A rectovaginal fistula after treatment with bevacizumab. A dangerous side effect needing emergency treatment

Galanopoulos, Michail; Ladias, Spyridon; Tzannetakou, Xanthippi; Tsigaridas, Athanasios; Sarafis, Alexandros; Liatsos, Christos; Kalafatis, Evangelos

doi:10.1002/ccr3.523

Cited by 10 publications

(5 citation statements)

References 4 publications

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“…К другим редким причинам свищей относятся облучение влагалища при лучевой терапии, вирусные и бактериальные инфекции у пациентов с вирусом иммунодефицита человека (ВИЧ) и сексуальное насилие [17][18][19]. Кроме то го, в литературе сообщалось о случаях спонтанного РВС, вторичного по отношению к бевацизумабу и акситинибу [20,21]. Также был зарегистрирован единичный случай редкого ятрогенного РВС, вызванного приемом резониума A [22].…”

Section: гинекологияunclassified

Modern opportunities for treatment of patients with rectovaginal fistulas: literature review

Myshentsev,

Katorkin,

Kuzmina

2023

Medicinskij sovet

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The review is devoted to the most pressing issues of etiology, classification, diagnosis and treatment of rectovaginal fistulas. The psychosocial impact of a rectovaginal fistula on women’s quality of life cannot be overemphasized. The most common causes of rectovaginal fistula are postoperative and obstetric complications, inflammatory bowel disease, complications of radiation therapy, and neoplasms. A combination of advanced imaging techniques, physical examination, and clinical experience can help determine the location and cause of a fistula. The therapeutic options are varied, but the results are often unsatisfactory. In this regard, the choice of a strategy for the treatment of rectovaginal fistulas should be based on etiology, localization and concomitant pathology. Despite the prevalence and serious consequences of rectovaginal fistulas, there is no generally accepted scientifically based approach to surgical treatment. Collaboration between obstetricians-gynecologists and colorectal surgeons, detailed preoperative assessment, consideration of optimal treatment options and correct surgical technique can achieve a successful outcome in most patients. The aim of the study is to evaluate, on the basis of literature sources, the problem of diagnosis and treatment of patients with rectovaginal fistulas and modern possibilities for improving the results of surgical interventions in this pathology. The methodological basis of the analysis was the study of domestic and foreign literature devoted to this problem. Scientific articles were selected for the period 2016–2021, with the largest randomized controlled trials in this area. The article provides an overview of the main management strategies and technical approaches that are currently effective in eliminating this socially disabling condition.

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Section: гинекологияunclassified

Modern opportunities for treatment of patients with rectovaginal fistulas: literature review

Myshentsev,

Katorkin,

Kuzmina

2023

Medicinskij sovet

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“…Bevacizumab, a humanized anti-VEGF monoclonal antibody, has been one of the most prevalent antiangiogenesis treatments, acting to normalize the vasculature and benefit the inhibitory effect of chemotherapeutic drugs, especially in malignant gliomas. 13 , 14 …”

Section: Interaction Of Vegf/vegfrs In Tumor Angiogenesismentioning

confidence: 99%

Targeting VEGF/VEGFRs Pathway in the Antiangiogenic Treatment of Human Cancers by Traditional Chinese Medicine

et al. 2018

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Bearing in mind the doctrine of tumor angiogenesis hypothesized by Folkman several decades ago, the fundamental strategy for alleviating numerous cancer indications may be the strengthening application of notable antiangiogenic therapies to inhibit metastasis-related tumor growth. Under physiological conditions, vascular sprouting is a relatively infrequent event unless when specifically stimulated by pathogenic factors that contribute to the accumulation of angiogenic activators such as the vascular endothelial growth factor (VEGF) family and basic fibroblast growth factor (bFGF). Since VEGFs have been identified as the principal cytokine to initiate angiogenesis in tumor growth, synthetic VEGF-targeting medicines containing bevacizumab and sorafenib have been extensively used, but prominent side effects have concomitantly emerged. Traditional Chinese medicines (TCM)–derived agents with distinctive safety profiles have shown their multitarget curative potential by impairing angiogenic stimulatory signaling pathways directly or eliciting synergistically therapeutic effects with anti-angiogenic drugs mainly targeting VEGF-dependent pathways. This review aims to summarize (a) the up-to-date understanding of the role of VEGF/VEGFR in correlation with proangiogenic mechanisms in various tissues and cells; (b) the elaboration of antitumor angiogenesis mechanisms of 4 representative TCMs, including Salvia miltiorrhiza, Curcuma longa, ginsenosides, and Scutellaria baicalensis; and (c) circumstantial clarification of TCM-driven therapeutic actions of suppressing tumor angiogenesis by targeting VEGF/VEGFRs pathway in recent years, based on network pharmacology.

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“…Bevacizumab treatment is associated with several side effects, such as hypertension, proteinuria, impaired wound healing, and intestinal perforations . There are several reports in the literature about rectovaginal fistula during bevacizumab treatment, where rectovaginal fistula was diagnosed by CT scan or colonoscopy. There are no reports about sigmoid‐vaginal fistula during bevacizumab treatment.…”

Section: What Is Known and Objectivesmentioning

confidence: 99%

Sigmoid-vaginal fistula during bevacizumab treatment diagnosed by fistulography

et al. 2016

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A rectovaginal fistula after treatment with bevacizumab. A dangerous side effect needing emergency treatment

Cited by 10 publications

References 4 publications

Modern opportunities for treatment of patients with rectovaginal fistulas: literature review

Modern opportunities for treatment of patients with rectovaginal fistulas: literature review

Targeting VEGF/VEGFRs Pathway in the Antiangiogenic Treatment of Human Cancers by Traditional Chinese Medicine

Sigmoid-vaginal fistula during bevacizumab treatment diagnosed by fistulography

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