes, and a biological glue material, M13 phage. The enzymatic conductive network on a polymeric membrane support was facilely wet contact-transfer printed onto integrated electrode systems by exploiting varying degrees of hydrophilicity displayed by the enzymatic electronic film, polymeric support, and receiving electrodes of the sensor system. The glucose sensors fabricated using the enzyme sticker detected glucose at a concentration of as low as 35 μM and showed high selectivity and stability. Furthermore, a flexible dual-sensor array capable of detecting both glucose and lactate was demonstrated using the versatile enzyme sticker concept. This work presents a new route toward assembling and integrating hybrid nanomaterials with efficient electrochemical coupling for high-performance biosensors and health-monitoring devices as well as for emerging bioelectronics and electrochemical devices.

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A Reconfigurable and Portable Highly Sensitive Biosensor Platform for ISFET and Enzyme-Based Sensors

Cited by 13 publications

References 15 publications

CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review

CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review

Portable Deep Learning-Driven Ion-Sensitive Field-Effect Transistor Scheme for Measurement of Carbaryl Pesticide

Hydrodynamic Layer-by-Layer Assembly of Transferable Enzymatic Conductive Nanonetworks for Enzyme-Sticker-Based Contact Printing of Electrochemical Biosensors

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